Gastric cancer(GC)is one of the most common causes of cancer-related death worldwide,and gastric cancer stem cells(GCSCs)are considered as the major factor for resistance to conventional radio-and chemotherapy.Accumul...Gastric cancer(GC)is one of the most common causes of cancer-related death worldwide,and gastric cancer stem cells(GCSCs)are considered as the major factor for resistance to conventional radio-and chemotherapy.Accumulating evidence in recent years implies that GCSCs regulate the drug resistance in GC through multiple mechanisms,including dormancy,drug trafficking,drug metabolism and targeting,apoptosis,DNA damage,epithelial-mesenchymal transition,and tumor microenvironment.In this review,we summarize current advancements regarding the relationship between GCSCs and drug resistance and evaluate the molecular bases of GCSCs in drug resistance.展开更多
基金supported by grants from the National Natural Science Foundation of China(No.82173003)the National Key R&D Program of China(No.2017YFA0503900)+4 种基金the Science and Technology Program of Guangdong Province in China(No.2019B030301009)the Industry and Information Technology Foundation of Shenzhen(No.20180309100135860)the SZU Top Ranking Project(No.86000000210)the Guangdong Basic and Applied Basic Research Foundation(No.2020A1515010989)the Medical Scientific Research Foundation of Guangdong Province(A2019434)。
文摘Gastric cancer(GC)is one of the most common causes of cancer-related death worldwide,and gastric cancer stem cells(GCSCs)are considered as the major factor for resistance to conventional radio-and chemotherapy.Accumulating evidence in recent years implies that GCSCs regulate the drug resistance in GC through multiple mechanisms,including dormancy,drug trafficking,drug metabolism and targeting,apoptosis,DNA damage,epithelial-mesenchymal transition,and tumor microenvironment.In this review,we summarize current advancements regarding the relationship between GCSCs and drug resistance and evaluate the molecular bases of GCSCs in drug resistance.
