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STAT5 promotes PD-L1 expression by facilitating histone lactylation to drive immunosuppression in acute myeloid leukemia 被引量:2
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作者 Ze-Wei Huang xue-Ning Zhang +6 位作者 Ling Zhang Ling-Ling Liu Jing-Wen Zhang Yu-Xiang Sun jue-qiong xu Quentin Liu Zi-Jie Long 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2023年第10期5106-5118,共13页
Immunotherapy is a revolutionized therapeutic strategy for tumor treatment attributing to the rapid development of genomics and immunology,and immune checkpoint inhibitors have successfully achieved responses in numbe... Immunotherapy is a revolutionized therapeutic strategy for tumor treatment attributing to the rapid development of genomics and immunology,and immune checkpoint inhibitors have successfully achieved responses in numbers of tumor types,including hematopoietic malignancy.However,acute myeloid leukemia(AML)is a heterogeneous disease and there is stll a lack of systematic demonstration to apply immunotherapy in AML based on PD-1/PD-L1 blockage. 展开更多
关键词 MYELOID acute LEUKEMIA
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