This study reveals the interference of 177Hf, a decay product of 177Lu, in the synthesis of 177Lu-DOTAtate, In the experiments we followed three 177Lu t1/2. The molar ratio Lu： DOTAtate used was calculated for each d...This study reveals the interference of 177Hf, a decay product of 177Lu, in the synthesis of 177Lu-DOTAtate, In the experiments we followed three 177Lu t1/2. The molar ratio Lu： DOTAtate used was calculated for each decay, in two situations： 1） without considering the influence of 177Hf; 2） considering the influence of 177Hf. The results compare both the calculated molar ratio and the radionuclide incorporation yields （%） in these situations. The yields increase when 177Hf influence is considered. This suggests that 177Hf is an important competitor for DOTAtate binding site. These data are relevant in the synthesis of the radiopharmaceutical 177Lu-DOTAtate with high specific activity.展开更多
文摘This study reveals the interference of 177Hf, a decay product of 177Lu, in the synthesis of 177Lu-DOTAtate, In the experiments we followed three 177Lu t1/2. The molar ratio Lu： DOTAtate used was calculated for each decay, in two situations： 1） without considering the influence of 177Hf; 2） considering the influence of 177Hf. The results compare both the calculated molar ratio and the radionuclide incorporation yields （%） in these situations. The yields increase when 177Hf influence is considered. This suggests that 177Hf is an important competitor for DOTAtate binding site. These data are relevant in the synthesis of the radiopharmaceutical 177Lu-DOTAtate with high specific activity.
