mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium(TPP), which is a delocalized cationic...mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium(TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Other moieties, including short peptides,dequalinium, guanidine, rhodamine, and F16, are also known to be promising mitochondrial targeting agents. Direct conjugation of mitochondrial targeting moieties to anticancer drugs, antioxidants and sensors results in increased cytotoxicity, anti-oxidizing activity and sensing activity, respectively,compared with their non-targeting counterparts, especially in drug-resistant cells. Although many mitochondria-targeted anticancer drug conjugates have been investigated in vitro and in vivo, further clinical studies are still needed. On the other hand, several mitochondria-targeting antioxidants have been analyzed in clinical phases I, II and III trials, and one conjugate has been approved for treating eye disease in Russia. There are numerous ongoing studies of mitochondria-targeted sensors.展开更多
Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type 30.The current s...Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type 30.The current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus 30.Methods:Two hundred and fifty residual serum samples were collected at St.Paul's Hospital.Individuals were categorized by age into four groups:group 1 (3 months-2 years),group 2 (3-6 years),group 3 (7-10 years) and group 4 (11-15 years).Neutralizing antibodies against echovirus 30 were measured.Results:Seroprotective neutralizing antibodies against echovirus 30 were detected in 129 (49%) individuals.Seropositivity rates were 23%,48%,55% and 73% in groups 1-4,respectively.For antibody titers,1:256-1:512 was the highest neutralizing antibody titer range in group 2,while 1:1024-1:2048 in group 3 and 4.Among the seropositive individuals in group 3 and 4,6% and 12% had neutralizing antibody titers of 1:2048,respectively.Conclusions:The seropositivity rate increased significantly with age..The distribution of neutralizing antibody titers varied by age group,and higher ranges of neutralizing antibody titers were observed in higher age groups.These findings suggest high susceptibility to echovirus 30 infection in children younger than 2 years old.Echovirus 30 infection in childhood may have contributed to increased neutralizing antibody titers with age.展开更多
基金supported by the National Research Foundation of Korea (NRF)funded by the Korean government (MSIT) (NRF2017R1A4A1015036 and NRF-2015R1A1A05001459)the study was supported by BK21PLUS grant of NRF funded by the Korean government (ME) (22A20130012250)
文摘mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium(TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Other moieties, including short peptides,dequalinium, guanidine, rhodamine, and F16, are also known to be promising mitochondrial targeting agents. Direct conjugation of mitochondrial targeting moieties to anticancer drugs, antioxidants and sensors results in increased cytotoxicity, anti-oxidizing activity and sensing activity, respectively,compared with their non-targeting counterparts, especially in drug-resistant cells. Although many mitochondria-targeted anticancer drug conjugates have been investigated in vitro and in vivo, further clinical studies are still needed. On the other hand, several mitochondria-targeting antioxidants have been analyzed in clinical phases I, II and III trials, and one conjugate has been approved for treating eye disease in Russia. There are numerous ongoing studies of mitochondria-targeted sensors.
文摘Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type 30.The current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus 30.Methods:Two hundred and fifty residual serum samples were collected at St.Paul's Hospital.Individuals were categorized by age into four groups:group 1 (3 months-2 years),group 2 (3-6 years),group 3 (7-10 years) and group 4 (11-15 years).Neutralizing antibodies against echovirus 30 were measured.Results:Seroprotective neutralizing antibodies against echovirus 30 were detected in 129 (49%) individuals.Seropositivity rates were 23%,48%,55% and 73% in groups 1-4,respectively.For antibody titers,1:256-1:512 was the highest neutralizing antibody titer range in group 2,while 1:1024-1:2048 in group 3 and 4.Among the seropositive individuals in group 3 and 4,6% and 12% had neutralizing antibody titers of 1:2048,respectively.Conclusions:The seropositivity rate increased significantly with age..The distribution of neutralizing antibody titers varied by age group,and higher ranges of neutralizing antibody titers were observed in higher age groups.These findings suggest high susceptibility to echovirus 30 infection in children younger than 2 years old.Echovirus 30 infection in childhood may have contributed to increased neutralizing antibody titers with age.
