目的:动态光学乳腺成像技术(dynamic optical breast imaging,DOBI)对乳腺癌诊断指标进行初步探讨。材料和方法:接受DOBI及乳腺活检的患者共52例,均为女性。乳腺癌组19例,非乳腺癌组33例。结果:非乳腺癌感兴趣区内的"蓝色病灶"...目的:动态光学乳腺成像技术(dynamic optical breast imaging,DOBI)对乳腺癌诊断指标进行初步探讨。材料和方法:接受DOBI及乳腺活检的患者共52例,均为女性。乳腺癌组19例,非乳腺癌组33例。结果:非乳腺癌感兴趣区内的"蓝色病灶"85.42%为漂移或发散,而乳腺癌68.42%为聚焦;非乳腺癌的"蓝色病灶"代谢曲线86.46%为平缓下降或呈波浪状,而乳腺癌以直线下降为多,达57.37%;64.58%非乳腺癌感兴趣区内的"蓝色病灶"代谢曲线与非蓝区代谢曲线相同,78.95%乳腺癌患者的代谢曲线与非蓝区代谢曲线不同;乳腺癌患者"蓝色病灶"代谢值(平均值为-5.77±2.13)的绝对值明显高于非乳腺癌患者(平均值为-3.34±0.87;P<0.05)。结论:DOBI空间特征的局限、聚焦且稳定、代谢曲线呈陡直下降对恶性或可疑恶性病变诊断价值更大,其次为代谢值的绝对值较大(多大于|-5|)。展开更多
Objective: To study the frequency of interstitial 7q deletions in B-cell lymphoproliferative disorders (B-LPDs). Methods: Cases were collected from the clinical laboratory diagnosis database at USLabs/LabCorp over the...Objective: To study the frequency of interstitial 7q deletions in B-cell lymphoproliferative disorders (B-LPDs). Methods: Cases were collected from the clinical laboratory diagnosis database at USLabs/LabCorp over the past two years (2002 to 2004). Cases that showed deletions in the long arm of chromosome 7 were then reviewed. Interstitial deletions in the long arm of chromosome 7 were further investigated according to the indications for clinical laboratory studies and flow cytometry findings. The final clinical diagnosis for each case was obtained from the referring physician. Results: A total of 19 483 cases were included in this series. Eighty-five cases were observed to have either terminal or interstitial deletion in the long arm of chromosome 7. Of the 85 cases, 46 had interstitial deletions accounting for 54.1% of the 7q deletions combined. B-LPDs were found in 10 of the 46 cases, accounting for 21.7%. The B-LPDs associated with 7q interstitial deletions were diverse, including B-cell chronic lymphocytic leukemia (B-CLL) in five cases. The deleted region in the long arm of chromosome 7 in the 10 cases associated with B-LPDs was solely confined to the 7q22-q32 region. Conclusion: (1) The frequency of 7q interstitial deletions associated with B-LPDs is substantially high; (2) 7q interstitial deletions are not uncommon in B-CLL.展开更多
文摘目的:动态光学乳腺成像技术(dynamic optical breast imaging,DOBI)对乳腺癌诊断指标进行初步探讨。材料和方法:接受DOBI及乳腺活检的患者共52例,均为女性。乳腺癌组19例,非乳腺癌组33例。结果:非乳腺癌感兴趣区内的"蓝色病灶"85.42%为漂移或发散,而乳腺癌68.42%为聚焦;非乳腺癌的"蓝色病灶"代谢曲线86.46%为平缓下降或呈波浪状,而乳腺癌以直线下降为多,达57.37%;64.58%非乳腺癌感兴趣区内的"蓝色病灶"代谢曲线与非蓝区代谢曲线相同,78.95%乳腺癌患者的代谢曲线与非蓝区代谢曲线不同;乳腺癌患者"蓝色病灶"代谢值(平均值为-5.77±2.13)的绝对值明显高于非乳腺癌患者(平均值为-3.34±0.87;P<0.05)。结论:DOBI空间特征的局限、聚焦且稳定、代谢曲线呈陡直下降对恶性或可疑恶性病变诊断价值更大,其次为代谢值的绝对值较大(多大于|-5|)。
文摘Objective: To study the frequency of interstitial 7q deletions in B-cell lymphoproliferative disorders (B-LPDs). Methods: Cases were collected from the clinical laboratory diagnosis database at USLabs/LabCorp over the past two years (2002 to 2004). Cases that showed deletions in the long arm of chromosome 7 were then reviewed. Interstitial deletions in the long arm of chromosome 7 were further investigated according to the indications for clinical laboratory studies and flow cytometry findings. The final clinical diagnosis for each case was obtained from the referring physician. Results: A total of 19 483 cases were included in this series. Eighty-five cases were observed to have either terminal or interstitial deletion in the long arm of chromosome 7. Of the 85 cases, 46 had interstitial deletions accounting for 54.1% of the 7q deletions combined. B-LPDs were found in 10 of the 46 cases, accounting for 21.7%. The B-LPDs associated with 7q interstitial deletions were diverse, including B-cell chronic lymphocytic leukemia (B-CLL) in five cases. The deleted region in the long arm of chromosome 7 in the 10 cases associated with B-LPDs was solely confined to the 7q22-q32 region. Conclusion: (1) The frequency of 7q interstitial deletions associated with B-LPDs is substantially high; (2) 7q interstitial deletions are not uncommon in B-CLL.
