Influence of Collective Esophageal Speech Training on Self-efficacy in Chinese Laryngectomees:A Pretest-posttest Group Study

Total laryngectomy affects the speaking functions of many patients.Speech deprivation has great impacts on the quality of life of patients,especially on self-efficacy.Learning esophageal speech represents a way to help laryngectomees speak again.The purpose of this study was to determine the influence of collective esophageal speech training on self-efficacy of laryngectomees.In this study,28 patients and 30 family members were included.The participants received information about training via telephone or a WeChat group.Collective esophageal speech training was used to educate laryngectomees on esophageal speech.Before and after collective esophageal speech training,all participants completed the General Self-Efficacy Scale(GSES)to assess their perceptions on self-efficacy.Through the training,laryngectomees recovered their speech.After the training,the self-efficacy scores of laryngectomees were higher than those before the training,with significant differences noted(P<0.05).However,family members'scores did not change significantly.In conclusion,collective esophageal speech training is not only convenient and economical,but also improves self-efficacy and confidence of laryngectomees.Greater self-efficacy is helpful for laryngectomees to master esophageal speech and improve their quality of life.In addition,more attention should be focused on improving the self-efficacy of family members and making them give full play to their talent and potential on laryngectomees'voice rehabilitation.

Neurochemical features of endomorphin-2-containing neurons in the submucosal plexus of the rat colon

AIM:To investigate the distribution and neurochemical phenotype of endomorphin-2(EM-2)-containing neurons in the submucosal plexus of the rat colon.METHODS:The mid-colons between the right and left flexures were removed from rats,and transferred into Kreb's solution. For whole-mount preparations,the mucosal,outer longitudinal muscle and inner circularmuscle layers of the tissues were separated from the submucosal layer attached to the submucosal plexus. The whole-mount preparations from each rat mid-colon were mounted onto seven gelatin-coated glass slides,and processed for immunofluorescence histochemical double-staining of EM-2 with calcitonin gene-related peptide(CGRP),choline acetyltransferase(Ch AT),nitric oxide synthetase(NOS),neuron-specific enolase(NSE),substance P(SP) and vasoactive intestinal peptide(VIP). After staining,all the fluorescence-labeled sections were observed with a confocal laser scanning microscope. To estimate the extent of the co-localization of EM-2 with CGRP,Ch AT,NOS,NSE,SP and VIP,ganglia,which have a clear boundary and neuronal cell outline,were randomly selected from each specimen for this analysis. RESULTS:In the submucosal plexus of the mid-colon,many EM-2-immunoreactive(IR) and NSE-IR neuronal cell bodies were found in the submucosal plexus of the rat mid-colon. Approximately 6 ± 4.2 EM-2-IR neurons aggregated within each ganglion and a few EM-2-IR neurons were also found outside the ganglia. The EM-2-IR neurons were also immunopositive for Ch AT,SP,VIP or NOS. EM-2-IR nerve fibers coursed near Ch AT-IR neurons,and some of these fibers were even distributed around Ch AT-IR neuronal cell bodies. Some EM-2-IR neuronal cell bodies were surrounded by SP-IR nerve fibers,but many long processes connecting adjacent ganglia were negative for EM-2 immunostaining. Long VIP-IR processes with many branches coursed through the ganglia and surrounded the EM-2-IR neurons. The percentages of the EM-2-IR neurons that were also positive for Ch AT,SP,VIP or NOS were approximately 91% ± 2.6%,36% ± 2.4%,44% ± 2.5% and 44% ± 4.7%,respectively,but EM-2 did not co-localize with CGRP. CONCLUSION:EM-2-IR neurons are present in the submucosal plexus of the rat colon and express distinct neurochemical markers.

Differences in the effects of intravenous inhalational anesthesia and total intravenous anesthesia on the systemic traumatic response after laparoscopic cholecystectomy

Objective: To study the effect of intravenous inhalational anesthesia under monitoring on systemic traumatic response after laparoscopic cholecystectomy. Methods: A total of 80 cases of patients with chronic cholecystitis who received laparoscopic cholecystectomy in our hospital between June 2016 and October 2016 were collected and divided into the control group who accepted total intravenous anesthesia and the observation group who accepted intravenous inhalational anesthesia after the anesthesia methods were reviewed. 6 h, 12 h and 24 h after operation, the RIA method was adopted to determine the serum contents of pain mediators, enzyme-linked immunosorbent assay (ELISA) was used to determine serum levels of inflammatory factors and stress hormones, and auto-coagulation analyzer was used to detect the plasma contents of coagulation function indexes. Results: 6 h, 12 h and 24 h after operation, serum pain mediators 5-HT, β-EP and NPY levels of observation group were lower than those of control group, inflammatory factors hs-CRP, IL-6, IL-8 and TNF-α levels were lower than those of control group, and stress hormones Cor, ALD and NE levels were lower than those of control group;plasma coagulation function indexes TXB2, D-D and PLT levels of observation group were lower than those of control group. Conclusion: Intravenous inhalational anesthesia under monitoring can reduce the systemic traumatic reaction after laparoscopic cholecystectomy and has positive clinical significance.

Exponential Stability for Time-changed Stochastic Differential Equations

So far there have been few results presented on the exponential stability for time-changed stochastic differential equations.The main aim of this work is to fill this gap.By making use of general Lyapunov methods and time-changed Itôformula,we establish the exponential stability and almost sure exponential stability of solution to time-changed SDEs.Finally,we construct some examples to illustrate the effectiveness of our established theory.

On Variation of Single Birth Processes

Suppose {X（t）; t≥ 0} is a single birth process with birth rate qii＋l （i 〉 0） and death rate qij （i 〉 j ≥ 0）. It is proved in this paper that （i） if there exists aconstant c≥ 0 such that b（i）-a（i）＋ci is nondecreasing with respect to i and a（i） ＋ u（i） - ci ≥ 0 （i≥ 0）, then VarX（t）-EX（t）≥-X（0）e^-2ct,t≥0,or （ii） if there exists a constant u（i） - c≥ 0 such that b（i）-a（i）＋ci is non-increasing with respect to i and a（i）＋u（i）-ci≤0（i≥0）,then VarX（t） - EX（t） ≤ -X（0）e^-2c,t ≥ 0 Hereb（i） = qii＋1, a（0） = 0, a（i） = ∑j=^ijqii-j （i≥ 1）, u（0） = u（1） =0 and u（i） = 1/2∑j=^ij（j - 1）qii-j （i ≥ 2） . This result covers the results for birth-death processes obtained in [7].