A flexible,thin-film microchannel electrode array device for selective subdiaphragmatic vagus nerve recording

The vagus nerve(VN)plays an important role in regulating physiological conditions in the gastrointestinal(GI)tract by communicating via the parasympathetic pathway to the enteric nervous system(ENS).However,the lack of knowledge in the neurophysiology of the VN and GI tract limits the development of advanced treatments for autonomic dysfunctions related to the VN.To better understand the complicated underlying mechanisms of the VN-GI tract neurophysiology,it is necessary to use an advanced device enabled by microfabrication technologies.Among several candidates including intraneural probe array and extraneural cuff electrodes,microchannel electrode array devices can be used to interface with smaller numbers of nerve fibers by securing them in the separate channel structures.Previous microchannel electrode array devices to interface teased nerve structures are relatively bulky with thickness around 200µm.The thick design can potentially harm the delicate tissue structures,including the nerve itself.In this paper,we present a flexible thin film based microchannel electrode array device(thickness:11.5µm)that can interface with one of the subdiaphragmatic nerve branches of the VN in a rat.We demonstrated recording evoked compound action potentials(ECAP)from a transected nerve ending that has multiple nerve fibers.Moreover,our analysis confirmed that the signals are from C-fibers that are critical in regulating autonomic neurophysiology in the GI tract.

Ultra-stable and tough bioinspired crack-based tactile sensor for small legged robots

For legged robots,collecting tactile information is essential for stable posture and efficient gait.However,mounting sensors on small robots weighing less than 1 kg remain challenges in terms of the sensor’s durability,flexibility,sensitivity,and size.Crackbased sensors featuring ultra-sensitivity,small-size,and flexibility could be a promising candidate,but performance degradation due to crack growing by repeated use is a stumbling block.This paper presents an ultra-stable and tough bio-inspired crack-based sensor by controlling the crack depth using silver nanowire(Ag NW)mesh as a crack stop layer.The Ag NW mesh inspired by skin collagen structure effectively mitigated crack propagation.The sensor was very thin,lightweight,sensitive,and ultra-durable that maintains its sensitivity during 200,000 cycles of 0.5%strain.We demonstrate sensor’s feasibility by implementing the tactile sensation to bio-inspired robots,and propose statistical and deep learning-based analysis methods which successfully distinguished terrain type.