Advancement of Complications Related to Augmentation Mammoplasty using Silicone Gel Prosthesis

Augmentation mammaplasty with implants is a form of plastic surgery that can ameliorate breast volume deficiencies and achieve beautiful breast shape using implants.Complications after augmentation mammoplasty are the main reasons that may hinder its use or result in procedural failure.Here,we review the mechanism,clinical manifestations,and treatment of the main complications,such as capsular contracture,implant malposition,and rippling,of augmentation mammaplasty.We aimed to achieve a more stable,reliable,and long-lasting effect on implant mammoplasty to eventually benefit our patients.

术前免疫炎症指数与胃癌患者预后关系的研究

目的:探讨术前免疫炎症指数(systemic immune-inflammation index,SII)与胃癌患者预后的关系。方法:回顾性分析2010年6月至2015年6月青海大学附属医院收治的接受手术治疗的胃癌患者临床资料,计算其SII数值。相关性分析采用Spearman相关系数。应用受试者工作特征曲线(receiver operating characteristic curve,ROC)确定SII的最佳临界值,χ2检验评价SII与各项临床病理特征之间的关系。Kaplan-Meier法绘制生存曲线,并计算总生存时间(overall survival,OS),显著性分析采用Logrank检验。应用Cox比例风险模型进行预后因素的单因素和多因素分析。结果:共纳入771例患者,其中男性606例、女性165例,年龄25~81(56.91±9.546)岁。Spearmen相关性分析结果显示,SII与胃癌患者术后生存率呈正相关(r=0.399,P<0.001)。ROC曲线确定SII的最佳临界值为489.52,将771例胃癌患者分为低SII(L-SII)组(SII≤489.52)和高SII(H-SII)组(SII>489.52)。Kaplan-Meier分析显示L-SII组胃癌患者生存率明显优于H-SII组,两组总体生存率差异具有统计学意义(P<0.05)。Ⅰ、Ⅱ、Ⅲ期中L-SII组的5年生存率明显高于H-SII组(分别为81.8%vs.24.8%、56.5%vs.21.2%、62.5%vs.24.6%),差异具有统计学意义(P<0.05)。单因素分析显示H-SII是胃癌患者预后的危险因素(HR=3.919,95%CI:3.087~4.977,P<0.001),多因素分析提示术前外周血SII是胃癌患者预后的独立危险因素(HR=2.707,95%CI:2.074~3.533,P<0.001)。再次通过ROC曲线比较SII与其他指标预测胃癌患者预后的能力,显示SII具有更准确的预测能力。将SII联合Alb、CEA、CA125、WBC较单独预测具有更优的预测效能(AUC=0.786)。结论:SII是胃癌患者预后的独立危险因素。术前外周血SII的升高提示着更差的预后。

Cell atlas of CCl_(4)-induced progressive liver fibrosis reveals stage-specific responses

Chronic liver injury leads to progressive liver fibrosis and ultimately cirrhosis,a major cause of morbidity and mortality worldwide.However,there are currently no effective anti-fibrotic therapies available,especially for latestage patients,which is partly attributed to the major knowledge gap regarding liver cell heterogeneity and cellspecific responses in different fibrosis stages.To reveal the multicellular networks regulating mammalian liver fibrosis from mild to severe phenotypes,we generated a single-nucleus transcriptomic atlas encompassing 49919nuclei corresponding to all main liver cell types at different stages of murine carbon tetrachloride(CCl_(4))-induced progressive liver fibrosis.Integrative analysis distinguished the sequential responses to injury of hepatocytes,hepatic stellate cells and endothelial cells.Moreover,we reconstructed the cell-cell interactions and gene regulatory networks implicated in these processes.These integrative analyses uncovered previously overlooked aspects of hepatocyte proliferation exhaustion and disrupted pericentral metabolic functions,dysfunction for clearance by apoptosis of activated hepatic stellate cells,accumulation of pro-fibrotic signals,and the switch from an anti-angiogenic to a pro-angiogenic program during CCl_(4)-induced progressive liver fibrosis.Our dataset thus constitutes a useful resource for understanding the molecular basis of progressive liver fibrosis using a relevant animal model.

An Ion-Pumping Interphase on Graphdiyne/Graphite Heterojunction for Fast-Charging Lithium-Ion Batteries

The sluggish lithium-ion(Li-ion)transport kinetics in graphite anode hinders its application in fast-charging Li-ion batteries(LIBs).Here,we develop an ionpumping interphase(IPI)on graphdiyne(GDY)/graphite heterojunction anodes to boost the ionic transport kinetics and enable high-performance,fast-charging LIBs.The IPI changed the ion solvation/desolvation environment by covalent/non-covalent interactions with Li ions or solvents to optimize solid-electrolyte interphase(SEI)and regulate Li-ion transport behavior.We studied the in situ growth of few-layer GDY on graphite surface(GDY/graphite)as the IPI and found that the strong interaction between GDY and Li ions enabled surface-induced modification of the ion solvation behavior and surface-assisted desolvation effect to accelerate the Li-ion desolvation process.A functional anion-derived SEI layer with improved Li-ion conductivity was created.Together with the generated built-in electric field at GDY/graphite hetero-interface self-pumping Li ions to intercalate into the graphite,the Li-ion transport kinetics was significantly enhanced to effectively eliminate Li plating and large voltage polarization of the graphite anodes.A fast Li intercalation in GDY/graphite without Li oversaturation at the edge of the graphite was directly observed.The superior performance with high capacity(139.2 mA h g^(-1))and long lifespan(1650 cycles)under extremely fast-charging conditions(20 C,1 C=372 mA g^(-1))was achieved on GDY/graphite anodes.Even at low temperatures(-20℃),a specific capacity of 128.4 mA h g^(-1) was achieved with a capacity retention of 80%after 500 cycles at a 2 C rate.

Synthesis techniques, mechanism, and prospects of high-loading single-atom catalysts for oxygen reduction reactions

The importance of the oxygen reduction reaction (ORR) in fuel cells and zinc-air batteries is self-evident, and effective catalysts could significantly improve the catalytic efficiency of ORR. Single-atom catalysts are gaining increasing interest due to their high atom efficiency and effective catalytic performance compared to other catalyst types. While the optimal loading of catalytic sites in single-atom catalysts significantly influences their catalytic efficiency. However, creating stable single-atom catalysts with high-loading remains a difficult task. Therefore, we showcase and describe the latest developments in techniques for producing single-atom catalysts with high-loadings. In addition, the performance of noble metal, non-precious metal, and diatomic catalysts in ORR processes is summarized. What’s more, the key difficulties and opportunities in the sector are demonstrated by examining the synthesis techniques and evaluating the performance and structure. This review will help researchers to advance the research process of high-loading single-atom catalysts and accelerate their practical application in the field of ORR research.

Amplification of the miR-181c/d cluster is inversely correlated with PDCD4 expression in gastric cancer

miR-181c/d is dysregulated in gastric cancer(GC).We investigated the amplification and expression of miR-181c/d and its predicted target genes in GC.Amplification of miR-181c/d was quantified by genomic real-time PCR in GC and adjacent normal tissues,as well as the levels of mature miR-181c/d was performed by real-time PCR in the same tissues.The potential target genes of miR-181c/d were predicted using bioinformatics software.Expression of one potential target gene,PDCD4,was measured by semiquantitative RT-PCR,real-time PCR,and immunohistochemistry.Next,the relationship between miR181c/d expression and PDCD4 expression was analyzed.Results indicated that the amplification and expression of miR-181c/d were significantly higher in GC than in adjacent normal tissues(primary miR-181c/d,P\0.001;miR-181c,P=0.0344;miR-181d,P=0.0153),and there was a strong correlation between mature miR-181c/d and primary miR-181c/d.Thirty-two target genes were predicted,including PDCD4 which is a known tumor suppressor gene.Expression of PDCD4 was significantly down-regulated in GC as compared to adjacent normal tissues and was inversely correlated with miR-181c/d expression in GC(miR-181c and PDCD4:R=-0.496,P=0.008;miR-181d and PDCD4:R=-0.454,P=0.003).Therefore,miR-181c/d may play a pivotal role in the pathogenesis of GC by downregulating PDCD4 expression.