Actin filaments play important physiological functions,which have become potential targets of antitumor drugs.Using chemicals to intervene their polymerization-depolymerization dynamics would generate new strategies f...Actin filaments play important physiological functions,which have become potential targets of antitumor drugs.Using chemicals to intervene their polymerization-depolymerization dynamics would generate new strategies for designing antitumor drugs.In this report,an artificial water channel appending acetazolamide moiety,a ligand that can selectively bind to carbonic anhydrase IX,has been prepared.展开更多
基金Financial support from the National Natural Science Foundation of China(NSFC,Grant Nos.21971046,and 21921003)the Science and Technology Commission of Shanghai Municipality(STCSM,Grant No.22JC1403700)is gratefully acknowledged.
文摘Actin filaments play important physiological functions,which have become potential targets of antitumor drugs.Using chemicals to intervene their polymerization-depolymerization dynamics would generate new strategies for designing antitumor drugs.In this report,an artificial water channel appending acetazolamide moiety,a ligand that can selectively bind to carbonic anhydrase IX,has been prepared.
