Dear Editor,Short-term fasting(up to 48 hours)activates strong physiological and molecular responses[1].We and others showed a p53-independent transcriptional activation of the cell cycle inhibitor p21 upon fasting,mo...Dear Editor,Short-term fasting(up to 48 hours)activates strong physiological and molecular responses[1].We and others showed a p53-independent transcriptional activation of the cell cycle inhibitor p21 upon fasting,most strongly in the liver,muscles,and many other tissues[2,3].Studies with mice[4,5]and human patients[6]have shown the beneficial effects of short-term fasting during anti-cancer chemotherapy treatments.展开更多
基金the Spanish association against cancer(AECC)(id:SIRTBIO-LABAE18008FERN and PRDMA18011PAST)Pablo J.Fernandez-Marcos has been funded by a Ramon y Cajal Award from the Spanish Ministry of Science,Innovation and Universities(MICINN)(RYC-2017-22335)+2 种基金Marta Barradas and Cristina Pantoja have been funded by Madrid Institute for Advanced Studies(IMDEA)Food.Jose L.López-Aceituno has been funded by the Spanish Ministry of Science and Innovation(MICINN)(PTA2017-14689-I)Work at the laboratory of Pablo J.Fernandez-Marcos was funded by the AECC(SIRTBIO-LABAE18008FERN)the RETOS projects Programme of MICINN(SAF2017-85766-R and PID2020-114077RB-I00).
文摘Dear Editor,Short-term fasting(up to 48 hours)activates strong physiological and molecular responses[1].We and others showed a p53-independent transcriptional activation of the cell cycle inhibitor p21 upon fasting,most strongly in the liver,muscles,and many other tissues[2,3].Studies with mice[4,5]and human patients[6]have shown the beneficial effects of short-term fasting during anti-cancer chemotherapy treatments.
