Purpose Whether elite athletes,who have been exposed to vigorous-intensity exercise combined with other stressors,have elevated systemic low-grade inflammation,remains largely unclear.To address this question,we studi...Purpose Whether elite athletes,who have been exposed to vigorous-intensity exercise combined with other stressors,have elevated systemic low-grade inflammation,remains largely unclear.To address this question,we studied the levels of six inflammatory cytokines as potential biomarkers of a low-grade inflammatory state in elite athletes after an 11-month train-ing and competition season.Methods We collected sera from 27 Finnish elite cross-country skiers and 27 gender-and age-matched,moderately-exer-cising controls.The serum concentrations of C-reactive protein(CRP),interleukin 6(IL-6),tumor necrosis factor alpha(TNF-α),glycoprotein acetyls(GlycA),interleukin 10(IL-10),and interferon gamma(IFN-γ)cytokines were quantified as surrogate markers of low-grade inflammation.Results The athletes were found to have significantly lower concentrations of CRP(P=0.0232)and higher concentrations of IL-10,TNF-α,and IFN-γ(P=0.0097,P=0.0256,and P=0.0185,respectively)than the controls.No significant differences between athletes and controls were detected in the concentrations of IL-6 and GlycA.The inflammatory score(IS)did not differ significantly between athletes and controls.Conclusion The results of this study argued against the hypothesis of a significant chronic low-grade inflammation in response to prolonged high-performance exercise among elite endurance athletes.展开更多
基金Open Access funding provided by University of Turku(UTU)including Turku University Central Hospital.Jenny and Antti Wihuri Foundation.
文摘Purpose Whether elite athletes,who have been exposed to vigorous-intensity exercise combined with other stressors,have elevated systemic low-grade inflammation,remains largely unclear.To address this question,we studied the levels of six inflammatory cytokines as potential biomarkers of a low-grade inflammatory state in elite athletes after an 11-month train-ing and competition season.Methods We collected sera from 27 Finnish elite cross-country skiers and 27 gender-and age-matched,moderately-exer-cising controls.The serum concentrations of C-reactive protein(CRP),interleukin 6(IL-6),tumor necrosis factor alpha(TNF-α),glycoprotein acetyls(GlycA),interleukin 10(IL-10),and interferon gamma(IFN-γ)cytokines were quantified as surrogate markers of low-grade inflammation.Results The athletes were found to have significantly lower concentrations of CRP(P=0.0232)and higher concentrations of IL-10,TNF-α,and IFN-γ(P=0.0097,P=0.0256,and P=0.0185,respectively)than the controls.No significant differences between athletes and controls were detected in the concentrations of IL-6 and GlycA.The inflammatory score(IS)did not differ significantly between athletes and controls.Conclusion The results of this study argued against the hypothesis of a significant chronic low-grade inflammation in response to prolonged high-performance exercise among elite endurance athletes.
