The effect of temperature-responsive solution behavior of PNIPAM-b-PPEOMA-b-PNIPAM on its inclusion complexation with α-cyclodextrin was studied. The triblock polymer was prepared by reversible addition-fragmentation...The effect of temperature-responsive solution behavior of PNIPAM-b-PPEOMA-b-PNIPAM on its inclusion complexation with α-cyclodextrin was studied. The triblock polymer was prepared by reversible addition-fragmentation chain transfer （RAFT） polymerization and formed inclusion complexes （ICs） after selective threading of the PEO segment of the triblock polymer through the cavities of α-CD units. For comparison, PPEOMA homopolymer was prepared and the inclusion complexation with α-CD was also studied. The ICs were prepared with a-CD when the polymer was in different conformations by changing the temperature, and the formed ICs were characterized by XRD, ^1H-NMR, TGA and DSC. The solutions of the ICs show temperature-responsive clear/turbid transition or fluidic emulsion/gel transition depending on the concentration of the α-CD added, and the stoichiometry determined by ^1H-NMR and TGA indicates that the stoichiometry of EO to α-CD of the resulted ICs increases with increasing of temperature.展开更多
Cardiovascular diseases(CVD)cause one third of all deaths in China,and the number is anticipated to double by 2020.They also greatly result in disability and adjusted life year loss.The prevalence of CVD has become a ...Cardiovascular diseases(CVD)cause one third of all deaths in China,and the number is anticipated to double by 2020.They also greatly result in disability and adjusted life year loss.The prevalence of CVD has become a new burden for China,due to an aging population,smoking,and changes in dietary habits and lifestyles.As the largest developing country,China needs to tailor her own national policies for managing CVD with full consideration of epidemiology,local needs,and afford-ability.Smoking cessation,increased physical activity,control of hypertension and hypercholesterolemia,and maintenance of a“traditional Chinese”diet should be important strategies for reducing the burden of CVD in China.Health officials in China should take their responsibilities to implement educational and preventive measures seriously.展开更多
基金financially supported by the Hunan Normal University for providing start-up
文摘The effect of temperature-responsive solution behavior of PNIPAM-b-PPEOMA-b-PNIPAM on its inclusion complexation with α-cyclodextrin was studied. The triblock polymer was prepared by reversible addition-fragmentation chain transfer （RAFT） polymerization and formed inclusion complexes （ICs） after selective threading of the PEO segment of the triblock polymer through the cavities of α-CD units. For comparison, PPEOMA homopolymer was prepared and the inclusion complexation with α-CD was also studied. The ICs were prepared with a-CD when the polymer was in different conformations by changing the temperature, and the formed ICs were characterized by XRD, ^1H-NMR, TGA and DSC. The solutions of the ICs show temperature-responsive clear/turbid transition or fluidic emulsion/gel transition depending on the concentration of the α-CD added, and the stoichiometry determined by ^1H-NMR and TGA indicates that the stoichiometry of EO to α-CD of the resulted ICs increases with increasing of temperature.
基金supported by the National Science Fund for Distinguished Young Scholars(No.30425016)the National Science Fund of China(Nos.30330290,30528011 and 30470961)+3 种基金the Special Funds for State Key Development Program for Basic Research of China(973 Program)(No.2007CB512100)the National High Technology Research and Development Program of China(863 Program)(No.2007AA02Z438)the Program Fund for Outstanding Medical Academic Leaders of Shanghai,Chinathe Program Fund for Shanghai Subject Chief Scientists,China,the Yangze Scholars Program Fund by the Ministry of Education,China,and the Program Fund for Innovative Research Teams by the Ministry of Education,China(all of the grants were to Dr Yi-Han CHEN).
文摘Cardiovascular diseases(CVD)cause one third of all deaths in China,and the number is anticipated to double by 2020.They also greatly result in disability and adjusted life year loss.The prevalence of CVD has become a new burden for China,due to an aging population,smoking,and changes in dietary habits and lifestyles.As the largest developing country,China needs to tailor her own national policies for managing CVD with full consideration of epidemiology,local needs,and afford-ability.Smoking cessation,increased physical activity,control of hypertension and hypercholesterolemia,and maintenance of a“traditional Chinese”diet should be important strategies for reducing the burden of CVD in China.Health officials in China should take their responsibilities to implement educational and preventive measures seriously.
