Objective: Cheongseoikki-tang (CIT, Korean), also called Qingshu Yiqi decoction(清署益气汤)and Seisho-ekki-to (Japanese), is well known as an effective traditional combination of herbs for treating cardiovascul...Objective: Cheongseoikki-tang (CIT, Korean), also called Qingshu Yiqi decoction(清署益气汤)and Seisho-ekki-to (Japanese), is well known as an effective traditional combination of herbs for treating cardiovascular diseases. This study was to research its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms. Methods: In this study, the biological effect of Cheongseoikki-tang ethanol extract (CITE) was evaluated, focusing on its effects on the production of allergic mediators by phorbol 12-myfistate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated BMMCs. These allergic mediators included intedeukin-6 (IL-6), prostaglandin D2 (PGD2), leukotfiene (34 (LTC4), and β-hexosaminidase (13-hex). Results: Our data revealed that CITE inhibited the production of IL-6, PGD2,/TC4, and 15-hex induced by PMA plus A23187 (P〈0.05). Conclusion: These findings indicate that CITE has the potential for use in the treatment of allergy.展开更多
基金Supported by the National Research Foundation of Korea Grant (No.NRF-2010-013-E00034)the Grant of the Traditional Korean Medicine R&D project,Ministry of Health & Welfare, Republic of Korea(No.B120069)
文摘Objective: Cheongseoikki-tang (CIT, Korean), also called Qingshu Yiqi decoction(清署益气汤)and Seisho-ekki-to (Japanese), is well known as an effective traditional combination of herbs for treating cardiovascular diseases. This study was to research its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms. Methods: In this study, the biological effect of Cheongseoikki-tang ethanol extract (CITE) was evaluated, focusing on its effects on the production of allergic mediators by phorbol 12-myfistate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated BMMCs. These allergic mediators included intedeukin-6 (IL-6), prostaglandin D2 (PGD2), leukotfiene (34 (LTC4), and β-hexosaminidase (13-hex). Results: Our data revealed that CITE inhibited the production of IL-6, PGD2,/TC4, and 15-hex induced by PMA plus A23187 (P〈0.05). Conclusion: These findings indicate that CITE has the potential for use in the treatment of allergy.