Xyloketals,a new type of antioxidants from a marine mangrove fungus,have potential pharmacological properties.In this paper,the radical-scavenging activities of a series of synthetic xyloketals and related chromanes t...Xyloketals,a new type of antioxidants from a marine mangrove fungus,have potential pharmacological properties.In this paper,the radical-scavenging activities of a series of synthetic xyloketals and related chromanes toward 2,2-diphenyl-1-picrylhydrazyl(DPPH)and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS)were evaluated by absorption spectrometry.One of the compounds(compound 10)displayed significant antioxidative action against DPPH and ABTS.A structure-activity analysis showed that the reactive sites on these compounds correlated with a hydroxygroup and also with ketal or aromatic H substituents.Based in part on a density functional theory(DFT)calculation of compound 10,the antioxidant mechanism of this chromane was deduced as a possible radical-scavenging mechanism by a sequential proton loss electron-transfer(SPLET)process.展开更多
Coastal medicine is a promising field for research and drug development,because several natural products isolated from marine organisms have been found to be therapeutically useful in a clinical setting.In comparison ...Coastal medicine is a promising field for research and drug development,because several natural products isolated from marine organisms have been found to be therapeutically useful in a clinical setting.In comparison to terrestrial products,the merit of marine compounds arises from the diversity in their chemical structure and unique bioactivity.A recently discovered marine compound,xyloketal B,displays neuroprotective and antioxidative effects in in-vitro and in-vivo experimental models.It elicits these beneficial effects through mitochondrial protection,free radical scavenging,reducing reactive oxygen species production and suppressing apoptotic signaling.In addition,unpublished data from our lab revealed that transient receptor potential melastatin 7 channel activity,implicated in a myriad of neurodegenerative diseases,was inhibited following xyloketal B administration.In this review,the therapeutic effect of xyloketal B will be evaluated based on existing evidence and its potential for drug development will be also discussed.展开更多
基金supported by the National Natural Science Foundation of China(21172271)Natural Science Foundation of Guangdong Province,China(Grant No.S2011020001231)the Fundamental Research Funds for the Central Universities(11lgpy75).
文摘Xyloketals,a new type of antioxidants from a marine mangrove fungus,have potential pharmacological properties.In this paper,the radical-scavenging activities of a series of synthetic xyloketals and related chromanes toward 2,2-diphenyl-1-picrylhydrazyl(DPPH)and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS)were evaluated by absorption spectrometry.One of the compounds(compound 10)displayed significant antioxidative action against DPPH and ABTS.A structure-activity analysis showed that the reactive sites on these compounds correlated with a hydroxygroup and also with ketal or aromatic H substituents.Based in part on a density functional theory(DFT)calculation of compound 10,the antioxidant mechanism of this chromane was deduced as a possible radical-scavenging mechanism by a sequential proton loss electron-transfer(SPLET)process.
基金Supported by Canadian Institutes of Health Research(CIHR)China-Canada Joint Health Research Initiative to HSS(CIHR,FRN#132571).
文摘Coastal medicine is a promising field for research and drug development,because several natural products isolated from marine organisms have been found to be therapeutically useful in a clinical setting.In comparison to terrestrial products,the merit of marine compounds arises from the diversity in their chemical structure and unique bioactivity.A recently discovered marine compound,xyloketal B,displays neuroprotective and antioxidative effects in in-vitro and in-vivo experimental models.It elicits these beneficial effects through mitochondrial protection,free radical scavenging,reducing reactive oxygen species production and suppressing apoptotic signaling.In addition,unpublished data from our lab revealed that transient receptor potential melastatin 7 channel activity,implicated in a myriad of neurodegenerative diseases,was inhibited following xyloketal B administration.In this review,the therapeutic effect of xyloketal B will be evaluated based on existing evidence and its potential for drug development will be also discussed.
