Armarium facilitating angina management post myocardial infarction concomitant with coronavirus disease 2019

The outbreak and spread of coronavirus disease 2019(COVID-19)are not only a disaster of people’s life and health over the world,[1–3]but also the challenge for medical practitioner in clinical management.Owing to many diagnostic instruments are not suitable or convenient to use any more in contagious ward considering the risk of cross infections,such as traditional stethoscope or electrocardiogram(ECG).In this scenarios,wireless and digital equipment are optimal choices for epidemic management in order to exert rapid diagnosis and disease evaluation.Herein,we reported a case of the patient suffering both COVID-19 and myocardial infarction,for which the tele-ECG and wireless stethoscope facilitated the accurate diagnosis and instant management.

Novel coronavirus"Omicron subtype variant strain BA.2":The latest research progress

Since the outbreak of COVID-19,with the emergence of a series of novel coronavirus variants of different types,COVID-19 has continued to spread across the globe,posing a huge threat to the lives and health of people around the world and posing a severe challenge to global public health security.Recently,the World Health Organization(WHO)announced that novel coronavirus variant strain"Omicron"subtype variant strain BA.2 has been found in 57 countries and regions.It has higher vaccine and antibody tolerance and is more infectious than omicron(B.1.1.529).In this paper,we briefly review the recent studies on the omicron subtype variant strain BA.2.

Recent research progress on subtypes of Omicron

Since the outbreak of Novel coronavirus pneumonia(COVID-19),Novel coronavirus has undergone evolution and variation in the process of transmission,and has formed many variant strains.There are five variants of concern,Alpha,Beta,Gamma,Delta and Omicron.In November 9,2021,South Africa firstly detected a variant strain(B.1.1.529)from a sample of cases.In November 26,the World Health Organization named it"Omicron variant strain",Currently,the Omicron variant strain has become the main epidemic variant strain in the world.Omicron variant strain consists of several subtypes,including BA.1,BA.2 and BA.3.The subtypes of Omicron variant strain have different mutation and infectivity.This article reviews the characteristics and immune escape mechanisms of each Omicron variant strain subtype.

New progress of novel COVID-19 variants and its effect on vaccine immune protection

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)poses a serious threat to human life and health as well as social and economic development.In order to deal with this public health event,scientific research institutions around the world have rapidly developed and put vaccines into urgent use,bringing hope to the victory over the epidemic.However,as the Novel Coronavirus continues to spread throughout the world,the virus genome has mutated to form a variety of variants.Among them,the Alpha,Beta,Gamma,Delta and Omicron variants show higher infectivity and higher resistance to vaccines and neutralizing antibodies,posing new challenges to the prevention and treatment of COVID-19.At present,the effect of variants on the effectiveness of developed vaccines has become a hot topic of global discussion.In this paper,we briefly review the new progress of novel Coronavirus variants and their effects on vaccine immune protection.

COVID-19 sequelae:Clinical features and research progress

With the increasing number of COVID-19 patients cured and discharged,the emergence of associated sequelae has become a new global health crisis following acute infection.The sequela of COVID-19 involves many systems such as respiration,circulation,nerve,digestion,psychological cognition,and so on,with varying duration and severity,seriously affecting people's physical and mental health,as well as the development of society.This paper summarizes the clinical characteristics and research progress of COVID-19 sequelae through extensive review of relevant domestic and foreign literature,in order to provide reference for the development of a comprehensive and systematic management system.

The latest research progress of the Corona Virus Disease 2019 mutant strain"Omicron"

Coronavirus disease 2019(COVID-19)that broke out at the end of December 2019 has been raging for 3 years,bringing unpredictable harm to the physical and mental health of all mankind and global economic development.The new type of coronavirus pneumonia is a new type of respiratory infectious disease with a high incidence and fatality rate caused by SARS-CoV-2.Up to now,hundreds of millions of people have been infected with new coronary pneumonia worldwide,and millions of people have died.Due to the specificity of the new coronavirus itself and its high mutation rate,a series of different new coronavirus variants have appeared,which has caused the new crown pneumonia epidemic to repeat.Recently,the World Health Organization(WHO)announced a new variant"omicron"(omicron,B.1.1.529),and declared that the mutant strain may be highly infectious,antibody tolerant and highly resistant to vaccines.This article briefly reviews the latest research progress of the"omicron"variants.

Virological Characteristics and Prevention and Control of Omicron Sub-lineage BA.2

The Omicron sub-lineage BA.2 has caused a new round of infection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),leading to a surge in the number of COVID-19 cases in many countries,including China.Because the subvariant BA.2 shows strong infectivity,fast transmission,strong immune escape ability,relatively mild symptoms,strong concealment,difficult to find and so on,it has gradually become a new challenge during the COVID-19 pandemic.Understanding the virological characteristics of Omicron sub-lineage BA.2 is of great significance for epidemic prevention and control.This paper briefly summarizes the virological characteristics and prevention and control strategies of Omicron sub-lineage BA.2.

Research progress on the effect of COVID-19 on gastrointestinal tract

The outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)in 2019 threatens global public health.In the early stage,respiratory symptoms are the most common in patients with new coronal pneumonia,but with the spread of the disease around the world,gastrointestinal symptoms such as diarrhea,nausea and vomiting have attracted more and more attention.And some patients take diarrhea as the first symptom,which is easy to cause missed diagnosis.This paper expounds the close relationship between COVID-19 and gastrointestinal tract,and reviews the research progress of COVID-19's effect on gastrointestinal tract.

The latest research progress of COVID-19 mutant strain "Mu" virus strain

Novel coronavirus pneumonia(COVID-19)is a highly pathogenic infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Until now,the new crown pneumonia has caused hundreds of millions of people worldwide to be infected.Novel coronavirus pneumonia is still a high level of variation.Due to the high variability of COVID-19,there are already a large number of COVID-19 variant strains that are still at a high level of infection worldwide.Recently,WHO(WHO)released a new variant,"Mu"(μ,B.1.621)may be a high vaccine tolerance.This paper reviews the latest research progress of"Mu"virus strain in detail.

Research progress on detection methods of the asymptomatic COVID- 19 infected persons

The global pandemic of COVID-19 has brought great harm and challenges to many countries and regions around the world.The majority of COVID-19 patients have typical clinical manifestations,but the number of asymptomatic infections is increasing as COVID-19 research continues and SARS-CoV-2 testing improves.Many asymptomatic COVID-19 patients with no obvious clinical symptoms are able to transmit the virus to others due to the presence of SARS-CoV-2 in their bodies,thus greatly accelerating the worldwide pandemic and posing great difficulty and threat to global epidemic prevention and control.Therefore,early detection and identification of asymptomatic infected persons through various testing methods are effective measures to control the COVID-19 pandemic.This article will provide a brief review of the available methods and techniques for detecting asymptomatic COVID-19 patients.

The latest research progress in asymptomatic and pre-symptomatic patients with COVID-19

The asymptomatic and pre-symptomatic infections of coronavirus disease 2019(COVID-19)has no perceptible clinical symptoms and signs,and it is not easy to be detected. The transmission of the virus carried by asymptomatic and pre-symptomatic patients is insidious,which brings great challenges to the control of the epidemic. Due to the length of the incubation period,some studies have failed to distinguish between asymptomatic and pre-symptomatic infections,resulting in a higher proportion of asymptomatic infections. This article reviews the latest research progress of characteristics,transmission,detection and control of asymptomatic and pre-symptomatic infection.

Research progress on COVID-19 combined with digestive system diseases

The corona virus disease 2019(COVID-19)is an acute respiratory infection caused by the binding of SEVERE acute respiratory syndrome coronavirus 2(SARS-COV-2)and the angiotensin-converting enzyme 2(ACE2)receptor to the host target organ.New research suggests that COVID-19 may be a systemic infectious disease and a systemic inflammatory disease.Symptoms and signs of the digestive system are often found in patients with coVID-19 following acute infection.At present,despite the existence of some coronavirus-related digestive diseases(such as gastrointestinal diseases,liver injury,pancreatic injury,etc.),the pathogenesis of COVID-19 with digestive symptoms in existing studies is still unclear,and relevant guidelines and expert consensus are not enough for clinical diagnosis and treatment.Therefore,it is extremely important to understand the clinical manifestations,pathogenesis and prognosis of coVID-19 patients with digestive system.

Research progress on the correlation between immunosuppressive population and SARS-CoV-2 variation

Recently,some severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants represented by B.1.7(Alpha),B.1.351(Beta),P1(Gamma),B.1.617(Delta)and B.1.529(Omicron)have higher transmission and pathogenicity.Especially,Omicron causes global panic because of its high mutation in infectivity and vaccine escape,and their emergence makes the epidemic more difficult to control.The latest research reports indicate that these new corona mutants may first be mutated in the special population of immunosuppressive patients,and long-term infection and artificial immunotherapy may promote the variation of SARS-CoV-2.Not only that,there are a large number of congenital or acquired immunosuppressive patients worldwide,and immunosuppressive patients infected with SARS-CoV-2 will also have different impacts on social public health security.Therefore,we should pay more attention to the immunosuppressive population.This paper will briefly analyze the correlation between immunosuppressive population and SARS-CoV-2 variation in the form of review.