鄂尔多斯市6家医院糖尿病患者用药行为风险的知信行调查分析

目的调查鄂尔多斯市糖尿病患者用药行为风险的“知识-态度-行为”(KAP)模式现状,分析可能引起糖尿病患者用药行为风险的因素。方法采取非概率抽样法,于2021年1月至12月使用KAP问卷在线上和线下对鄂尔多斯市6家医院糖尿病患者进行问卷调查,采用多重线性回归分析用药行为风险KAP得分的影响因素。结果共回收有效问卷436份。受访对象用药知识、用药良好行为、用药不良行为、对用药教育态度和对教育频率满意度平均得分分别为(72.12±31.17)、(31.69±8.18)、(15.49±5.63)、(19.36±5.06)和(15.31±6.43)。多重线性回归分析结果显示,年龄、医保状况、居住地、受教育程度是用药知识的影响因素;年龄、性别是用药良好行为的影响因素;收入水平是用药不良行为的影响因素;年龄是对教育频率满意度的影响因素;年龄、医保状况是对用药教育态度的影响因素。结论通过本调查发现,鄂尔多斯市糖尿病患者对安全用药的认知情况、用药安全态度和安全的用药行为还有待提高,应根据患者的年龄、受教育程度、职业特点、医保情况以及居住地等有针对性地进行合理用药宣教。

Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch

Diterpenoid alkaloids have neroprotective activity.Herein,three napelline-type diterpenoid alkaloids 1-3,two aconitine-type diterpenoid alkaloids 4-5,and one isoquinline-type alkaloid 6,as well as one lignan glycoside 7,have been isolated from the roots of Aconitum pendulum Busch.Compounds 1 and 7 were new compounds,and their chemical structures were determined on the basis of nuclear magnetic resonance(NMR)spectra and mass spectrometry analysis.A ThT assay revealed that compound 2 showed significant disaggregation potency on the Aβ_(1−42)aggregates.

Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophila

This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s disease(AD)and the relationship between their anti-AD property and the geographic locations in China.Total extracts of all wolfberry samples showed the potent to decrease self-induced Aβ1-42 aggregation and Cu2+-induced Aβ1-42 aggregation and the antioxidant capacity as well as the bioactivity for binding biometal.A transgenic drosophila model assay revealed that TE of S1 and S6(S1-TE and S6-TE)at 100μg/mL demonstrated the potent rescue effect on memory loss compared to the positive control memantine at 20μg/mL.Further study also revealed the polysaccharide extracts could contribute to their anti-AD property,and the anti-AD activity conspicuously depends on growing environment.Wolfberry samples S1 and S6 showed much more potent anti-AD property.Meanwhile this study demonstrated that the Chinese commonly consumed wolfberry in boiling water might have the beneficial function to prevent AD pathology.

Phytochemicals and biological activities of Ligularia species

Ligularia,an important genus of the Compositae family,has captured the interest of natural product chemists for years.Phytochemical investigations on the title genus have led to isolation of hundreds of secondary metabolites with various skeletons.Herein,we summarized the chemical constituents of this genus and their biological activities over the past few decades.

Two New Eudesmane Sesquiterpenoids from the Flowers of Chrysanthemum indicum

The fowers of Chrysanthemum indicum,i.e.Ye-ju-hua recorded in the Chinese Pharmacopoeia,has been widely used in China as an important heat-clearing and detoxifying herb for the treatment of infammation,headache,and vertigo.A phytochemical investigation of this herb has led to the isolation of two new eudesmane sesquiterpenoids,7-epi-eudesm4(15),11(13)-diene-1β,3β-diol(1)and 7-epi-1β-hydroxy-β-eudesmol(2).The molecular structures of these new sesquiterpenoids were established based on the comprehensive spectroscopic analyses,including NMR,MS,and IR,and comparing with the literatures.

Sesquiterpenoids from the Rhizomes of Homalomena occulta

Naturally occurring oplopanane sesquiterpenoids are rarely reported.A phytochemical investigation on the rhizomes of Homalomena occulta(Lours)has resulted in the discovery of six oplopanane sesquiterpenoids(1–6),including four new(1–4)and one 3,5-seco-oplopanane(6),together with three previously reported sesquiterpenoids(7-9).In addition three new oplopananes(2a–4a)were also obtained by chemical transformation.All structures of these sesquiterpenoids were established based on the comprehensive spectroscopic analyses,including NMR,MS,and IR,and comparing with the literatures.

抗AD活性天然化合物的结构与功能

阿尔茨海默症(Alzheimer's disease, AD)已成为影响人类健康的第四大杀手,给全球公共健康带来重大影响与挑战.近年来,新型治疗AD药物的研制成为生命与健康领域的重要课题,如何发现具有抗AD活性的苗头分子和先导结构是其中的关键科学问题与技术难点.植物来源的天然化合物具有多骨架、多活性、多靶点的成药性特征.本文综述了AD的发病机制和具有抗AD活性的天然化合物的化学结构与功能,为新型抗AD药物的研制提供参考.