Haptoglobin(HP)is a liver glycoprotein that is actively synthesized during in-flammatory and hemolytic processes.It also has pro-oxidant and proinflam-matory properties,which are a function of its genotype.The genetic...Haptoglobin(HP)is a liver glycoprotein that is actively synthesized during in-flammatory and hemolytic processes.It also has pro-oxidant and proinflam-matory properties,which are a function of its genotype.The genetic polymorp-hism of the chains leads to synthesis of three phenotypes/proteins,which are related to the number and type of chains and their molecular weight,namely HP1-1,HP1-2 and HP2-2.Patients with HP2-2 have more vascular complications,while those with HP1-1 have fewer.HP is involved in the worsening of diseases,such as HP2-2 in aggravation of vaso-occlusive crises in sickle cell disease,and worsening of the pathophysiology of other diseases.In contrast,HP1-1 confers better protection against diseases.All of this suggests that further studies should be conducted,including experimental and analytical studies focused on de-monstrating the influence of different HP genotypes on individual clinical and hematological data.This would help in understanding the role played by this genetic polymorphism in the pathophysiology of diseases.展开更多
文摘Haptoglobin(HP)is a liver glycoprotein that is actively synthesized during in-flammatory and hemolytic processes.It also has pro-oxidant and proinflam-matory properties,which are a function of its genotype.The genetic polymorp-hism of the chains leads to synthesis of three phenotypes/proteins,which are related to the number and type of chains and their molecular weight,namely HP1-1,HP1-2 and HP2-2.Patients with HP2-2 have more vascular complications,while those with HP1-1 have fewer.HP is involved in the worsening of diseases,such as HP2-2 in aggravation of vaso-occlusive crises in sickle cell disease,and worsening of the pathophysiology of other diseases.In contrast,HP1-1 confers better protection against diseases.All of this suggests that further studies should be conducted,including experimental and analytical studies focused on de-monstrating the influence of different HP genotypes on individual clinical and hematological data.This would help in understanding the role played by this genetic polymorphism in the pathophysiology of diseases.
