AIM: To examine the results of orthotopic liver transplantation(OLT) for hepatocellular carcinoma(HCC) in Ireland over a 14-year period.METHODS: Cases of HCC receiving OLT between January 1995 and September 2009 in th...AIM: To examine the results of orthotopic liver transplantation(OLT) for hepatocellular carcinoma(HCC) in Ireland over a 14-year period.METHODS: Cases of HCC receiving OLT between January 1995 and September 2009 in the Irish Liver Transplant Unit were reviewed from a prospectively maintained database. Outcome measures included overall and recurrence free survival, alpha-fetoprotein(AFP) and tumour pathological features. RESULTS: On explant pathology, 57 patients had HCC. The median follow-up time was 42.7 mo. The overall 1, 3 and 5 years survival was 87.7%, 72.1% and 72.4%. There was no difference in survival when comparedto patients undergoing OLT without malignancy. The tumour recurrence rate was 14%. The Milan criteria were exceeded in 32% of cases but this did not predict overall survival or recurrence. On multivariate analysis pre-operative AFP > 100 ng/m L was an independent risk factor for recurrence(RR = 5.2, CI: 1.1-24.3, P = 0.036).CONCLUSION: Patients undergoing OLT for HCC had excellent survival even when conventional listing criteria were exceeded. Pre-operative AFP predicts recurrence independent of tumour size and its role in selection criteria should be investigated in larger studies.展开更多
戛纳时间2015年6月24日上午10点#We have a plan#的专场,电影制作者、人道主义者、活动家Richard Curtis与全球著名的创意热店BBH（Bartle Bogle Hegarty,中文名“百比赫”）创始人John Hegarty探讨了WEHAVEAPLAN（我们有个计划）,这个6...戛纳时间2015年6月24日上午10点#We have a plan#的专场,电影制作者、人道主义者、活动家Richard Curtis与全球著名的创意热店BBH（Bartle Bogle Hegarty,中文名“百比赫”）创始人John Hegarty探讨了WEHAVEAPLAN（我们有个计划）,这个60秒广告利用大屏到达全球电影观众,旨在7天内到达70亿人口,将成为有史以来首个全球电影广告活动。展开更多
文摘AIM: To examine the results of orthotopic liver transplantation(OLT) for hepatocellular carcinoma(HCC) in Ireland over a 14-year period.METHODS: Cases of HCC receiving OLT between January 1995 and September 2009 in the Irish Liver Transplant Unit were reviewed from a prospectively maintained database. Outcome measures included overall and recurrence free survival, alpha-fetoprotein(AFP) and tumour pathological features. RESULTS: On explant pathology, 57 patients had HCC. The median follow-up time was 42.7 mo. The overall 1, 3 and 5 years survival was 87.7%, 72.1% and 72.4%. There was no difference in survival when comparedto patients undergoing OLT without malignancy. The tumour recurrence rate was 14%. The Milan criteria were exceeded in 32% of cases but this did not predict overall survival or recurrence. On multivariate analysis pre-operative AFP > 100 ng/m L was an independent risk factor for recurrence(RR = 5.2, CI: 1.1-24.3, P = 0.036).CONCLUSION: Patients undergoing OLT for HCC had excellent survival even when conventional listing criteria were exceeded. Pre-operative AFP predicts recurrence independent of tumour size and its role in selection criteria should be investigated in larger studies.
文摘戛纳时间2015年6月24日上午10点#We have a plan#的专场,电影制作者、人道主义者、活动家Richard Curtis与全球著名的创意热店BBH（Bartle Bogle Hegarty,中文名“百比赫”）创始人John Hegarty探讨了WEHAVEAPLAN（我们有个计划）,这个60秒广告利用大屏到达全球电影观众,旨在7天内到达70亿人口,将成为有史以来首个全球电影广告活动。
