Recently there have been several major advances in our understanding of pathophysiological mechanisms in primary afferent nociceptors that may contribute to enhanced nociception (hyperalgesia) in response to injury, i...Recently there have been several major advances in our understanding of pathophysiological mechanisms in primary afferent nociceptors that may contribute to enhanced nociception (hyperalgesia) in response to injury, in a variety of clinical states. These include contributions of specific second messenger signaling pathways and ionic conductances. Important roles for specific second messenger systems in acute primary展开更多
文摘Recently there have been several major advances in our understanding of pathophysiological mechanisms in primary afferent nociceptors that may contribute to enhanced nociception (hyperalgesia) in response to injury, in a variety of clinical states. These include contributions of specific second messenger signaling pathways and ionic conductances. Important roles for specific second messenger systems in acute primary
