Objective:To summarize the clinical characteristics and treatment outcome of 3 cases of Listeria monocytogenes(Lm)meningitis in immunocompetent children,improve clinicians'awareness of the disease.Methods:The clin...Objective:To summarize the clinical characteristics and treatment outcome of 3 cases of Listeria monocytogenes(Lm)meningitis in immunocompetent children,improve clinicians'awareness of the disease.Methods:The clinical features and treatment of Lm meningitis in children admitted to Children's Hospital of Zhejiang University School of Medicine from January 2016 to May 2019 were analyzed retrospectively.We summarized related literatures,and compared the selection of antibiotics in children with Lm meningitis reported in cases.Results:All patients had fever,vomiting and other symptoms,CSF as purulent meningitis performance,Ampicillin is currently the first choice of treatment,while meropenem and Linezolid could be administered as alternative drugs for Lm meningitis.Conclusions:For children with meningitis,when the empirical antibiotics treatment fill,the possibility of Lm meningitis should be considered,and antibiotics that can effectively cover Lm should be adjusted in time.展开更多
The serrated plastic flow,microstructure and residual stress of a Zr_（55）Cu_（30）Ni_5Al_（10） bulk metallic glass（BMG）undergone surface mechanical attrition treatment（SMAT）have been investigated by a combinati...The serrated plastic flow,microstructure and residual stress of a Zr_（55）Cu_（30）Ni_5Al_（10） bulk metallic glass（BMG）undergone surface mechanical attrition treatment（SMAT）have been investigated by a combination of compression tests with scanning electron microscopy（SEM）,high resolution transmission electron microscopy（HRTEM）and the incremental hole-drilling strain-gage method.It is found that SMAT leads to various microstructural modifications and residual stress distribution in the surface layers of the Zrbased BMG due to the mechanically-induced nanocrystallization and generation of shear bands.As a result,the BMG alloy exhibits a remarkable work-hardening like behavior and significant increase of plastic strain from less than 1%to 15%,and its plastic deformation dynamics yields a power-law distribution of shear avalanches.Based upon the analysis of the experimental results,it is indicated that this can be connected to the SMAT-induced microstructural modifications and the resulting residual compressive stress in the Zr-based BMG.展开更多
基金Natural Science Foundation of Zhejiang Province(No.LY15H080003)
文摘Objective:To summarize the clinical characteristics and treatment outcome of 3 cases of Listeria monocytogenes(Lm)meningitis in immunocompetent children,improve clinicians'awareness of the disease.Methods:The clinical features and treatment of Lm meningitis in children admitted to Children's Hospital of Zhejiang University School of Medicine from January 2016 to May 2019 were analyzed retrospectively.We summarized related literatures,and compared the selection of antibiotics in children with Lm meningitis reported in cases.Results:All patients had fever,vomiting and other symptoms,CSF as purulent meningitis performance,Ampicillin is currently the first choice of treatment,while meropenem and Linezolid could be administered as alternative drugs for Lm meningitis.Conclusions:For children with meningitis,when the empirical antibiotics treatment fill,the possibility of Lm meningitis should be considered,and antibiotics that can effectively cover Lm should be adjusted in time.
基金the financial supports provided by National Natural Science Foundation of China(Grant Nos.51171099,50871063)the MOST 973 Program of China(Grant Nos.2015CB856800 and 2012CB932203)
文摘The serrated plastic flow,microstructure and residual stress of a Zr_（55）Cu_（30）Ni_5Al_（10） bulk metallic glass（BMG）undergone surface mechanical attrition treatment（SMAT）have been investigated by a combination of compression tests with scanning electron microscopy（SEM）,high resolution transmission electron microscopy（HRTEM）and the incremental hole-drilling strain-gage method.It is found that SMAT leads to various microstructural modifications and residual stress distribution in the surface layers of the Zrbased BMG due to the mechanically-induced nanocrystallization and generation of shear bands.As a result,the BMG alloy exhibits a remarkable work-hardening like behavior and significant increase of plastic strain from less than 1%to 15%,and its plastic deformation dynamics yields a power-law distribution of shear avalanches.Based upon the analysis of the experimental results,it is indicated that this can be connected to the SMAT-induced microstructural modifications and the resulting residual compressive stress in the Zr-based BMG.
