Most eukaryotes have a self-sustaining circadian clock that senses environmental cues and the internal metabolic state and then imposes daily temporal organization of the physiology.The clock,by nature,regulates the d...Most eukaryotes have a self-sustaining circadian clock that senses environmental cues and the internal metabolic state and then imposes daily temporal organization of the physiology.The clock,by nature,regulates the daily creation and destruction of a large quantity of RNA and proteins,including those at the core of the oscillator itself.Although a transcriptional-translational feedback loop maintains the rhythmicity of the oscillator,various post-translational modifications(PTMs)of clock proteins play fundamental roles in keeping the pace of the circadian clock near 24 h.To maintain circadian clock pacing,PTMs act to ensure the rapid,efficient,and precise activation,inactivation,and finally destruction of core clock proteins(Hirano et al.,2016).展开更多
基金supported by the Forest B.H.and Elizabeth D.W.Brown Fund,National Science Foundation(EAGER#1548538 and IOS#1856452)National Institutes of Health(R35 GM128670).
文摘Most eukaryotes have a self-sustaining circadian clock that senses environmental cues and the internal metabolic state and then imposes daily temporal organization of the physiology.The clock,by nature,regulates the daily creation and destruction of a large quantity of RNA and proteins,including those at the core of the oscillator itself.Although a transcriptional-translational feedback loop maintains the rhythmicity of the oscillator,various post-translational modifications(PTMs)of clock proteins play fundamental roles in keeping the pace of the circadian clock near 24 h.To maintain circadian clock pacing,PTMs act to ensure the rapid,efficient,and precise activation,inactivation,and finally destruction of core clock proteins(Hirano et al.,2016).
