Objective To explore the candidate genes that play significant roles in the interconnection between abdominal aortic aneurysm(AAA)and type 2 diabetes mellitus(DM).Methods We used the Biomedical Discovery Support Syste...Objective To explore the candidate genes that play significant roles in the interconnection between abdominal aortic aneurysm(AAA)and type 2 diabetes mellitus(DM).Methods We used the Biomedical Discovery Support System(BITOLA)to screen out the candidate intermediate molecular(CIM)"Gene or Gene Product”that are related to AAA and DM.The dataset of GSE13760,GSE7084,GSE57691,GSE47472 were used to analyze the differentially expressed genes(DEGs)of AAA and DM compared to the healthy status.We used the online tool ofVenny 2.1 assisted by manual checking to identify the overlapped DEGs with the CIMs.The Human eFP Browser was applied to examine the tissue specific expression levels of the detected genes in order to recognize strong expressed genes in both human artery and pancreatic tissue.Results There were 86 CIMs suggested by the closed BITOLA system.Among all the DEGs of AAA and DM,8 genes in GSE7084(ISG20,ITGAX,DSTN,CCL5,CCR5,AGTR1,CD19,CD44)and 2 genes in GSE 13760(PSMD12,FAS)were found to be overlapped with the 86 CIMs.By manual checking and comparing with tissuespecific gene data through Human eFP Browser,the gene PSMD12(proteasome 26S subunit,non-ATPase 12)was recognized to be strongly expressed in both the aorta and pancreatic tissue.Conclusion We proposed a hypothesis through text mining that PSMD12 might be involved or potentially involved in the interconnection between AAA and DM,which may provide a new clue for studies on novel therapeutic strategies for the two diseases.展开更多
In recent years,the development of rural e-commerce has been rapid but not balanced,and the upward scale of agricultural products is much smaller than the downward scale of industrial products.In the upward process of...In recent years,the development of rural e-commerce has been rapid but not balanced,and the upward scale of agricultural products is much smaller than the downward scale of industrial products.In the upward process of agricultural products,there are different models of e-commerce with farmers as the main body or cooperatives as the main body.Comparatively speaking,the difficulties in developing e-commerce for agricultural products with farmers as the main body are more prominent,while the development of e-commerce in agricultural products with cooperatives as the main body has more significant advantages.At present,there are still urgent problems to be solved,such as insufficient cold chain logistics facilities,insufficient scale and strength of cooperatives,and lack of systematic planning of local government's support policies for agricultural products.However,generally speaking,the upward trend for agricultural products based on cooperatives will be the mainstream of the development of agricultural electronic commerce in the future.展开更多
In the world,development modes of farmers specialized cooperative economic organizations mainly includes two types:( i) specialized agricultural cooperatives with the United States of America as representative,and( ii...In the world,development modes of farmers specialized cooperative economic organizations mainly includes two types:( i) specialized agricultural cooperatives with the United States of America as representative,and( ii) comprehensive agricultural cooperatives with Japan and South Korea as representative. In comparison,China mainly develops farmers specialized cooperatives which are agricultural production with family as unit and small in land and management scale like agricultural production in Japan. Therefore,in marketing of agricultural products,cooperatives in the United States of America and Japan have successful experience. China may learn such experience in the development of farmers specialized cooperatives.展开更多
Vascular regeneration and patency maintenance,without anticoagulant administration,represent key developmental trends to enhance small-diameter vascular grafts(SDVG)performance.In vivo engineered autologous biotubes h...Vascular regeneration and patency maintenance,without anticoagulant administration,represent key developmental trends to enhance small-diameter vascular grafts(SDVG)performance.In vivo engineered autologous biotubes have emerged as SDVG candidates with pro-regenerative properties.However,mechanical failure coupled with thrombus formation hinder translational prospects of biotubes as SDVGs.Previously fabricated poly(ε-caprolactone)skeleton-reinforced biotubes(PBs)circumvented mechanical issues and achieved vascular regeneration,but orally administered anticoagulants were required.Here,highly efficient and biocompatible functional modifications were introduced to living cells on PB lumens.The 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(DMPE)-PEG-conjugated anti-coagulant bivalirudin(DPB)and DMPE-PEG-conjugated endothelial progenitor cell(EPC)-binding TPS-peptide(DPT)modifications possessed functionality conducive to promoting vascular graft patency.Co-modification of DPB and DPT swiftly attained luminal saturation without influencing cell viability.DPB repellent of non-specific proteins,DPB inhibition of thrombus formation,and DPB protection against functional masking of DPT’s EPC-capture by blood components,which promoted patency and rapid endothelialization in rat and canine artery implantation models without anticoagulant administration.This strategy offers a safe,facile,and fast technical approach to convey additional functionalization to living cells within tissue-engineered constructs.展开更多
文摘Objective To explore the candidate genes that play significant roles in the interconnection between abdominal aortic aneurysm(AAA)and type 2 diabetes mellitus(DM).Methods We used the Biomedical Discovery Support System(BITOLA)to screen out the candidate intermediate molecular(CIM)"Gene or Gene Product”that are related to AAA and DM.The dataset of GSE13760,GSE7084,GSE57691,GSE47472 were used to analyze the differentially expressed genes(DEGs)of AAA and DM compared to the healthy status.We used the online tool ofVenny 2.1 assisted by manual checking to identify the overlapped DEGs with the CIMs.The Human eFP Browser was applied to examine the tissue specific expression levels of the detected genes in order to recognize strong expressed genes in both human artery and pancreatic tissue.Results There were 86 CIMs suggested by the closed BITOLA system.Among all the DEGs of AAA and DM,8 genes in GSE7084(ISG20,ITGAX,DSTN,CCL5,CCR5,AGTR1,CD19,CD44)and 2 genes in GSE 13760(PSMD12,FAS)were found to be overlapped with the 86 CIMs.By manual checking and comparing with tissuespecific gene data through Human eFP Browser,the gene PSMD12(proteasome 26S subunit,non-ATPase 12)was recognized to be strongly expressed in both the aorta and pancreatic tissue.Conclusion We proposed a hypothesis through text mining that PSMD12 might be involved or potentially involved in the interconnection between AAA and DM,which may provide a new clue for studies on novel therapeutic strategies for the two diseases.
基金Social Science Foundation of Yangtze University in 2015"Study on the Role of Farmers Professional Cooperatives in the Field of Agricultural Product Circulation"(2015csy007).
文摘In recent years,the development of rural e-commerce has been rapid but not balanced,and the upward scale of agricultural products is much smaller than the downward scale of industrial products.In the upward process of agricultural products,there are different models of e-commerce with farmers as the main body or cooperatives as the main body.Comparatively speaking,the difficulties in developing e-commerce for agricultural products with farmers as the main body are more prominent,while the development of e-commerce in agricultural products with cooperatives as the main body has more significant advantages.At present,there are still urgent problems to be solved,such as insufficient cold chain logistics facilities,insufficient scale and strength of cooperatives,and lack of systematic planning of local government's support policies for agricultural products.However,generally speaking,the upward trend for agricultural products based on cooperatives will be the mainstream of the development of agricultural electronic commerce in the future.
基金Supported by Social Science Foundation of Yangtze University in 2015(2015csy007)
文摘In the world,development modes of farmers specialized cooperative economic organizations mainly includes two types:( i) specialized agricultural cooperatives with the United States of America as representative,and( ii) comprehensive agricultural cooperatives with Japan and South Korea as representative. In comparison,China mainly develops farmers specialized cooperatives which are agricultural production with family as unit and small in land and management scale like agricultural production in Japan. Therefore,in marketing of agricultural products,cooperatives in the United States of America and Japan have successful experience. China may learn such experience in the development of farmers specialized cooperatives.
基金supported by the National Natural Science Foundation of China(NSFC)projects 81921004(D.K.),82127808(D.K.),32222043(K.W.),82250610231(A.C.M.)National Key R&D Program of China 2022YFA1105102(K.W.)+3 种基金Tianjin Natural Science Foundation 20JCYBJC01150(K.W.)Tianjin Natural Science Foundation 18JCZDJC37600(K.W.)NCC Fund NCC2020PY18(K.W.)Tianjin"Project+Team"Key Training Foundation XC202035(K.W.).
文摘Vascular regeneration and patency maintenance,without anticoagulant administration,represent key developmental trends to enhance small-diameter vascular grafts(SDVG)performance.In vivo engineered autologous biotubes have emerged as SDVG candidates with pro-regenerative properties.However,mechanical failure coupled with thrombus formation hinder translational prospects of biotubes as SDVGs.Previously fabricated poly(ε-caprolactone)skeleton-reinforced biotubes(PBs)circumvented mechanical issues and achieved vascular regeneration,but orally administered anticoagulants were required.Here,highly efficient and biocompatible functional modifications were introduced to living cells on PB lumens.The 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(DMPE)-PEG-conjugated anti-coagulant bivalirudin(DPB)and DMPE-PEG-conjugated endothelial progenitor cell(EPC)-binding TPS-peptide(DPT)modifications possessed functionality conducive to promoting vascular graft patency.Co-modification of DPB and DPT swiftly attained luminal saturation without influencing cell viability.DPB repellent of non-specific proteins,DPB inhibition of thrombus formation,and DPB protection against functional masking of DPT’s EPC-capture by blood components,which promoted patency and rapid endothelialization in rat and canine artery implantation models without anticoagulant administration.This strategy offers a safe,facile,and fast technical approach to convey additional functionalization to living cells within tissue-engineered constructs.
