In December 2019,initial cases of the novel coronavirus(2019-nCoV)infection,termed coronavirus disease 2019(COVID-19),were first reported in Wuhan,China.[1]In humans,infections with the human coronavirus 229E,OC43,NL6...In December 2019,initial cases of the novel coronavirus(2019-nCoV)infection,termed coronavirus disease 2019(COVID-19),were first reported in Wuhan,China.[1]In humans,infections with the human coronavirus 229E,OC43,NL63,and HKU1 usually result in mild,selflimiting upper respiratory tract infections.However,other variants have rapid transmission rates and can cause severe respiratory syndrome and death.These variants include severe acute respiratory syndrome coronavirus(SARSCoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and the current 2019-nCoV.展开更多
Human immunodeficiency virus(HIV)has been shown to evolve independently in different anatomical compartments.Characterizing HIV genetic evolution in different tissues and cells provides insights into the mechanisms th...Human immunodeficiency virus(HIV)has been shown to evolve independently in different anatomical compartments.Characterizing HIV genetic evolution in different tissues and cells provides insights into the mechanisms that maintain the viral reservoir.HIV compartmentalization has been well documented in the semen but rarely in male genital tract(MGT)organs.The precise mechanisms that result in the development of HIV compartmentalization in multiple genitourinary sites have been poorly explored due to the difficulty in accessing these tissues.Based on evidence from lymph nodes and gut tissues,mechanisms that may influence compartmentalization include immune pressures,local concentrations of antiviral drugs,clonal expansion of different cell types and inflammation that alters the cellular microenvironment.We reviewed phylogenetic evidences supporting viral compartmentalization between the blood and multiple genitourinary sites in HIV-infected people.Characterizing distinct viral subpopulations enhances our overall understanding of the HIV reservoir inMGTand could ultimately lead to the development of novel therapies to eradicate the virus in tissues.展开更多
近日,英国皇家建筑师学会(The Royal Institute of British Architects,简称R旧A),颁布了2021年获奖名单:其中,总统研究奖(WBA President’s Award for Research)的得主是来自香港大学的林君翰(John Lin)和索尼·德巴克托尼(Sony De...近日,英国皇家建筑师学会(The Royal Institute of British Architects,简称R旧A),颁布了2021年获奖名单:其中,总统研究奖(WBA President’s Award for Research)的得主是来自香港大学的林君翰(John Lin)和索尼·德巴克托尼(Sony Devabhaktuni),他们的项目是As found house:来自中国农村的自建者的实验。展开更多
基金This work was funded by grants from the Chongqing Special Research Project for Prevention and Control of Novel Coronavirus Pneumonia(No.cstc2020jscxfyzx0074)the Canadian Institutes of Health Research(No.HB2164064).
文摘In December 2019,initial cases of the novel coronavirus(2019-nCoV)infection,termed coronavirus disease 2019(COVID-19),were first reported in Wuhan,China.[1]In humans,infections with the human coronavirus 229E,OC43,NL63,and HKU1 usually result in mild,selflimiting upper respiratory tract infections.However,other variants have rapid transmission rates and can cause severe respiratory syndrome and death.These variants include severe acute respiratory syndrome coronavirus(SARSCoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and the current 2019-nCoV.
基金This work was funded by the China Scholarship Council(No.201906325018)the Canadian Institutes of Health Research(CIHR+3 种基金grants MOP 103230 and PTJ 166049)the Vaccines&Immunotherapy Core of the CIHR Canadian HIV Trials Network(CTN,grant CTN 257)the CIHR-funded Canadian HIV Cure Enterprise(CanCURE)Team Grant HB2-164064This work was also supported by the Fonds de la Recherche Quebec-Sante(FRQ-S):Reseau SIDA/Maladies infectieuses and Therapie cellulaire.Stephane Isnard is supported by a Fond de Recherche Quebec Santefellowship and a CIHR/CTN Postdoctoral Fellowship Award.Jean-Pierre Routy is the holder of the Louis Lowenstein Chair in Hematology and Oncology,McGill University and William Turner award holder from the McGill University Health Centre.
文摘Human immunodeficiency virus(HIV)has been shown to evolve independently in different anatomical compartments.Characterizing HIV genetic evolution in different tissues and cells provides insights into the mechanisms that maintain the viral reservoir.HIV compartmentalization has been well documented in the semen but rarely in male genital tract(MGT)organs.The precise mechanisms that result in the development of HIV compartmentalization in multiple genitourinary sites have been poorly explored due to the difficulty in accessing these tissues.Based on evidence from lymph nodes and gut tissues,mechanisms that may influence compartmentalization include immune pressures,local concentrations of antiviral drugs,clonal expansion of different cell types and inflammation that alters the cellular microenvironment.We reviewed phylogenetic evidences supporting viral compartmentalization between the blood and multiple genitourinary sites in HIV-infected people.Characterizing distinct viral subpopulations enhances our overall understanding of the HIV reservoir inMGTand could ultimately lead to the development of novel therapies to eradicate the virus in tissues.
文摘近日,英国皇家建筑师学会(The Royal Institute of British Architects,简称R旧A),颁布了2021年获奖名单:其中,总统研究奖(WBA President’s Award for Research)的得主是来自香港大学的林君翰(John Lin)和索尼·德巴克托尼(Sony Devabhaktuni),他们的项目是As found house:来自中国农村的自建者的实验。
