Spinal cord injury(SCI)is a highly devastating and com plex inj u ry with many seconda ry consequences.Finding a treatment for SCI has been a rollercoaster ride through exciting peaks and sobering valleys.As a matter ...Spinal cord injury(SCI)is a highly devastating and com plex inj u ry with many seconda ry consequences.Finding a treatment for SCI has been a rollercoaster ride through exciting peaks and sobering valleys.As a matter of fact,there are still no robust and reliable clinical treatments to minimize or repair spinal cord damage.展开更多
The complex and variable nature of traumatic spinal cord inju- ry （SCI） presents a unique challenge for translational research. SCI is not bound by any demographic nor is it limited to specific injury biomechanics.
Spinal cord injury(SCI)induces a robust inflammatory response largely mediated by resident microglia and infiltrating macrophages across the blood-brain barrier.While these cell populations are capable of promoting re...Spinal cord injury(SCI)induces a robust inflammatory response largely mediated by resident microglia and infiltrating macrophages across the blood-brain barrier.While these cell populations are capable of promoting repair and regenerative responses,in the days and weeks after SCI they predominately adopt pro-inflammatory profiles known to inhibit recovery and potentiate secondary injury pathways.展开更多
基金supported by NIH,Nos.NIH R01 NS116068(to JCG)and NIH T32 NS077889(to OHW)。
文摘Spinal cord injury(SCI)is a highly devastating and com plex inj u ry with many seconda ry consequences.Finding a treatment for SCI has been a rollercoaster ride through exciting peaks and sobering valleys.As a matter of fact,there are still no robust and reliable clinical treatments to minimize or repair spinal cord damage.
文摘The complex and variable nature of traumatic spinal cord inju- ry （SCI） presents a unique challenge for translational research. SCI is not bound by any demographic nor is it limited to specific injury biomechanics.
基金supported by National Institute of Neurological Disorders and Stroke(NINDS)R01NS091582,NINDS T32 NS077889,and NINDS F31 NS105443。
文摘Spinal cord injury(SCI)induces a robust inflammatory response largely mediated by resident microglia and infiltrating macrophages across the blood-brain barrier.While these cell populations are capable of promoting repair and regenerative responses,in the days and weeks after SCI they predominately adopt pro-inflammatory profiles known to inhibit recovery and potentiate secondary injury pathways.
