To the Editor： Vitiligo is not a fatal disease; however, it can have strong social and psychological impacts on the patients. Genetic susceptibility, autoimmunity, neural dysregulation, melanin self-destruction, and ...To the Editor： Vitiligo is not a fatal disease; however, it can have strong social and psychological impacts on the patients. Genetic susceptibility, autoimmunity, neural dysregulation, melanin self-destruction, and oxidative stress may be involved in the pathogenesis of vitiligo.展开更多
To the Editor:Metastatic melanoma is a fatal disease with rapid systemic dissemination and a 5-year survival rate of about 1 7%.[1] More than half of primary metastases involve the skin as nodal,subcutaneous,or distan...To the Editor:Metastatic melanoma is a fatal disease with rapid systemic dissemination and a 5-year survival rate of about 1 7%.[1] More than half of primary metastases involve the skin as nodal,subcutaneous,or distant metastasis.[2] Cutaneous metastases of melanoma occur relatively frequently and can arise in early-or late-stage disease,with a variable clinical appearance and pattern distribution.[3] We describe herein a patient with a large subcutaneous nodule on the arm that we initially diagnosed as a lipoma.After obtaining further clinical history and reviewing the pathologic findings after excision,the nodule was determined to represent metastatic melanoma.展开更多
To the Editor:A 1-year-old boy presented to our department with progressive linear scalp hair loss that had been present for 1 month.Physical examination revealed an annular alopecic patch of approximately 1.5 cm in w...To the Editor:A 1-year-old boy presented to our department with progressive linear scalp hair loss that had been present for 1 month.Physical examination revealed an annular alopecic patch of approximately 1.5 cm in width located on right parietal and occipital areas of the scalp[Figure 1A].The lesion was smooth with no erythema or scales.The patient experienced no other discomfort.His medical history and family history were unremarkable.Laboratory investigations including a complete blood count,urinalysis,liver and renal function,immunoglobulin(Ig),erythrocyte sedimentation rate,anti-double-stranded DNA,anti-Sm,anti-Ro/SSA,and anti-La/SSB antibody determinations were all normal or negative.The C3 component was 0.61 g/L(0.79-1.52 g/L)and the antinuclear antibody was positive(1:80).展开更多
IntroductionSyphilis is a sexually transmitted disease that is common worldwide.Because of its complicated and variant clinical manifestations,it can be challenging to diagnose.Here,we report a case of annular syphili...IntroductionSyphilis is a sexually transmitted disease that is common worldwide.Because of its complicated and variant clinical manifestations,it can be challenging to diagnose.Here,we report a case of annular syphilis,which is an uncommon form of secondary syphilis,on a rare region.This interesting case provides clinicians with knowledge that may aid them in making correct and differential diagnoses.Our work also emphasizes upon the need to pay more attention to uncommon clinical presentations of syphilis.展开更多
To the Edteor:Squamous cell carcinoma(SCC)in the ungual apparatus is a rare neoplasm.Although it is the most prevalent malignant tumor in this region,it often presents with non-specific features that lead to misdiagno...To the Edteor:Squamous cell carcinoma(SCC)in the ungual apparatus is a rare neoplasm.Although it is the most prevalent malignant tumor in this region,it often presents with non-specific features that lead to misdiagnosis and delayed treatment.[1]Various treatments have been proposed,including Mohs micrographic surgery,wide local excision with skin grafting,and amputation of the digit.Given the rarity of the condition,there is no consensus on the optimal treatment.[2]Photodynamic therapy(PDT)has been extensively used to treat nonmelanoma skin cancers,such as actinic keratosis,basal cell carcinoma,and SCC in situ.[3]The difficult treatment of subungual SCC and the success rates of PDT for early SCC suggested that this treatment would be useful for treating the following patient,who was diagnosed with subungual SCC but refused surgery and was ultimately successfully treated with topical PDT.展开更多
文摘To the Editor： Vitiligo is not a fatal disease; however, it can have strong social and psychological impacts on the patients. Genetic susceptibility, autoimmunity, neural dysregulation, melanin self-destruction, and oxidative stress may be involved in the pathogenesis of vitiligo.
文摘To the Editor:Metastatic melanoma is a fatal disease with rapid systemic dissemination and a 5-year survival rate of about 1 7%.[1] More than half of primary metastases involve the skin as nodal,subcutaneous,or distant metastasis.[2] Cutaneous metastases of melanoma occur relatively frequently and can arise in early-or late-stage disease,with a variable clinical appearance and pattern distribution.[3] We describe herein a patient with a large subcutaneous nodule on the arm that we initially diagnosed as a lipoma.After obtaining further clinical history and reviewing the pathologic findings after excision,the nodule was determined to represent metastatic melanoma.
基金supported by a grant from the National Natural Science Foundation of China(No.81903228)。
文摘To the Editor:A 1-year-old boy presented to our department with progressive linear scalp hair loss that had been present for 1 month.Physical examination revealed an annular alopecic patch of approximately 1.5 cm in width located on right parietal and occipital areas of the scalp[Figure 1A].The lesion was smooth with no erythema or scales.The patient experienced no other discomfort.His medical history and family history were unremarkable.Laboratory investigations including a complete blood count,urinalysis,liver and renal function,immunoglobulin(Ig),erythrocyte sedimentation rate,anti-double-stranded DNA,anti-Sm,anti-Ro/SSA,and anti-La/SSB antibody determinations were all normal or negative.The C3 component was 0.61 g/L(0.79-1.52 g/L)and the antinuclear antibody was positive(1:80).
文摘IntroductionSyphilis is a sexually transmitted disease that is common worldwide.Because of its complicated and variant clinical manifestations,it can be challenging to diagnose.Here,we report a case of annular syphilis,which is an uncommon form of secondary syphilis,on a rare region.This interesting case provides clinicians with knowledge that may aid them in making correct and differential diagnoses.Our work also emphasizes upon the need to pay more attention to uncommon clinical presentations of syphilis.
基金supported by a grant of the National Natural Science Foundation of China(No.81903198).
文摘To the Edteor:Squamous cell carcinoma(SCC)in the ungual apparatus is a rare neoplasm.Although it is the most prevalent malignant tumor in this region,it often presents with non-specific features that lead to misdiagnosis and delayed treatment.[1]Various treatments have been proposed,including Mohs micrographic surgery,wide local excision with skin grafting,and amputation of the digit.Given the rarity of the condition,there is no consensus on the optimal treatment.[2]Photodynamic therapy(PDT)has been extensively used to treat nonmelanoma skin cancers,such as actinic keratosis,basal cell carcinoma,and SCC in situ.[3]The difficult treatment of subungual SCC and the success rates of PDT for early SCC suggested that this treatment would be useful for treating the following patient,who was diagnosed with subungual SCC but refused surgery and was ultimately successfully treated with topical PDT.
