Metastasis to distant sites is a severe treatment challenge and a major cause of death for breast cancer patients.Laser immunotherapy(LIT)is a novel technique,combining a selective photothermal therapy with local appl...Metastasis to distant sites is a severe treatment challenge and a major cause of death for breast cancer patients.Laser immunotherapy(LIT)is a novel technique,combining a selective photothermal therapy with local application of glycated chitosan,a potent immunoadjuvant.The pre-clinical studies of LIT have shown its unique characteristics in generating specific antitumor immunity.The clinical application of LIT in the treatment of melanoma patients has achieved preliminary success.Recently,LIT has been used to treat late-stage breast cancer patients.Here we report for the first time the clinical results of this combination therapy in breast cancer patients.The LIT treatment procedures are presented and the medical history of two stage Ⅳ breast cancer patients is reviewed.Most of the breast cancer lesions and the metastasis of lung and brain disappeared after repeated treatments of LIT.One patient achieved complete response;the other achieved partial response at the time of this report.Although there is still a long way for LIT to become a standard modality for breast cancer treatment,the results of this study indicated its promising future.展开更多
Cronkhite-Canada syndrome is a rare,hamartomatous polyposis syndrome of unknown etiology.Hamartomatous gastrointestinal polyps,alopecia,onychodystrophy,cutaneous hyperpigmentation,abdominal pain,diarrhea,and complicat...Cronkhite-Canada syndrome is a rare,hamartomatous polyposis syndrome of unknown etiology.Hamartomatous gastrointestinal polyps,alopecia,onychodystrophy,cutaneous hyperpigmentation,abdominal pain,diarrhea,and complications of weight loss are typical of the syndrome.In this report,we describe a pathological finding of colonic adenomatous polyposis as opposed to hamartomatous polyposis.We also describe our treatment,long-term therapeutic plan,and the need for further research.展开更多
基金supported in part by a grant from the US National Institutes of Health(P20 RR016478 from the INBRE Program of the National Center for Research Resources).
文摘Metastasis to distant sites is a severe treatment challenge and a major cause of death for breast cancer patients.Laser immunotherapy(LIT)is a novel technique,combining a selective photothermal therapy with local application of glycated chitosan,a potent immunoadjuvant.The pre-clinical studies of LIT have shown its unique characteristics in generating specific antitumor immunity.The clinical application of LIT in the treatment of melanoma patients has achieved preliminary success.Recently,LIT has been used to treat late-stage breast cancer patients.Here we report for the first time the clinical results of this combination therapy in breast cancer patients.The LIT treatment procedures are presented and the medical history of two stage Ⅳ breast cancer patients is reviewed.Most of the breast cancer lesions and the metastasis of lung and brain disappeared after repeated treatments of LIT.One patient achieved complete response;the other achieved partial response at the time of this report.Although there is still a long way for LIT to become a standard modality for breast cancer treatment,the results of this study indicated its promising future.
文摘Cronkhite-Canada syndrome is a rare,hamartomatous polyposis syndrome of unknown etiology.Hamartomatous gastrointestinal polyps,alopecia,onychodystrophy,cutaneous hyperpigmentation,abdominal pain,diarrhea,and complications of weight loss are typical of the syndrome.In this report,we describe a pathological finding of colonic adenomatous polyposis as opposed to hamartomatous polyposis.We also describe our treatment,long-term therapeutic plan,and the need for further research.
