Objective:To assess the effects of sickle cell anemia (SCA)-on the right ventricle (RV). Study design:Echocardiograms of 32 children with SCA were compared with age-matched healthy controls. RV measurements included d...Objective:To assess the effects of sickle cell anemia (SCA)-on the right ventricle (RV). Study design:Echocardiograms of 32 children with SCA were compared with age-matched healthy controls. RV measurements included diastolic area index,fractional area change,free-wall mass index,ejection time corrected for heart rate (ETc),and tricuspid regurgitation(TR) gradient. Results:SCA subjects had elevated RV ETc(mean ±standard deviation,0.369 ±0.030 sec vs 0.351 ±0.022 sec; P < 0.01),diastolic area index (19.9 ±2.4 cm2/m2 vs13.2 ±2.1 cm2/m2; P < 0.01) and free-wall mass index (33.2 ±4.4 g/m2 vs 23.9 ±4.3 g/m2; P < 0.01),whereas RV fractional area change (37 ±8%vs 36 ±4%) was not different from controls. Although RV diastolic area index in SCA paralleled the normal range over time,RV free-wall mass index continued to gradually rise throughout childhood (r = 0.42; P < 0.05). TR gradients>2.5m/sec,consistent with pulmonary hypertension,were found in 5 (16%) of SCA subjects,all older than 9 years.Conclusions:RV preload and systolic function do not worsen during childhood in SCA; however,RV mass index and the prevalence of pulmonary hypertension increase consistent with rising pulmonary vascular resistance.展开更多
文摘Objective:To assess the effects of sickle cell anemia (SCA)-on the right ventricle (RV). Study design:Echocardiograms of 32 children with SCA were compared with age-matched healthy controls. RV measurements included diastolic area index,fractional area change,free-wall mass index,ejection time corrected for heart rate (ETc),and tricuspid regurgitation(TR) gradient. Results:SCA subjects had elevated RV ETc(mean ±standard deviation,0.369 ±0.030 sec vs 0.351 ±0.022 sec; P < 0.01),diastolic area index (19.9 ±2.4 cm2/m2 vs13.2 ±2.1 cm2/m2; P < 0.01) and free-wall mass index (33.2 ±4.4 g/m2 vs 23.9 ±4.3 g/m2; P < 0.01),whereas RV fractional area change (37 ±8%vs 36 ±4%) was not different from controls. Although RV diastolic area index in SCA paralleled the normal range over time,RV free-wall mass index continued to gradually rise throughout childhood (r = 0.42; P < 0.05). TR gradients>2.5m/sec,consistent with pulmonary hypertension,were found in 5 (16%) of SCA subjects,all older than 9 years.Conclusions:RV preload and systolic function do not worsen during childhood in SCA; however,RV mass index and the prevalence of pulmonary hypertension increase consistent with rising pulmonary vascular resistance.
