Background:In recent years,monitoring of vitamin D levels and possible use of supplementation is gaining attention.Numerous studies showed low levels of vitamin D in winter months followed by improvement during summer...Background:In recent years,monitoring of vitamin D levels and possible use of supplementation is gaining attention.Numerous studies showed low levels of vitamin D in winter months followed by improvement during summer.These changes are mostly dependent on the level of sun exposure,but also on geographical location,genetic factors,social-economic status,quality of nutrition and environmental pollution.In this observation we found significant decrease in vitamin D levels I populations exposed to extreme environmental pollution in area of central Europe.This region is known for extreme burden from microparticles originating in chemical industry,surface coal mining and cold-based power stations.Methods:Vitamin D levels in all patients was determined by ELISA.Results:Using 540 patients in our Department of clinical immunology and allergology we measured the levels of vitamin D in 2016 to 2021 period.In only 4 patients(0.74%)we found vitamin D levels higher than 30 ng/mL.The curve of observed values does not reflect dependency on sun exposure and does not change during the year.Conclusion:We discuss the effect of environmental contaminants,lifestyle and economic and social factors.From our observations,we propose to directly supplement population with vitamin D,particularly children and seniors.展开更多
Background:Repeated infections of urinary tract manifest an increasing trend and became the most common infection in developed world.In addition,currently common increase in resistant microbes including uropathogens u...Background:Repeated infections of urinary tract manifest an increasing trend and became the most common infection in developed world.In addition,currently common increase in resistant microbes including uropathogens underlines the need for new ways of urinary tract infection(UTI)treatment.One of the possibilities is vaccination.However,commercially available bacterial vaccines are not always reliable,leading to the proposition of using autovaccines prepared from uropathogens of individual patients.It is a well-known fact that UTIs are often accompanied by depressed immunity.Methods:To respond to both problems,we tried to use yeast-derived,insoluble beta glucans for restoration of depressed immune system and acceleration of the effects of autovaccines.In all patients we repeatedly tested bacterial load in urine.In addition,from the same samples we measured the levels of inflammatory proteins,albumin,orosomukoid,IgA,C-reactive protein.Complex evaluation of inflammatory response and cellular immunity in blood was performed,too.Results:Immediately after application of the first dose we observed significant improvements of clinical conditions which were persistent throughout the entire study.Conclusions:Beta glucan is optimal addition to autovaccines,as it is natural,active,safe and inexpensive.We propose that the possibility to use beta glucans in application of autovaccines is the first step in preparation of qualitative new type of autovaccines against UTI.展开更多
文摘Background:In recent years,monitoring of vitamin D levels and possible use of supplementation is gaining attention.Numerous studies showed low levels of vitamin D in winter months followed by improvement during summer.These changes are mostly dependent on the level of sun exposure,but also on geographical location,genetic factors,social-economic status,quality of nutrition and environmental pollution.In this observation we found significant decrease in vitamin D levels I populations exposed to extreme environmental pollution in area of central Europe.This region is known for extreme burden from microparticles originating in chemical industry,surface coal mining and cold-based power stations.Methods:Vitamin D levels in all patients was determined by ELISA.Results:Using 540 patients in our Department of clinical immunology and allergology we measured the levels of vitamin D in 2016 to 2021 period.In only 4 patients(0.74%)we found vitamin D levels higher than 30 ng/mL.The curve of observed values does not reflect dependency on sun exposure and does not change during the year.Conclusion:We discuss the effect of environmental contaminants,lifestyle and economic and social factors.From our observations,we propose to directly supplement population with vitamin D,particularly children and seniors.
文摘Background:Repeated infections of urinary tract manifest an increasing trend and became the most common infection in developed world.In addition,currently common increase in resistant microbes including uropathogens underlines the need for new ways of urinary tract infection(UTI)treatment.One of the possibilities is vaccination.However,commercially available bacterial vaccines are not always reliable,leading to the proposition of using autovaccines prepared from uropathogens of individual patients.It is a well-known fact that UTIs are often accompanied by depressed immunity.Methods:To respond to both problems,we tried to use yeast-derived,insoluble beta glucans for restoration of depressed immune system and acceleration of the effects of autovaccines.In all patients we repeatedly tested bacterial load in urine.In addition,from the same samples we measured the levels of inflammatory proteins,albumin,orosomukoid,IgA,C-reactive protein.Complex evaluation of inflammatory response and cellular immunity in blood was performed,too.Results:Immediately after application of the first dose we observed significant improvements of clinical conditions which were persistent throughout the entire study.Conclusions:Beta glucan is optimal addition to autovaccines,as it is natural,active,safe and inexpensive.We propose that the possibility to use beta glucans in application of autovaccines is the first step in preparation of qualitative new type of autovaccines against UTI.
