Aurone derivatives were synthesized in good to high yields by PBu_(3)-catalyzed intramolecular 5-exo cyclization of 2-alkynoylphenols.The reaction proceeds in high regioselectivity without forming 6-endo cyclization p...Aurone derivatives were synthesized in good to high yields by PBu_(3)-catalyzed intramolecular 5-exo cyclization of 2-alkynoylphenols.The reaction proceeds in high regioselectivity without forming 6-endo cyclization products.展开更多
A silver-catalyzed,K_(2)S_(2)O_(8)-mediated protocol to access regioselective acylarylation of unactivated alkenes was developed.The reaction between N-allyl-indoles andα-oxocarboxylic acids proceeded smoothly and in...A silver-catalyzed,K_(2)S_(2)O_(8)-mediated protocol to access regioselective acylarylation of unactivated alkenes was developed.The reaction between N-allyl-indoles andα-oxocarboxylic acids proceeded smoothly and involved an acyl radical addition/C–H cyclization cascade.The protocol showed a broad substrate scope and good tolerance of functional groups.The reaction proceeded with both internal and terminal alkenes to furnish many functional pyrrolo[1,2-a]indoles bearing the ketone carbonyl group,and this feature also provides the potential to construct structurally complex N-containing heterocycles.展开更多
基金The authors are grateful to the financial support from the National Natural Science Foundation of China(No.21272004).
文摘Aurone derivatives were synthesized in good to high yields by PBu_(3)-catalyzed intramolecular 5-exo cyclization of 2-alkynoylphenols.The reaction proceeds in high regioselectivity without forming 6-endo cyclization products.
基金the National Natural Science Foundation of China(21702237,21272004)the Natural Science Research Project for Anhui Universities,the Start-up Research Fund of Anhui Normal University and the Project for Students’Innovative Experiment of Anhui Normal University for their financial support.
文摘A silver-catalyzed,K_(2)S_(2)O_(8)-mediated protocol to access regioselective acylarylation of unactivated alkenes was developed.The reaction between N-allyl-indoles andα-oxocarboxylic acids proceeded smoothly and involved an acyl radical addition/C–H cyclization cascade.The protocol showed a broad substrate scope and good tolerance of functional groups.The reaction proceeded with both internal and terminal alkenes to furnish many functional pyrrolo[1,2-a]indoles bearing the ketone carbonyl group,and this feature also provides the potential to construct structurally complex N-containing heterocycles.
