Background:Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life.Clinically,options for monitoring are often limited,potentially missing subtle neurological changes.Integrin β 1 (ITGB1) and β 3 ...Background:Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life.Clinically,options for monitoring are often limited,potentially missing subtle neurological changes.Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors,which regulate the formation and stability of blood vessels.This study explored the relationship between the expression of ITGB1 and ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance.Methods:The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis,respectively.Results:Furthermore,the results demonstrated that ITGB1 was expressed in ICH tissues,but ITGB3 was not expressed in ICH tissues.Conclusions:In summary,the clinical progression of ICH was related to the expression of ITGB1.ITGB1 may be a potential biomarker and contribute to the treatment of ICH.展开更多
基金supported by the Beijing-Tianjin-Hebei Collaborative innovation community construction project(No.18247788D)。
文摘Background:Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life.Clinically,options for monitoring are often limited,potentially missing subtle neurological changes.Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors,which regulate the formation and stability of blood vessels.This study explored the relationship between the expression of ITGB1 and ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance.Methods:The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis,respectively.Results:Furthermore,the results demonstrated that ITGB1 was expressed in ICH tissues,but ITGB3 was not expressed in ICH tissues.Conclusions:In summary,the clinical progression of ICH was related to the expression of ITGB1.ITGB1 may be a potential biomarker and contribute to the treatment of ICH.
