Caveolin-1,E-cadherin and β-catenin in Gastric Carcinoma,Precancerous Tissues and Chronic Non-atrophic Gastritis

Objective： To investigate the expressions of caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous gastric and chronic non-atrophic gastritis tissues, and evaluate the correlation of these expressions with the development of gastric cancer. Methods： The expressions of caveolin-1, E-cadherin and β-catenin were detected by biotin-streptavidinperoxidase （SP） immunohistochemistry on 58 gastric cancer tissues, 40 precancerous gastric tissues and 42 chronic non-atrophic gastritis tissues. The correlation between the expressions of caveolin-1, E-cadherin and β-catenin, and the clinicopathologic parameters of gastric cancer was analyzed retrospectively. Results： The positive rates of caveolin-1 and E-cadherin expressions in gastric carcinoma were significantly lower than precancerous gastric and chronic non-atrophic gastritis tissues （P〈0.01）. An abnormal rate of β-catenin expression in gastric carcinoma was higher than precancerous gastric and chronic non-atrophic gastritis tissues （P〈0.01）. Moreover, low expressions of caveolin-1, E-cadherin and β-catenin correlated with tumor size, depth of invasion, lymph node metastasis and TNM stage （P〈0.05）. The positive rates of caveolin-1 and E-cadherin expressions decreased （P〈0.01）, while an abnormal rate of β-catenin expression increased inversely, with the degree of atypical hyperplasia （P〈0.01）. Caveolin-1 expression correlated positively with E-cadherin （r=0.41, P〈0.05）. Caveolin-1 （r=-0.36, P〈0.05） and E-cadherin （r=-0.45, P〈0.05） expressions negatively correlated with abnormal β-catenin expression. Conclusion： These results suggested that dysregulated expressions of caveolin-1, E-cadherin and β-catenin correlated with the development of gastric cancer and its biological behavior.

Alignment of beam position monitors in cryomodule of CADS injector Ⅱ

Significant temperature difference(300-77 K or even 4 K) can cause large deformations and displacements of the beam position monitors(BPMs),which affect BPMs measurement resolution or even cause their malfunction in cryogenic situations.In this paper,to check the offset from the mechanical to electrical center in low temperature(77 K),Fourier's law and finite element method are used to simulate cryo-deformation.Laser tracker and micro-alignment telescope are employed in combined BPM calibration,installation and monitoring.The calibration error is<0.02 mm,and the installation and monitoring precision are 0.06 mm and 0.01 mm,respectively.The monitored cryo-deformation agrees well with the simulation results.These indicate that the combined alignment can improve performance of the BPM system.All these guaranteed the success of running the 9.55 MeV@2.14 mA cw protons.

A noninvasive Ionization Profile Monitor for transverse beam cooling and orbit oscillation study in HIRFL-CSR

A noninvasive Ionization profile monitor(IPM)consisting of micro-channel plates,a phosphor screen and the optical-signal acquisition has been developed at the cooling storage ring of Heavy Ion Research Facility in Lanzhou(HIRFL-CSR).It makes the real-time profile measurements for the transverse beam cooling and orbit oscillation possible and efficient.This paper firstly describes all the IPM design criterions including the theoretical signal yield calculation,the space charge field and initial momentum evaluation,and the electrostatic field distortion simulation as well.In order to investigate the IPM performance,the beam profile measurements are done with different high voltage settings.Subsequently,some valuable beam experiments about the transverse electron cooling and orbit oscillation study are also presented.In the end,fast turn-by-turn profile measurements for the emittance blow-up research in a synchrotron are discussed.In cooperation with the newly deployed emittance instruments at the HIRFL-CSR injector,the IPM shows great prospects for the injection mismatch study,and potential values for the tune,dispersion and chromaticity measurements as well.

Design of fast adaptive readout system for wire scanners

A new wide-range fast readout system capable of adaptive identification is designed for wire scanners,which are used to measure beam profiles and emittance.This system is capable of handling varying current signals with Gaussian distributions and current pulses up to 1000 counts/s, as well as an input current range of 1 n A–1 m A. When tested, the resolution was found to exceed 3.68% for full scale, the nonlinearity was found to be less than 0.11%, and the measurement sensibility was found to be less than 5 p A. We believe that the system will play a crucial role in improving the measurement accuracy of beam diagnosis and the efficiency of accelerator operation,as well as decreasing the time required for beam tuning.This system was applied to the beam diagnosis of an injector II prototype for an accelerator-driven subcritical system and produced excellent measurement results. A description of the adaptive fast readout system for wire scanners is presented in this paper.

Investigation of factors affecting vertical sag of stretched wire

To study vertical sag requirements and factors affecting the stretched wire alignment method,the vertical sag equation is first derived theoretically.Subsequently,the influencing factors(such as the hanging weight or tension,span length,temperature change,elastic deformation,and the Earth’s rotation)of the vertical sag are summarized,and their validity is verified through actual measurements.Finally,the essential factors affecting vertical sag,i.e.,the specific strength and length,are discussed.It is believed that the vertical sag of a stretched wire is proportional to the square of the length and inversely proportional to the specific strength of the material.

Comparison of the closed analytical solution on the parameters of the alignment and surveying of the elements of accelerator under random errors

Purpose Compared with the iterative approximation solution,the analytically rigorous solution of the parameters of the accelerator alignment and surveying is the closed theoretical solution.To make the calculated error meet the negligible principle,in this paper,such examples of the zero,small angle and small translation,only large translation and no angle,only large angle without translation and large translation and large angle parameters under random errors are constructed.Methods Furthermore,Singular Value Decomposition,Eigen Value Decomposition,Polar Decomposition,Orthogonal Procrustes Analysis,and Successive Equivalent Differences Transformation are compared.Results In all the above examples,the mutual calculation deviation of Singular Value Decomposition,Eigen Value Decomposition,Polar Decomposition,and Orthogonal Procrustes analysis methods is less than 10 um.Its calculation accuracy is the highest,and Successive Equivalent Differences Transformation-3 has the largest calculation error,and Successive Equivalent Differences Transformation-N is in the middle.The results show that the coordinate residuals,parameters offsets and point position errors of the above solutions with random errors are all nearly zero.Conclusion It shows that the closed analytical solution is a rigorous solution.Moreover,it also shows that the constructed method of the coordinate point pairs is correct.