2010-2019年甘肃省肿瘤登记地区肺癌发病的流行病学特征分析

背景与目的肺癌是中国发病率最高、疾病负担最重的恶性肿瘤。近年来,肺癌呈高发趋势,严重影响人群健康。本文通过分析甘肃省肿瘤登记地区2019年肺癌发病特征及2010-2019年发病率趋势,为甘肃省肺癌防控策略制定提供参考依据。方法通过分析甘肃省肿瘤登记地区2019年肺癌发病个案,计算发病率、中标发病率、世标发病率等相关指标;采用Joinpoint计算年度变化百分比(annual percent change,APC),进行趋势分析。结果2019年甘肃省共报告肺癌新发病例3757例,占所有新发恶性肿瘤的14.96%,肺癌发病率、中标率、世标率分别为40.52/10万、30.91/10万和25.86/10万,0-74岁累积率、35-64岁截缩率分别为3.23%和40.03/10万。肺癌发病随着年龄增长而上升,在≥40岁组高发,男、女性人群分别在≥75岁组、≥80岁组达到发病高峰。2010-2019年甘肃省肿瘤登记地区肺癌粗发病率总体呈上升趋势,且上升速度较快,APC为5.39%(P<0.05);分别按照性别、城乡进行统计,各人群肺癌发病率均呈上升趋势,男性、女性、城市、农村人群APC分别为4.98%、6.39%、6.26%和4.64%(P均<0.05)。按照年龄组肺癌发病率进行趋势分析,仅≥65岁组人群肺癌发病以年均4.15%的速度上升(P<0.05)。结论2010-2019年甘肃省肿瘤登记地区肺癌发病率呈现逐年上升趋势,不同性别、地区及年龄组人群肺癌发病存在差异,应针对肺癌发病重点人群开展综合防控工作。

Monophyly and infrageneric variation of Corispermum L.(Chenopodiaceae),evidence from sequence data psbB-psbH,rbcL and ITS

Corispermum is one of the most problematic taxonomic genera in Chenopodiaceae.To understand the phylogeny and infrageneric variation of Corispermum,we sequenced the nuclear ribosomal ITS region and two chloroplast DNA regions(rbcL and psbB-psbH) of 22 species and three varieties of Corispermum and the related genus Agriophyllum.Several representative species of Salsola,Suaeda,Chenopodium,Kalidium and Camphorosma served as outgroups.Our phylogenetic trees confirm that the tribe Corispermeae is monophyletic,Corispermum and Agriophyllum have a close relationship.Corispermum is demonstrated to be monophyletic,and contains at least four clades which,consequently,are served as the foundation of the infrageneric sectional variation of Corispermum,in terms of a combination of molecular data and morphological characters.The evolution of morphological characters for fruit wing and apex,two important characters in generic classification,is consistent with the sectional division of Corispermum,especially to the East Asian and Chinese taxa.

Energy transfer, anticounterfeiting, white light emission and sensing in fine-regulating series of lanthanide metal-organic frameworks

Three lanthanide ions and a rigid(1,1'-biphenyl)-2,4,6-tricarboxylic acid(H_(3)bptc) ligand led to the isostructural lanthanide metal-organic frameworks(Ln-MOFs) {[Ln(bptc)(H_(2)O)_(3)]·3H_(2)O}_n(Lnbptc, Ln = Eu,Tb, Gd, Eu_(x)Tb_(1—x), Eu_(x)Gd_(1-x), Tb_(x)Gd_(1-x), and Eu_(0.12)Tb_(0.52)Gd_(0.36)). The density functional theory(DFT) and time-dependent DFT calculation were expanded on H_3bptc, which point to the occurrence of “antenna effect”. The minor diameter samples of Eubptc, Tbbptc, and Gdbptc can also be attained via the microwave synthesis and employed for handwriting anticounterfeiting. Interestingly, the typical red emission of Eu^(3+) and green emission of Tb~(3+) could be fine-tuned by Gd^(3+) via chemical mixing to be full-color emissions bimetallic doped Eu_(x)Tb_(1-x)bptc, Eu_(x)Gd_(1-x)bptc, and Tb_(x)Gd_(1-x)bptc. The above synthetic bimetallic MOFs can be fixed in positioning boxes of quick response(QR) codes with diverse emission for anticounterfeiting. The message can be decoded under the irradiation of 365 nm ultraviolet lamp while invisible in the daylight. Notably, the trimetallic doped Eu_(0.12)Tb_(0.52)Gd_(0.36)bptc emits white light with the CIE color coordinate(0.34, 0.34). Furthermore, Tbbptc is demonstrated to be a sensitive probe toward nitrobenzene and acetone with multiple mechanisms.

Impact of Cold Spells on Ischemic Stroke Severity and Clinical Outcomes in Tianjin, China

There are several studies on the impact of extreme weather on the incidence and mortality of stroke, but the research on the effect of extreme weather events on severity and outcome of ischemic stroke is scarce. This study aimed to evaluate the impact of cold spells on the severity and clinical outcomes of patients with initial acute ischemic stroke in a hospital-based study. We enrolled 553 patients with initial ischemic stroke during the cold seasons between 2016 and 2019. Patients were separated into the mild stroke group and moderate-to-severe stroke group according to the National Institutes of Health Stroke Scale(NIHSS) of the U.S., and good outcome group and poor outcome group according to modified Rankin Scale(mRS) scores. There are nine different definitions of cold spells according to intensities and duration time. After adjustment for climate factors, air quality index, and common risk factors, it is found that cold spells were associated with moderate-to-severe neurological deficits and clinical outcomes in overall ischemic stroke patients. Furthermore, the delay effect for stroke severity started at the beginning of the cold wave(Lag 0) and lasted up to 14 days(Lags 0–14). In addition, when a cold spell was set as a daily mean temperature < 3rd or 5th percentile and with a duration ≥ 2 or 3 consecutive days, cold spells had a significant impact on clinical outcomes, and there was a definite delay effect of at least 7 days(Lags 0–7) and it lasted up to 14days(Lags 0–14). At last, we concluded that cold spells may be a contributory factor for more severe neurological deficits and worse outcomes in patients with initial ischemic stroke.