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Experimental Studies on the Irradiation of Facial Bones in Animals:A Review
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作者 Lucas Poort Bernd Lethaus +4 位作者 Roland Bockmann Doke Buurman jos de jong Frank Hoebers Peter Kessler 《International Journal of Otolaryngology and Head & Neck Surgery》 2014年第3期113-127,共15页
Introduction: Radiotherapy is often used to treat head and neck malignancies, with inevitable effects on the surrounding healthy tissues. We have reviewed the literature concerning the experimental irradiation of faci... Introduction: Radiotherapy is often used to treat head and neck malignancies, with inevitable effects on the surrounding healthy tissues. We have reviewed the literature concerning the experimental irradiation of facial bones in animals. Materials and Methods: A PubMed search was performed to retrieve animal experiments on the irradiation of facial bones that were published between January 1992 and January 2012. The search terms were “irradiation facial bone” and “irradiation osteoradionecrosis”. Results: Thirty-six publications were included. The irradiation sources were Cobalt60, orthovoltage, 4 - 6 megavolt photons, and brachytherapy. The total dose varied between 8 - 60 Gy in single or multiple fractions. The literature presents a broad range of animal studies that differ in terms of the in vivo model, irradiation, observation period, and evaluation of results. Discussion: The different animal models used leave many questions unanswered. A detailed and standardized description of the methodology and results would facilitate the comparability of future studies. 展开更多
关键词 IRRADIATION Animal Experiments Facial Bones OSTEORADIONECROSIS
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