Antibody-platinum(IV)prodrugs conjugates for targeted treatment of cutaneous squamous cell carcinoma

Antibody-drug conjugates(ADCs)are a new type of targeting antibodies that conjugate with highly toxic anticancer drugs via chemical linkers to exert high specificity and efficient killing of tumor cells,thereby attracting considerable attention in precise oncology therapy.Cetuximab(Cet)is a typical antibody that offers the benefits of good targeting and safety for individuals with advanced and inoperable cutaneous squamous cell carcinoma(cSCC);however,its anti-tumor activity is limited to a single use.Cisplatin(CisPt)shows good curative effects;however,its adverse effects and non-tumor-targeting ability are major drawbacks.In this study,we designed and developed a new ADC based on a new cytotoxic platinum(IV)prodrug(C8Pt(IV))and Cet.The so-called antibody-platinum(IV)prodrugs conjugates,named Cet-C8Pt(IV),showed excellent tumor targeting in cSCC.Specifically,it accurately delivered C8Pt(IV)into tumor cells to exert the combined anti-tumor effect of Cet and CisPt.Herein,metabolomic analysis showed that Cet-C8Pt(IV)promoted cellular apoptosis and increased DNA damage in cSCC cells by affecting the vitamin B6 metabolic pathway in tumor cells,thereby further enhancing the tumor-killing ability and providing a new strategy for clinical cancer treatment using antibody-platinum(IV)prodrugs conjugates.

New advances of adiponectin in regulating obesity and related metabolic syndromes

Obesity and related metabolic syndromes have been recognized as important disease risks,in which the role of adipokines cannot be ignored.Adiponectin(ADP)is one of the key adipokines with various beneficial effects,including improving glucose and lipid metabolism,enhancing insulin sensitivity,reducing oxidative stress and inflammation,promoting ceramides degradation,and stimulating adipose tissue vascularity.Based on those,it can serve as a positive regulator in many metabolic syndromes,such as type 2 diabetes(T2D),cardiovascular diseases,non-alcoholic fatty liver disease(NAFLD),sarcopenia,neurodegenerative diseases,and certain cancers.Therefore,a promising therapeutic approach for treating various metabolic diseases may involve elevating ADP levels or activating ADP receptors.The modulation of ADP genes,multimerization,and secretion covers the main processes of ADP generation,providing a comprehensive orientation for the development of more appropriate therapeutic strategies.In order to have a deeper understanding of ADP,this paper will provide an all-encompassing review of ADP.

Association between inflammatory bowel disease and all-cause dementia:A two-sample Mendelian randomization study

BACKGROUND Numerous observational studies have documented a correlation between inflammatory bowel disease(IBD)and an increased risk of dementia.However,the causality of their associations remains elusive.AIM To assess the causal relationship between IBD and the occurrence of all-cause dementia using the two-sample Mendelian randomization(MR)method.METHODS Genetic variants extracted from the large genome-wide association study(GWAS)for IBD(the International IBD Genetics Consortium,n=34652)were used to identify the causal link between IBD and dementia(FinnGen,n=306102).The results of the study were validated via another IBD GWAS(United Kingdom Biobank,n=463372).Moreover,MR egger intercept,MR pleiotropy residual sum and outlier,and Cochran's Q test were employed to evaluate pleiotropy and heterogeneity.Finally,multiple MR methods were performed to estimate the effects of genetically predicted IBD on dementia,with the inverse variance weighted approach adopted as the primary analysis.RESULTS The results of the pleiotropy and heterogeneity tests revealed an absence of significant pleiotropic effects or heterogeneity across all genetic variants in outcome GWAS.No evidence of a causal effect between IBD and the risk of dementia was identified in the inverse variance weighted[odds ratio(OR)=0.980,95%CI:0.942-1.020,P value=0.325],weighted median(OR=0.964,95%CI:0.914-1.017,P value=0.180),and MR-Egger(OR=0.963,95%CI:0.867-1.070,P value=0.492)approaches.Consistent results were observed in validation analyses.Reverse MR analysis also showed no effect of dementia on the development of IBD.Furthermore,MR analysis suggested that IBD and its subtypes did not causally affect allcause dementia and its four subtypes,including dementia in Alzheimer's disease,vascular dementia,dementia in other diseases classified elsewhere,and unspecified dementia.CONCLUSION Taken together,our MR study signaled that IBD and its subentities were not genetically associated with all-cause dementia or its subtypes.Further large prospective studies are warranted to elucidate the impact of intestinal inflammation on the development of dementia.

Prediction model for hepatitis B e antigen seroconversion in chronic hepatitis B with peginterferon-alfa treated based on a responseguided therapy strategy

BACKGROUND Models for predicting hepatitis B e antigen(HBeAg)seroconversion in patients with HBeAg-positive chronic hepatitis B(CHB)after nucleos(t)ide analog treatment are rare.AIM To establish a simple scoring model based on a response-guided therapy(RGT)strategy for predicting HBeAg seroconversion and hepatitis B surface antigen(HBsAg)clearance.METHODS In this study,75 previously treated patients with HBeAg-positive CHB underwent a 52-week peginterferon-alfa(PEG-IFNα)treatment and a 24-wk follow-up.Logistic regression analysis was used to assess parameters at baseline,week 12,and week 24 to predict HBeAg seroconversion at 24 wk post-treatment.The two best predictors at each time point were used to establish a prediction model for PEG-IFNαtherapy efficacy.Parameters at each time point that met the corresponding optimal cutoff thresholds were scored as 1 or 0.RESULTS The two most meaningful predictors were HBsAg≤1000 IU/mL and HBeAg≤3 S/CO at baseline,HBsAg≤600 IU/mL and HBeAg≤3 S/CO at week 12,and HBsAg≤300 IU/mL and HBeAg≤2 S/CO at week 24.With a total score of 0 vs 2 at baseline,week 12,and week 24,the response rates were 23.8%,15.2%,and 11.1%vs 81.8%,80.0%,and 82.4%,respectively,and the HBsAg clearance rates were 2.4%,3.0%,and 0.0%,vs 54.5%,40.0%,and 41.2%,respectively.CONCLUSION We successfully established a predictive model and diagnosis-treatment process using the RGT strategy to predict HBeAg and HBsAg seroconversion in patients with HBeAg-positive CHB undergoing PEG-IFNαtherapy.

Clinical Observation of 48 Cases of Black Eye Circle Treated with Modified Yu Rong San Gel Eye Mask

Objective:To observe the clinical effect of modified Yu Rong San gel eye mask in the treatment of dark circles.Methods:96 cases of patients with dark circles were randomly divided into treatment group and control group.In the control group and the treatment group,the common eye mask and the modified Yu Rong San gel eye mask were applied to the black circle area respectively.After 15min,water was used to wash the face,the application of the mask for one time a day,four weeks,one course,and three courses were observed.Results:After three courses of treatment,the total effective rate of the treatment group was higher than that of the control group(P<0.05);the area of black eye circles in the treatment group was smaller than that before treatment(P<0.05);compared with the control group,the score of black eye circles was lower than that before treatment,the difference was statistically significant(P<0.05).Conclusions Addition and reduction of Yu Rong San gel eye mask is effective in the treatment of dark circles.

丝素蛋白水凝胶在骨关节炎中的应用研究

随着人口老龄化程度的加剧,骨关节炎患者逐年增多,对人类健康形成了严重威胁。然而,到目前为止,对骨关节炎还缺乏令人满意的临床治疗方法。丝素蛋白是一种天然高分子材料,具有良好的生物相容性、生物可降解性和优良的机械性能等特点,被广泛应用于骨组织工程领域。近年来,随着对丝素蛋白研究的不断深入,越来越多的学者开始尝试以丝素蛋白水凝胶为载体治疗骨关节炎,结果表明,其在骨关节炎的治疗中具有巨大的应用潜能。本文总结了迄今为止关于骨关节炎发病机制、常用药物以及丝素蛋白水凝胶治疗骨关节炎的研究进展,为进一步探索应用丝素蛋白水凝胶治疗骨关节炎奠定了基础。

Neutrosophic Adaptive Clustering Optimization in Genetic Algorithm and Its Application in Cubic Assignment Problem

In optimization theory,the adaptive control of the optimization process is an important goal that people pursue.To solve this problem,this study introduces the idea of neutrosophic decision-making into classical heuristic algorithm,and proposes a novel neutrosophic adaptive clustering optimization thought,which is applied in a novel neutrosophic genetic algorithm(NGA),for example.The main feature of NGA is that the NGA treats the crossover effect as a neutrosophic fuzzy set,the variation ratio as a structural parameter,the crossover effect as a benefit parameter and the variation effect as a cost parameter,and then a neutrosophic fitness function value is created.Finally,a high order assignment problem in warehousemanagement is taken to illustrate the effectiveness of NGA.

深度学习在无人船中的应用与挑战

Autonomous surface ships have become increasingly interesting for commercial maritime sectors.Before deep learning(DL)was proposed,surface ship autonomy was mostly model-based.The development of artificial intelligence(AI)has prompted new challenges in the maritime industry.A detailed literature study and examination of DL applications in autonomous surface ships are still missing.Thus,this article reviews the current progress and applications of DL in the field of ship autonomy.The history of different DL methods and their application in autonomous surface ships is briefly outlined.Then,the previously published works studying DL methods in ship autonomy have been categorized into four groups,i.e.,control systems,ship navigation,monitoring system,and transportation and logistics.The state-of-the-art of this review paper majorly lies in presenting the existing limitations and innovations of different applications.Subsequently,the current issues and challenges for DL application in autonomous surface ships are discussed.In addition,we have proposed a comparative study of traditional and DL algorithms in ship autonomy and also provided the future research scope as well.

Developments and Applications of Neutrosophic Theory in Civil Engineering Fields:A Review

Neutrosophic theory can effectively and reasonably express indeterminate,inconsistent,and incomplete information.Since Smarandache proposed the neutrosophic theory in 1998,neutrosophic theory and related research have been developed and applied to many important fields.Indeterminacy and fuzziness are one of the main research issues in the field of civil engineering.Therefore,the neutrosophic theory is very suitable for modeling and applications of civil engineering fields.This review paper mainly describes the recent developments and applications of neutrosophic theory in four important research areas of civil engineering:the neutrosophic decision-making theory and applied methods,the neutrosophic evaluation methods and applications of slope stability,the neutrosophic expressions and analyses of rock joint roughness coefficient,and the neutrosophic structural optimization methods and applications.In terms of these research achievements in the four areas of civil engineering,the neutrosophic theory demonstrates its advantages in dealing with the indeterminate and inconsistent issues in civil engineering and the effectiveness and practicability of existing applied methods.In the future work,the existing research results will be further improved and extended in civil engineering problems.In addition,the neutrosophic theory will also have better application prospects in other fields of civil engineering.

Novel Distance Measures on Hesitant Fuzzy Sets Based on Equal-Probability Transformation and Their Application in Decision Making on Intersection Traffic Control

The purpose of this study is to reduce the uncertainty in the calculation process on hesitant fuzzy sets(HFSs).The innovation of this study is to unify the cardinal numbers of hesitant fuzzy elements(HFEs)in a special way.Firstly,a probability density function is assigned for any given HFE.Thereafter,equal-probability transformation is introduced to transform HFEs with different cardinal numbers on the condition into the same probability density function.The characteristic of this transformation is that the higher the consistency of the membership degrees in HFEs,the higher the credibility of the mentioned membership degrees is,then,the bigger the probability density values for them are.According to this transformation technique,a set of novel distance measures on HFSs is provided.Finally,an illustrative example of intersection traffic control is introduced to show the usefulness of the given distance measures.The example also shows that this study is a good complement to operation theories on HFSs.

License Plate Recognition via Attention Mechanism

License plate recognition technology use widely in intelligent trafficmanagement and control. Researchers have been committed to improving thespeed and accuracy of license plate recognition for nearly 30 years. This paperis the first to propose combining the attention mechanism with YOLO-v5and LPRnet to construct a new license plate recognition model (LPR-CBAMNet).Through the attention mechanism CBAM(Convolutional Block AttentionModule), the importance of different feature channels in license platerecognition can be re-calibrated to obtain proper attention to features. Forceinformation to achieve the purpose of improving recognition speed andaccuracy. Experimental results show that the model construction methodis superior in speed and accuracy to traditional license plate recognitionalgorithms. The accuracy of the recognition model of the CBAM model isincreased by two percentage points to 97.2%, and the size of the constructedmodel is only 1.8 M, which can meet the requirements of real-time executionof embedded low-power devices. The codes for training and evaluating LPRCBAM-Net are available under the open-source MIT License at: https://github.com/To2rk/LPR-CBAM-Net.

从“以苏为师”到“以苏为鉴”:百年中国共产党新闻理论的历史考察

中国共产党自诞生之日起,就高度重视新闻工作,在马克思列宁主义新闻思想指导下,不断发展新闻事业并逐渐形成了中国共产党的新闻理论体系。从中共早期运用马克思列宁主义指导新闻工作,到新中国成立之初全面学习苏联新闻工作经验,再到积极推进中国新闻改革,中共新闻理论与苏联新闻工作经验之间既关系密切又悄然发生着变化。在中国共产党新闻理论的发展进程中,学习苏联新闻工作经验有其必要性和重要性,但在学习苏联的过程中也一定要与中国各个时期的党情、国情、社情相结合,不能照搬照抄。在推动马克思主义新闻观创新发展和构建中国特色新闻学之际,有必要对百年中国共产党新闻理论变迁中的苏联因素进行全面考察。

Effects of water salinity and N application rate on water- and N-use efficiency of cotton under drip irrigation

In arid and semi-arid regions, freshwater scarcity and high water salinity are serious and chronic problems for crop production and sustainable agriculture development. We conducted a field experiment to evaluate the effect of irrigation water salinity and nitrogen（N） application rate on soil salinity and cotton yield under drip irrigation during the 2011 and 2012 growing seasons. The experimental design was a 3×4 factorial with three irrigation water salinity levels（0.35, 4.61 and 8.04 dS/m） and four N application rates（0, 240, 360 and 480 kg N/hm2）. Results showed that soil water content increased as the salinity of the irrigation water increased, but decreased as the N application rate increased. Soil salinity increased as the salinity of the irrigation water increased. Specifically, soil salinity measured in 1：5 soil：water extracts was 218% higher in the 4.61 dS/m treatment and 347% higher in the 8.04 dS/m treatment than in the 0.35 dS/m treatment. Nitrogen fertilizer application had relatively little effect on soil salinity, increasing salinity by only 3%–9% compared with the unfertilized treatment. Cotton biomass, cotton yield and evapotranspiration（ET） decreased significantly in both years as the salinity of irrigation water increased, and increased as the N application rate increased regardless of irrigation water salinity; however, the positive effects of N application were reduced when the salinity of the irrigation water was 8.04 dS/m. Water use efficiency（WUE） was significantly higher by 11% in the 0.35 dS/m treatment than in the 8.04 dS/m treatment. There was no significant difference in WUE between the 0.35 dS/m treatment and the 4.61 dS/m treatment. The WUE was also significantly affected by the N application rate. The WUE was highest in the 480 kg N/hm2 treatment, being 31% higher than that in the 0 kg N/hm2 treatment and 12% higher than that in the 240 kg N/hm2 treatment. There was no significant difference between the 360 and 480 kg N/hm2 treatments. The N use efficiency（NUE） was significantly lower in the 8.04 dS/m treatment than in either the 4.61 dS/m or the 0.35 dS/m treatment. There was no significant difference in NUE between the latter two treatments. These results suggest that irrigation water with salinity 〈4.61 dS/m does not have an obvious negative effect on cotton production, WUE or NUE under the experimental conditions. Application of N fertilizer（0–360 kg N/hm2） could alleviate salt damage, promote cotton growth, and increase both cotton yield and water use efficiency.

Serum interleukin-34 level can be an indicator of liver fibrosis in patients with chronic hepatitis B virus infection

AIM To investigate whether serum interleukin(IL)-34 levels are correlated with hepatic inflammation and fibrosis in patients with chronic hepatitis B virus(HBV) infection. METHODS In this study, serum IL-34 levels were assessed by enzyme-linked immunosorbent assay in 19 healthy controls and 175 patients with chronic HBV infection undergoing biopsy. The frequently used serological markers of liver fibrosis were based on laboratory indexes measured at the Clinical Laboratory of the Second Affiliated Hospital of Anhui Medical University. Liver stiffness was detected by transient elastography with Fibro Touch. The relationships of non-invasive makers of liver fibrosis and IL-34 levels with inflammation and fibrosis were analyzed. The diagnostic value of IL-34 and other liver fibrosis makers wereevaluated using areas under the receiver operating characteristic curves, sensitivity and specificity.RESULTS Serum IL-34 levels were associated with inflammatory activity in the liver, and IL-34 levels differed among phases of chronic HBV infection(P = 0.001). By comparing serum IL-34 levels among patients with various stages of liver fibrosis determined by liver biopsy, we found that IL-34 levels ≥ 15.83 pg/m L had a high sensitivity of 86.6% and a specificity of 78.7% for identifying severe fibrosis(S3-S4). Furthermore, we showed that IL-34 is superior to the fibrosis-4 score, one of the serum makers of liver fibrosis, in identifying severe liver fibrosis and early cirrhosis in patients with HBV-related liver fibrosis in China.CONCLUSION Our results indicate that IL-34, a cytokine involved in the induction of activation of profibrogenic macrophages, can be an indicator of liver inflammation and fibrosis in patients with chronic HBV infection.

Acute pancreatitis associated with herpes zoster:Case report and literature review

Varicella-zoster virus(VZV)is a type of herpes virus known to cause varicella,mainly in young children,and herpes zoster in adults.Although generally non-lethal,VZV infection can be associated with serious complications,particularly in adults.Acute pancreatitis caused by VZV infection is a rare event,with reports primarily concerning immunocompromised individuals.Here we report a 44-year-old immunocompetent female who developed acute pancreatitis associated with VZV infection.The patient presented with vomiting and persistent pain in the upper quadrant less than one week after diagnosis and treatment for a herpes zoster-related rash with stabbing pain on the abdomen and dorsal right trunk side.A diagnosis of acute pancreatitis was confirmed based on abdominal pain,elevated levels of urine and serum amylase,and findings of peri-pancreatic exudation and effusions by computed tomography and magnetic resonance cholangiopancreatography.This case highlights that,though rare,acute pancreatitis should be considered in VZV patients who complain of abdominal pain,especially in the epigastric area.Early detection and proper treatment are needed to prevent the condition from deteriorating further and to minimize mortality.

Automatic Scallion Seedling Feeding Mechanism with an Asymmetrical High-order Transmission Gear Train

The current automatic scallion-transplanting machine is a complicated mechanism composed of two linkage mechanisms and two band carriers.It delivers seedlings ine ciently because of the movement limitations of the linkage mechanism.This paper proposes a new high-order non-circular gear train for an automatic scallion-seedling feeding mechanism.The proposed gear train has an asymmetrical transmission ratio;i.e.,its transmission ratio varies.This allows the mechanism’s execution component to move in a long displacement and rotate in a large rotation angle.The long displacement enables the execution component to reach the designed working position,and the large rotation angle allows it to feed a scallion in the required pose.A mathematical model for calculating the asymmetrical transmission ratio was established according to the closure requirements and the full-cycle motion of the driven gear pitch curve.Then,the parameter-design model of the new seedling-feeding mechanism was established,based on precise pose points and trajectory-shape control points.Moreover,an aided-design program was developed to obtain the parameter-solution domain of the scallion-seedling feeding mechanism.The mechanism parameters,which met the seedling-feeding function,were optimized to determine the transmission ratio,using a program and a kinematic simulation.Finally,a prototype of the mechanism was produced,and a seedling-feeding experiment was carried out.One-thousand seedlings were tested at a rate of 100 seedlings per minute,and the statistical success rate was 93.4%.Thus,the automatic scallion-seedling feeding mechanism significantly improves the e ciency of automatically transplanting scallions.

Association between TLR7 copy number variations and hepatitis B virus infection outcome in Chinese

AIM To explore whether copy number variations (CNVs) of toll-like receptor 7 (TLR7) are associated with susceptibility to chronic hepatitis B virus (HBV) infection. METHODS This study included 623 patients (495 males and 128 females) with chronic hepatitis B virus infection (CHB) and 300 patients (135 females and 165 males) with acute hepatitis B virus infection (AHB) as controls. All CHB patients were further categorized according to disease progression after HBV infection (CHB, liver cirrhosis, or hepatocellular carcinoma). Copy numbers of the TLR7 gene were measured using the AccuCopy method chi(2) tests were used to evaluate the association between TLR7 CNVs and infection type. P values, odds ratios, and 95% confidence intervals (CIs) were used to estimate the effects of risk. RESULTS Among male patients, there were significant differences between the AHB group and CHB group in the distribution of TLR7 CNVs. Low copy numberof TLR7 was significantly associated with chronic HBV infection (OR = 0.329, 95% CI: 0.229-0.473, P > 0.001). Difference in TLR7 copy number was also found between AHB and CHB female patients, with low copy number again associated with an increased risk of chronic HBV infection (OR = 0.292, 95% CI: 0.173- 0.492, P < 0.001). However, there were no significant differences in TLR7 copy number among the three types of chronic HBV infection (CHB, liver cirrhosis, or hepatocellular carcinoma). In addition, there was no association between TLR7 copy number and titer of the HBV e antigen. CONCLUSION Low TLR7 copy number is a risk factor for chronic HBV infection but is not associated with later stages of disease progression.

Tumor-targeting intravenous lipid emulsion of paclitaxel:Characteristics,stability,toxicity,and toxicokinetics

Lipid nanoemulsions are promising nanodrug delivery carriers that can improve the efficacy and safety of paclitaxel(PTX).However,no intravenous lipid emulsion of PTX has been approved for clinical treatment,and systemic safety profiles have not yet been reported.Here we outline the development of a PTXloaded tumor-targeting intravenous lipid emulsion(PTX Emul)and describe its characteristics,colloidal stability,and systemic safety profiles in terms of acute toxicity,long-term toxicity,and toxicokinetics.We also compare PTX Emul with conventional PTX injection.Results showed that PTX Emul exhibited an ideal average particle size(approximately 160 nm)with narrow size distribution and robust colloidal stability under different conditions.Hypersensitivity reaction and hemolysis tests revealed that PTX Emul did not induce hypersensitivity reactions and had no hemolytic potential.In addition,where the alleviated systemic toxicity of PTX Emul may be attributed to the altered toxicokinetic characteristics in beagle dogs,including the decreased AUC and increased plasma clearance and volume of distribution,PTX Emul alleviated acute and long-term toxicity as evidenced by the enhanced the median lethal dose and approximate lethal dose,moderate body weight change,decreased bone marrow suppression and organ toxicity compared with those under PTX injection at the same dose.A fundamental understanding of the systemic safety profiles,high tumor-targeting efficiency,and superior antitumor activity in vivo of PTX Emul can provide powerful evidence of its therapeutic potential as a future treatment for breast cancer.

Weighted Parameterized Correlation Coefficients of Indeterminacy Fuzzy Multisets and Their Multicriteria Group Decision Making Method with Different Decision Risks

Real-life data introduce noise,uncertainty,and imprecision to statistical projects;it is advantageous to consider strategies to overcome these information expressions and processing problems.Neutrosophic(indeterminate)numbers can flexibly and conveniently represent the hybrid information of the partial determinacy and partial indeterminacy in an indeterminate setting,while a fuzzy multiset is a vital mathematical tool in the expression and processing of multi-valued fuzzy information with different and/or same fuzzy values.If neutrosophic numbers are introduced into fuzzy sequences in a fuzzy multiset,the introduced neutrosophic number sequences can be constructed as the neutrosophic number multiset or indeterminate fuzzy multiset.Motivated based on the idea,this study first proposes an indeterminate fuzzy multiset,where each element in a universe set can be repeated more than once with the different and/or identical indeterminate membership values.Then,we propose the parameterized correlation coefficients of indeterminate fuzzy multisets based on the de-neutrosophication of transforming indeterminate fuzzy multisets into the parameterized fuzzy multisets by a parameter(the parameterized de-neutrosophication method).Since indeterminate decision-making issues need to be handled by an indeterminate decision-making method,a group decision-making method using the weighted parameterized correlation coefficients of indeterminate fuzzy multisets is developed along with decision makers’different decision risks(small,moderate,and large risks)so as to handle multicriteria group decision-making problems in indeterminate fuzzy multiset setting.Finally,the developed group decision-making approach is used in an example on a selection problem of slope design schemes for an open-pit mine to demonstrate its usability and flexibility in the indeterminate group decision-making problem with indeterminate fuzzy multisets.

High-power linearly-polarized tunable Raman fiber laser

In this study, we demonstrate an all-fiber high-power linearly-polarized tunable Raman fiber laser system. An in- house high-power tunable fiber laser was employed as the pump source. A fiber loop mirror （FLM） serving as a high reflectivity mirror and a flat-cut endface serving as an output coupler were adopted to provide broadband feedback. A piece of 59-m commercial passive fiber was used as the Raman gain medium. The Raman laser had a 27.6 nm tuning range from 1112 nm to 1139.6 nm and a maximum output power of 125.3 W, which corresponds to a conversion efficiency of 79.4%. The polarization extinction ratio （PER） at all operational wavelengths was measured to be over 21 dB. To the best of our knowledge, this is the first report on a hundred-watt level linearly-polarized tunable Raman fiber laser.