Polydopamine modified Au/FAU catalytic membrane for CO preferential oxidation

A hollow-fiber-supported stable Au/FAU catalytic membrane was successfully synthesized through a polydopamine coating modification-removal strategy and used as a flow-through catalytic membrane reactor for preferential oxidation of CO.Small Au nanoparticles can be efficiently isolated by dopamine and the dopamine-derived carbon shells.The interactions between Au nanoparticles and zeolite layer support are enhanced during annealing at high temperature under an inert atmosphere.A zeolite membrane supported Au nanoparticle catalyst was obtained after the removal of carbon shells,which showed high catalytic activity and stability for the removal of CO from hydrogen.

A Transparent Ultrasound Array for Real-Time Optical,Ultrasound,and Photoacoustic Imaging

Objective and Impact Statement.Simultaneous imaging of ultrasound and optical contrasts can help map structural,functional,and molecular biomarkers inside living subjects with high spatial resolution.There is a need to develop a platform to facilitate this multimodal imaging capability to improve diagnostic sensitivity and specificity.Introduction.Currently,combining ultrasound,photoacoustic,and optical imaging modalities is challenging because conventional ultrasound transducer arrays are optically opaque.As a result,complex geometries are used to coalign both optical and ultrasound waves in the same field of view.Methods.One elegant solution is to make the ultrasound transducer transparent to light.Here,we demonstrate a novel transparent ultrasound transducer(TUT)linear array fabricated using a transparent lithium niobate piezoelectric material for real-time multimodal imaging.Results.The TUT-array consists of 64 elements and centered at~6 MHz frequency.We demonstrate a quad-mode ultrasound,Doppler ultrasound,photoacoustic,and fluorescence imaging in real-time using the TUT-array directly coupled to the tissue mimicking phantoms.Conclusion.The TUT-array successfully showed a multimodal imaging capability and has potential applications in diagnosing cancer,neurological,and vascular diseases,including image-guided endoscopy and wearable imaging.

An integrated flexible self-healing Zn-ion battery using dendrite-suppressible hydrogel electrolyte and free-standing electrodes for wearable electronics

Among many aqueous batteries,flexible zinc-ion(Zn-ion)battery becomes the focus owing to the merits of low cost,non-toxicity,and safety.Here,a Zn dendrite-suppressible hydrogel electrolyte with both flexible and self-healing properties is developed via photoinitiated polymerization.The cross-linked structure of the polyacrylamide-N,N'-methylenebisacrylamide(PAM-MBA)-Zn/Mn hydrogel endows an enlarged chemical stable window,high ionic conductivity,and low polarization potential.After cycling at the current density of 0.5 mA·cm^(−2)for 250 h,Zn‖Zn symmetrical cell based on PAM-MBA-Zn/Mn electrolyte delivers a low polarization of 40 mV.The suppressed dendrite growth is ascribed to the uniform Zn deposition/stripping on anode.The galvanostatic intermittent titration technique curves display that the Zn-ion battery constructed by the PAM-MBA-Zn/Mn hydrogel electrolyte,free-standing FeVO_(4)/carbon cloth cathode,and Zn nanosheets/carbon cloth anode presents low reaction resistance and fast diffusion coefficient,indicating good endurance of cycling at high current densities.The battery with PAM-MBA-Zn/Mn hydrogel electrolyte presents a good flexible and self-healing performance.After bending 0°,60°,90°,and 180°for 30 times,batteries deliver stable capacities.Even cutting into ten pieces,the battery could self-heal and display a potential retention of 93.7%compared to the fresh cell.A good rate-performance is also achieved.After cutting/healing three times during cycling,capacity recovers well compared to the first-time cutting/healing.Moreover,the battery exhibits good flexibility using in an electric watch,indicating a promising potential for wearable electronics.

Malignant transformation by oncogenic K-ras requires IDH2-mediated reductive carboxylation to promote glutamine utilization

Dear Editor,Oncogenic K-ras mutation plays a major role in malignant transformation and induces significant alterations in cancer cell metabolism[1–4].However,the major molecular players mediating metabolic alterations during K-ras-driven cancer development remain elusive.The observations that tumorigenesis often requires multiple hits suggest that K-ras mutation likely needs the coordination of other molecular events that enable adaptive cellular metabolism for a full malignant transformation.Based on our previous study on the impact of K-ras onmitochondrial metabolism[1,5]and our recent findings that mitochondrial isocitrate dehydrogenase 2(IDH2)could promote the“reverse”flow of the tricarboxylic acid(TCA)cycle fromα-KG to isocitrate and enhance the survival and proliferation of acute myeloid leukemia cells[6],we investigated the potential role of IDH2 in metabolic adaptation during K-ras-driven tumorigenesis.

Ultra-conformable liquid metal particle monolayer on air/water interface for substrate-free E-tattoo

Gallium-based liquid metal has gained significant attention in conformal flexible electronics due to its high electrical conductivity,intrinsic deformability,and biocompatibility.However,the fabrication of large-area and highly uniform conformal liquid metal films remains challenging.Interfacial self-assembly has emerged as a promising method,but traditional approaches face difficulties in assembling liquid metal particles.Here,we realized the multi-size universal self-assembly(MUS)for liquid metal particles with various diameters(<500μm).By implementing a z-axis undisturbed interfacial material releasing strategy,the interference of gravitational energy on the stability of floating particles is avoided,enabling the fabrication of ultra-conformable monolayer films with large areas(>100 cm^(2))and high floating yield(50–90%).Moreover,the films can be conformally transferred onto complex surfaces such as human skin,allowing for the fabrication of substrate-free flexible devices.This eliminates interference from traditional substrate mechanical responses,making the liquid metal e-tattoo more user-friendly.

Preparation of hollow fiber membranes from mullite particles with aid of sintering additives

Porous mullite hollow fiber membranes were prepared with a combined phase-inversion and sintering method,using three sintering additives including yttrium stabilized zirconia(YSZ),small mullite particles(SMP),and titanium oxide(TiO2)to promote the particle sintering.The results indicated that all the three additives could improve the sintering performance of mullite hollow fiber membranes due to the decrease in activation energy of mullite grains.Both YSZ and T i02 could react with mullite grains to generate composite oxides(e.g.,ZrSi04 and Al2Ti05)during sintering,following a reaction-sintering mechanism.Interestingly,the newly generated ZrSiO4 was instable and further decomposed into monoclinic ZrO2 and SiO2 in the sintering process.The decomposition could avoid excessive embedment of composite oxides among mullite grains which have negative impact on mechanical strength of mullite hollow fibers.Overall,the doping of YSZ provided a better promotion effect on the sintering of mullite hollow fiber membranes,where the microstructural and mechanical properties are insensitive to the doping content and sintering temperatures,so it could be used as the candidate for the large-scale preparation of mullite hollow fibers.

Predicting adsorption ability of adsorbents at arbitrary sites for pollutants using deep transfer learning

Accurately evaluating the adsorption ability of adsorbents for heavy metal ions(HMIs)and organic pollutants in water is critical for the design and preparation of emerging highly efficient adsorbents.However,predicting adsorption capabilities of adsorbents at arbitrary sites is challenging,with currently unavailable measuring technology for active sites and the corresponding activities.Here,we present an efficient artificial intelligence(AI)approach to predict the adsorption ability of adsorbents at arbitrary sites,as a case study of three HMIs(Pb(Ⅱ),Hg(Ⅱ),and Cd(Ⅱ))adsorbed on the surface of a representative two-dimensional graphitic-C_(3)N_(4).We apply the deep neural network and transfer learning to predict the adsorption capabilities of three HMIs at arbitrary sites,with the predicted results of Cd(Ⅱ)>Hg(Ⅱ)>Pb(Ⅱ)and the root-mean-squared errors less than 0.1 eV.The proposed AI method has the same prediction accuracy as the ab initio DFT calculation,but is millions of times faster than the DFT to predict adsorption abilities at arbitrary sites and only requires one-tenth of datasets compared to training from scratch.We further verify the adsorption capacity of g-C_(3)N_(4) towards HMIs experimentally and obtain results consistent with the AI prediction.It indicates that the presented approach is capable of evaluating the adsorption ability of adsorbents efficiently,and can be further extended to other interdisciplines and industries for the adsorption of harmful elements in aqueous solution.

钆塞酸二钠增强磁共振成像肝胆期对比剂摄取相关参数评估药物性肝损伤的价值

目的探讨钆塞酸二钠(Gd-EOB-DTPA)增强磁共振成像(MRI)肝胆期对比剂摄取相关参数评估药物性肝损伤(DILI)患者肝损伤程度的价值。方法选择2020年1月至2021年6月扬州大学附属苏北人民医院收治的55例DILI患者,其中轻症DILI组29例,重症DILI组26例。选择同期30例肝功能正常患者(非DILI组)作为对照。回顾性分析患者Gd-EOB-DTPA增强MRI图像,测量增强前及增强后肝胆期肝脏、门静脉与脾脏信号强度,计算肝脏相对强化程度(RE)、肝脏相对于门静脉强化程度比(LPC)、肝脏相对于脾脏强化程度比(LSC),同时评价功能性肝脏影像评分(FLIS)。比较非DILI组、轻症DILI组、重症DILI组患者各参数差异。采用Pearson相关分析Gd-EOB-DTPA增强MRI肝胆期对比剂摄取相关参数与肝功能指标的相关性。绘制受试者操作特征(ROC)曲线分析Gd-EOB-DTPA增强MRI肝胆期对比剂摄取相关参数鉴别轻症DILI组与重症DILI组的效能。结果DILI组患者RE、LPC、LSC均低于非DILI组患者,且随着肝损伤程度的加重而降低,且差异均有统计学意义(P均<0.05)。RE、LPC与DILI患者总胆红素水平呈中度负相关(r=-0.53、-0.51,P<0.05),与DILI患者总蛋白水平呈中度正相关(r=0.54、0.53,P<0.05)。ROC曲线显示,RE、LPC、LSC、FLIS区分轻症DILI组与重症DILI组患者的曲线下面积(AUC)分别为0.74、0.81、0.74、0.78。结论Gd-EOB-DTPA增强MRI肝胆期对比剂摄取相关参数可评估DILI患者肝损伤程度,为临床定量评估DILI严重程度提供了新的辅助方法。