Objective:To report T1-2N0 tongue cancer recurrences initially treated with sur-gery alone. Methods:Between 1990 and 2010, 27 patients at tertiary hospital referral center institution were treated with curative intent...Objective:To report T1-2N0 tongue cancer recurrences initially treated with sur-gery alone. Methods:Between 1990 and 2010, 27 patients at tertiary hospital referral center institution were treated with curative intent for locoregional recurrence after initial glossectomy with or without neck dissection for T1-2N0 tongue cancer. None had received adjuvant postopera-tive radiation as a component of the original treatment. Results:Median time to locoregional recurrence was 12 months (range 5e39 months) and 78%of failures occurred in the first 2 years. Most treatment failures were local (63%). Salvage strat-egy was risk-adapted by individual patient. The 5-year disease specific survival (DSS) was 61%. Patients with local recurrences alone fared significantly better than those with regional recur-rences (5-yr DSS:86%vs. 22%, P Z 0.0018). Local recurrences were usually treated by surgery alone, while regional recurrences were more commonly treated with combined modality treat-ment (PZ 0.005).Conclusions:Recurrence of early stage oral tongue cancer can be successfully salvaged in a majority of cases. Patients developing regional recurrence have significantly worse prognosis than those with local failures.展开更多
文摘Objective:To report T1-2N0 tongue cancer recurrences initially treated with sur-gery alone. Methods:Between 1990 and 2010, 27 patients at tertiary hospital referral center institution were treated with curative intent for locoregional recurrence after initial glossectomy with or without neck dissection for T1-2N0 tongue cancer. None had received adjuvant postopera-tive radiation as a component of the original treatment. Results:Median time to locoregional recurrence was 12 months (range 5e39 months) and 78%of failures occurred in the first 2 years. Most treatment failures were local (63%). Salvage strat-egy was risk-adapted by individual patient. The 5-year disease specific survival (DSS) was 61%. Patients with local recurrences alone fared significantly better than those with regional recur-rences (5-yr DSS:86%vs. 22%, P Z 0.0018). Local recurrences were usually treated by surgery alone, while regional recurrences were more commonly treated with combined modality treat-ment (PZ 0.005).Conclusions:Recurrence of early stage oral tongue cancer can be successfully salvaged in a majority of cases. Patients developing regional recurrence have significantly worse prognosis than those with local failures.
