The AMP-activated protein kinase(AMPK)is known to maintain the integrity of cellular mitochondrial networks by(i)promoting fission,(ii)inhibiting fusion,(iii)promoting recycling of damaged components via mitophagy,(iv...The AMP-activated protein kinase(AMPK)is known to maintain the integrity of cellular mitochondrial networks by(i)promoting fission,(ii)inhibiting fusion,(iii)promoting recycling of damaged components via mitophagy,(iv)enhancing lysosomal biogenesis to support mitophagy,and(v)promoting biogenesis of new mitochondrial components.While the AMPK targets underlying the first three of these effects are known,a recent paper suggests that direct phosphorylation of the folliculin-interacting protein 1(FNIP1)by AMPK may be involved in the remaining two.展开更多
基金supported by an Investigator Award from the Wellcome Trust(204766/Z/16/Z).
文摘The AMP-activated protein kinase(AMPK)is known to maintain the integrity of cellular mitochondrial networks by(i)promoting fission,(ii)inhibiting fusion,(iii)promoting recycling of damaged components via mitophagy,(iv)enhancing lysosomal biogenesis to support mitophagy,and(v)promoting biogenesis of new mitochondrial components.While the AMPK targets underlying the first three of these effects are known,a recent paper suggests that direct phosphorylation of the folliculin-interacting protein 1(FNIP1)by AMPK may be involved in the remaining two.
