Dear Editor, Insulin secretion by pancreatic β-cells is modulated by altering the cellular content and distribution of cholesterol, which is tightly regulated by a network of transcription factors, enzymes, receptors...Dear Editor, Insulin secretion by pancreatic β-cells is modulated by altering the cellular content and distribution of cholesterol, which is tightly regulated by a network of transcription factors, enzymes, receptors, transporters and cholesterol trafficking proteins. Inhibition of cellular biosynthesis by 'statin' drugs, or depletion of plasma membrane cholesterol by methyl-β-cyclodextrin (MCD), reduce glucose-stimulated insulin secretion (GSIS) and content in β-cells and islets;展开更多
文摘Dear Editor, Insulin secretion by pancreatic β-cells is modulated by altering the cellular content and distribution of cholesterol, which is tightly regulated by a network of transcription factors, enzymes, receptors, transporters and cholesterol trafficking proteins. Inhibition of cellular biosynthesis by 'statin' drugs, or depletion of plasma membrane cholesterol by methyl-β-cyclodextrin (MCD), reduce glucose-stimulated insulin secretion (GSIS) and content in β-cells and islets;