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Trichomonas vaginalis perturbs the junctional complex in epithelial cells
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作者 Rodrigo Furtado MADEIRO da COsTA Wanderley de sOUZA +2 位作者 Marlene BENCHIMOL john F ALDERETE joséandrés morgado-díaz 《Cell Research》 SCIE CAS CSCD 2005年第9期704-716,共13页
Trichomonas vaginalis,a protist parasite of the urogenital tract in humans,is the causative agent of trichomonosis,which in recent years have been associated with the cervical cancer development.In the present study w... Trichomonas vaginalis,a protist parasite of the urogenital tract in humans,is the causative agent of trichomonosis,which in recent years have been associated with the cervical cancer development.In the present study we analyzed the modifications at the junctional complex level of Caco-2 cells after interaction with two isolates of T.vaginalis and the influence of the iron concentration present in the parasite’s culture medium on the interaction effects.Our results show that T.vaginalis adheres to the epithelial cell causing alterations in the junctional complex,such as:(a)a decrease in transepithelial electrical resistance;(b)alteration in the pattern of junctional complex proteins distribution as observed for E-cadherin,occludin and ZO-1;and(c)enlargement of the spaces between epithelial cells.These effects were dependent on(a)the degree of the parasite virulence isolate,(b)the iron concentration in the culture medium,and(c)the expression of adhesin proteins on the parasite surface. 展开更多
关键词 Trichomonas vaginalis CACO-2 junctional complex proteins transepithelial electrical resistance ADHESINS
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