BACKGROUND Blood-brain barrier(BBB)disruption plays an important role in the development of neurological dysfunction in ischemic stroke.However,diagnostic modalities that can clearly diagnose the degree of BBB disrupt...BACKGROUND Blood-brain barrier(BBB)disruption plays an important role in the development of neurological dysfunction in ischemic stroke.However,diagnostic modalities that can clearly diagnose the degree of BBB disruption in ischemic stroke are limited.Here,we describe two cases in which the usefulness of dynamic contrastenhanced magnetic resonance imaging(DCE-MRI)in detecting BBB disruption was evaluated after treatment of acute ischemic stroke using two different methods.CASE SUMMARY The two patients of similar age and relatively similar cerebral infarction locations were treated conservatively or with thrombectomy,although their sex was different.As a result of analysis by performing DCE-MRI,it was confirmed that BBB disruption was significantly less severe in the patient who underwent thrombectomy(P=3.3×10^(-7)),whereas the average Ktrans of the contralateral hemisphere in both patients was similar(2.4×10^(-5)min^(-1) and 2.0×10^(-5)min^(-1)).If reperfusion is achieved through thrombectomy,it may indicate that the penumbra can be saved and BBB recovery can be promoted.CONCLUSION Our cases suggest that BBB disruption could be important if BBB permeability is used to guide clinical treatment.展开更多
1.Introduction Electric vehicles(EVs)are playing an increasingly important role in decarbonizing the transportation sector.They constitute a promising solution to a set of global challenges such as climate change and ...1.Introduction Electric vehicles(EVs)are playing an increasingly important role in decarbonizing the transportation sector.They constitute a promising solution to a set of global challenges such as climate change and air pollution.EVs are an integration of a wide spectrum of techniques,such as battery monitoring,battery safety and vehicle energy management.In this regard,the EV development still faces significant challenges,which necessitate innovations in EV technologies.Given this,Green Energy and Intelligent Transportation(GEITS)organizes a special issue of“Key Technologies for Electric Vehicles”that attempts to advance knowledge in the area of EVs and provides a platform for researchers and engineers to share recent research results and discuss critical challenges in this field.A wide spectrum of topics are discussed,including but not limited to the following.展开更多
基金Supported by the National Research Foundation of Korea grant,No.2019M3E5D1A02069399
文摘BACKGROUND Blood-brain barrier(BBB)disruption plays an important role in the development of neurological dysfunction in ischemic stroke.However,diagnostic modalities that can clearly diagnose the degree of BBB disruption in ischemic stroke are limited.Here,we describe two cases in which the usefulness of dynamic contrastenhanced magnetic resonance imaging(DCE-MRI)in detecting BBB disruption was evaluated after treatment of acute ischemic stroke using two different methods.CASE SUMMARY The two patients of similar age and relatively similar cerebral infarction locations were treated conservatively or with thrombectomy,although their sex was different.As a result of analysis by performing DCE-MRI,it was confirmed that BBB disruption was significantly less severe in the patient who underwent thrombectomy(P=3.3×10^(-7)),whereas the average Ktrans of the contralateral hemisphere in both patients was similar(2.4×10^(-5)min^(-1) and 2.0×10^(-5)min^(-1)).If reperfusion is achieved through thrombectomy,it may indicate that the penumbra can be saved and BBB recovery can be promoted.CONCLUSION Our cases suggest that BBB disruption could be important if BBB permeability is used to guide clinical treatment.
基金Beijing Natural Science Foundation(Grant No.L223013)National Natural Science Foundation of China(Grant No.52107222).
文摘1.Introduction Electric vehicles(EVs)are playing an increasingly important role in decarbonizing the transportation sector.They constitute a promising solution to a set of global challenges such as climate change and air pollution.EVs are an integration of a wide spectrum of techniques,such as battery monitoring,battery safety and vehicle energy management.In this regard,the EV development still faces significant challenges,which necessitate innovations in EV technologies.Given this,Green Energy and Intelligent Transportation(GEITS)organizes a special issue of“Key Technologies for Electric Vehicles”that attempts to advance knowledge in the area of EVs and provides a platform for researchers and engineers to share recent research results and discuss critical challenges in this field.A wide spectrum of topics are discussed,including but not limited to the following.
