It is of significance to construct continuous multiphase percolation channels with fast lithium-ion pathway in hybrid solid electrolytes.3D ceramic nanostructure frameworks have attracted great attention in this field...It is of significance to construct continuous multiphase percolation channels with fast lithium-ion pathway in hybrid solid electrolytes.3D ceramic nanostructure frameworks have attracted great attention in this field.Herein,the three-dimensional perovskite Li_(0.33)La_(0.557)TiO_(3)nanotubes framework(3D-LLTO-NT)is fabricated via a facile coaxial electro-spinning process followed by a calcination process at 800°C.The hybrid polymer electrolyte of 3DLLTO-NT framework and poly(ethylene carbonate)(3D-LLTO-NT@PEC)shows improved ionic conductivity of 1.73×10^(-4)S cm^(-1)at ambient temperature,higher lithium-ion transference number(t_(Li)^(+))of 0.78 and electrochemical stability window up to 5.0 V vs Li/Li^(+).The all-solid-state cell of LiFePO_(4)/3D-LLTO-NT@PEC/Li delivers a high specific capacity of 140.2 mAh g^(-1)at 0.1 C at ambient temperature.This outstanding performance is attributed to the 3D ceramic nanotubes frameworks which provide fast lithium ion transfer pathway and stable interfaces.展开更多
Ocular drug delivery remains a significant challenge that is limited by poor corneal retention and permeation,resulting in low ocular bioavailability(<5%).Worse still,the most convenient and safe route of ocular dr...Ocular drug delivery remains a significant challenge that is limited by poor corneal retention and permeation,resulting in low ocular bioavailability(<5%).Worse still,the most convenient and safe route of ocular drug administration,topical administration results in a drug bioavailability of less than 1%.iRGD modified drug delivery strategies have been developed for cancer therapy,however active targeting iRGD platforms for ocular drug delivery have yet to be explored.Herein,an iRGD modified liposomes was developed for ocular drug delivery via topical administration.The results indicated that iRGD modified liposomes could prolong the corneal retention time and enhance corneal permeability in an iRGD receptor mediated manner.These findings provided a novel strategy for topical ocular drug delivery for the treatment of posterior ocular diseases.展开更多
It was found for the first time that Cs_(2)CO_(3) serves as highly efficient catalyst for the direct hydroxylation reactions of phosphonates under mild conditions.This reaction provides an efficient approach to quater...It was found for the first time that Cs_(2)CO_(3) serves as highly efficient catalyst for the direct hydroxylation reactions of phosphonates under mild conditions.This reaction provides an efficient approach to quaternaryα-hydroxy phosphonates,which possess intriguing biological activities and are widely used in many areas.展开更多
A novel palladium/copper-catalyzed aerobic synthesis of bisaryl ketones from 1,2-diarylalkenes via C-C double bonds cleavage has been described.This reaction constitutes a new transformation from 1,2-diarylalkenes int...A novel palladium/copper-catalyzed aerobic synthesis of bisaryl ketones from 1,2-diarylalkenes via C-C double bonds cleavage has been described.This reaction constitutes a new transformation from 1,2-diarylalkenes into bisaryl ketones,providing a unifying,simple and environmentally friendly complement to the available methods.展开更多
基金financial support from Key Scientific and Technological Project of Wuhan City(Grant no.2018010401011279)Team Innovation Foundation of Hubei province(Grant no.T201935)National Natural Science Foundation of China(Grant nos.51872127,22209059 and 22139001)
文摘It is of significance to construct continuous multiphase percolation channels with fast lithium-ion pathway in hybrid solid electrolytes.3D ceramic nanostructure frameworks have attracted great attention in this field.Herein,the three-dimensional perovskite Li_(0.33)La_(0.557)TiO_(3)nanotubes framework(3D-LLTO-NT)is fabricated via a facile coaxial electro-spinning process followed by a calcination process at 800°C.The hybrid polymer electrolyte of 3DLLTO-NT framework and poly(ethylene carbonate)(3D-LLTO-NT@PEC)shows improved ionic conductivity of 1.73×10^(-4)S cm^(-1)at ambient temperature,higher lithium-ion transference number(t_(Li)^(+))of 0.78 and electrochemical stability window up to 5.0 V vs Li/Li^(+).The all-solid-state cell of LiFePO_(4)/3D-LLTO-NT@PEC/Li delivers a high specific capacity of 140.2 mAh g^(-1)at 0.1 C at ambient temperature.This outstanding performance is attributed to the 3D ceramic nanotubes frameworks which provide fast lithium ion transfer pathway and stable interfaces.
基金supported by the National Key S&T Special Projects(No.2018ZX09201018-024)Sichuan Province Science and Technology Plan(2019YFH0115).
文摘Ocular drug delivery remains a significant challenge that is limited by poor corneal retention and permeation,resulting in low ocular bioavailability(<5%).Worse still,the most convenient and safe route of ocular drug administration,topical administration results in a drug bioavailability of less than 1%.iRGD modified drug delivery strategies have been developed for cancer therapy,however active targeting iRGD platforms for ocular drug delivery have yet to be explored.Herein,an iRGD modified liposomes was developed for ocular drug delivery via topical administration.The results indicated that iRGD modified liposomes could prolong the corneal retention time and enhance corneal permeability in an iRGD receptor mediated manner.These findings provided a novel strategy for topical ocular drug delivery for the treatment of posterior ocular diseases.
基金the financial support from Program for Innovative Research Team(in Science and Technology)in University of Yunnan Province(IRTSTYN 2014-11)the State Ethnic Affairs Commission(12YNZ05).
文摘It was found for the first time that Cs_(2)CO_(3) serves as highly efficient catalyst for the direct hydroxylation reactions of phosphonates under mild conditions.This reaction provides an efficient approach to quaternaryα-hydroxy phosphonates,which possess intriguing biological activities and are widely used in many areas.
基金We are grateful for the financial support from the State Ethnic Affairs Commission(No.12YNZ05)Opening Fund of Key Laboratory of Ethnic Medicine Resource Chemistry(No.MZY 1117).
文摘A novel palladium/copper-catalyzed aerobic synthesis of bisaryl ketones from 1,2-diarylalkenes via C-C double bonds cleavage has been described.This reaction constitutes a new transformation from 1,2-diarylalkenes into bisaryl ketones,providing a unifying,simple and environmentally friendly complement to the available methods.
