PURPOSE: To determine the prevalence of full-thickness macular holes in the elderly Chinese population. DESIGN: Population-based,cross-sectional cohort study. METHODS: The Beijing Eye Study included 4439 subjects out ...PURPOSE: To determine the prevalence of full-thickness macular holes in the elderly Chinese population. DESIGN: Population-based,cross-sectional cohort study. METHODS: The Beijing Eye Study included 4439 subjects out of 5324 subjects invited to participate (response rate 83.4% ) aged 40 years or older. The present investigation consisted of 8653 (97.9% ) eyes of 4346 subjects for whom readable fundus photographs were available. RESULTS: Full-thickness macular holes were found in eight (0.092% ) eyes of seven (0.16% )-patients (six women). Prevalence was 0.09± 3.04% 95% confidence interval (CI): 0.03,0.16% . CONCLUSIONS: Fullthickness macular holes may be present in approximately 1.6 out of 1000 elderly Chinese in Northern China. Calculated for the entire population in China,the figure would be approximately 750,000 patients with unilateral full-thickness macular holes 650,000 (95% CI: 217,000 to 1,156,000) or bilateral full-thickness macular holes 100,000 (95% CI: 33,000 to 178,000).展开更多
PURPOSE: To evaluate the rate of infectious and noninfectious endophthalmitis after intravitreal injection of a high-dosage of triamcinolone acetonide. DESIGN: Clinical interventional case-series study. METHODS: The s...PURPOSE: To evaluate the rate of infectious and noninfectious endophthalmitis after intravitreal injection of a high-dosage of triamcinolone acetonide. DESIGN: Clinical interventional case-series study. METHODS: The study included 1135 intravitreal injections of approximately 20 mg triamcinolone performed for 915 eyes with diabetic macular edema (n=257),exudative age-related macular degeneration (n=561),retinal vein occlusions (n=82),and other reasons. Among the injections were 220 reinjections. Triamcinolone was filtered to remove the solvent agent. Mean follow-up was 8.1± 7.4 months. RESULTS: In none of the eyes,signs of an infectious or noninfectious endophthalmitis were observed such as noncrystalline hypopyon,cellular infiltration,or amorphous opacification of the vitreous,retinal infiltration,or pain. One patient developed infectious endophthalmitis 2 days after a traumatic rupture of a previous corneoscleral cataract incision. CONCLUSIONS: The rate of infectious or noninfectious endophthalmitis after an intravitreal high-dosage triamcinolone injection may be approximately 1:1000,if the solvent agent was removed.展开更多
文摘PURPOSE: To determine the prevalence of full-thickness macular holes in the elderly Chinese population. DESIGN: Population-based,cross-sectional cohort study. METHODS: The Beijing Eye Study included 4439 subjects out of 5324 subjects invited to participate (response rate 83.4% ) aged 40 years or older. The present investigation consisted of 8653 (97.9% ) eyes of 4346 subjects for whom readable fundus photographs were available. RESULTS: Full-thickness macular holes were found in eight (0.092% ) eyes of seven (0.16% )-patients (six women). Prevalence was 0.09± 3.04% 95% confidence interval (CI): 0.03,0.16% . CONCLUSIONS: Fullthickness macular holes may be present in approximately 1.6 out of 1000 elderly Chinese in Northern China. Calculated for the entire population in China,the figure would be approximately 750,000 patients with unilateral full-thickness macular holes 650,000 (95% CI: 217,000 to 1,156,000) or bilateral full-thickness macular holes 100,000 (95% CI: 33,000 to 178,000).
文摘PURPOSE: To evaluate the rate of infectious and noninfectious endophthalmitis after intravitreal injection of a high-dosage of triamcinolone acetonide. DESIGN: Clinical interventional case-series study. METHODS: The study included 1135 intravitreal injections of approximately 20 mg triamcinolone performed for 915 eyes with diabetic macular edema (n=257),exudative age-related macular degeneration (n=561),retinal vein occlusions (n=82),and other reasons. Among the injections were 220 reinjections. Triamcinolone was filtered to remove the solvent agent. Mean follow-up was 8.1± 7.4 months. RESULTS: In none of the eyes,signs of an infectious or noninfectious endophthalmitis were observed such as noncrystalline hypopyon,cellular infiltration,or amorphous opacification of the vitreous,retinal infiltration,or pain. One patient developed infectious endophthalmitis 2 days after a traumatic rupture of a previous corneoscleral cataract incision. CONCLUSIONS: The rate of infectious or noninfectious endophthalmitis after an intravitreal high-dosage triamcinolone injection may be approximately 1:1000,if the solvent agent was removed.
