The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death.Recent findings implicate that this pathway is involved in the process of intestinal regenerat...The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death.Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis.Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis,regeneration and tumorigenesis,and the crosstalk between the Hippo signaling pathway and other major signaling pathways,i.e.Wnt,Notch and Jak/Stat signaling pathways in intestinal compartment.展开更多
基金supported by grants from the China’s 1000 Young Talents Program,the 111 Project of The Ministration of Education of China(No.B06016)the Fundamental Research Funds for the Central Universities of China(No.2010111079)+1 种基金National Natural Science Foundation of China(Grant No.81101503)and Natural Science Foundation of Fujian(No.2011J05096)supported by the RO1 awards CA136567(JA),DK17776(JA)and institutional funds.The authors have no financial conflicts to disclose.
文摘The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death.Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis.Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis,regeneration and tumorigenesis,and the crosstalk between the Hippo signaling pathway and other major signaling pathways,i.e.Wnt,Notch and Jak/Stat signaling pathways in intestinal compartment.
