BACKGROUND Ganglioneuromas are rare tumors of the sympathetic nervous system that originate from neural crest sympathogonia.Since the cervical spine has rarely been reported as a site for ganglioneuroma,we present a c...BACKGROUND Ganglioneuromas are rare tumors of the sympathetic nervous system that originate from neural crest sympathogonia.Since the cervical spine has rarely been reported as a site for ganglioneuroma,we present a case report on this uncommon manifestation.CASE SUMMARY A 34-year-old male presented with a 4-month history of progressive paralysis of both upper limbs along with an unsteady gait.The touch sensitivity of both hands was reduced,and there was conspicuously high muscle tonus in his upper and lower limbs,along with hyperactive physiological reflection and deep reflexes.Magnetic resonance imaging showed several nodules around the C2-7 intervertebral foramena,among which the masses lying between C1 and C2 were obviously bilaterally compressing the spinal cord.Successful posterior decompression was performed without fixation and the tumors in the upper cervical spine were removed intact,with rapid relief of symptoms.The pathological diagnosis was ganglioneuroma.CONCLUSION Multiple and bilateral ganglioneuroams are a rare occurrence in the cervical spine.In this case report,timely resection of the neoplasms around C1 and C2 resulted in spinal cord decompression,with rapid relief of symptoms and a good prognosis.Including the current case,we are aware of only seven such cases in the literature,of which four arose from Japan,one from China,and one from Sp-ain.We suppose that ethnicity and geographic associations with this rare disease presentation may be an aspect for future consideration and investigation.展开更多
Reading guide 1778Repair of long-segment peripheral nerve defects1779Bionic reconstruction of hand function after adult brachial plexus root avulsion1780Optimized design of regeneration material for the treatment of p...Reading guide 1778Repair of long-segment peripheral nerve defects1779Bionic reconstruction of hand function after adult brachial plexus root avulsion1780Optimized design of regeneration material for the treatment of peripheral nerve injury1781Synergism of electroactive polymeric materials and electrical stimulation promotes peripheral nerve repair1783Schwann cell effect on peripheral nerve repair and regeneration .展开更多
文摘BACKGROUND Ganglioneuromas are rare tumors of the sympathetic nervous system that originate from neural crest sympathogonia.Since the cervical spine has rarely been reported as a site for ganglioneuroma,we present a case report on this uncommon manifestation.CASE SUMMARY A 34-year-old male presented with a 4-month history of progressive paralysis of both upper limbs along with an unsteady gait.The touch sensitivity of both hands was reduced,and there was conspicuously high muscle tonus in his upper and lower limbs,along with hyperactive physiological reflection and deep reflexes.Magnetic resonance imaging showed several nodules around the C2-7 intervertebral foramena,among which the masses lying between C1 and C2 were obviously bilaterally compressing the spinal cord.Successful posterior decompression was performed without fixation and the tumors in the upper cervical spine were removed intact,with rapid relief of symptoms.The pathological diagnosis was ganglioneuroma.CONCLUSION Multiple and bilateral ganglioneuroams are a rare occurrence in the cervical spine.In this case report,timely resection of the neoplasms around C1 and C2 resulted in spinal cord decompression,with rapid relief of symptoms and a good prognosis.Including the current case,we are aware of only seven such cases in the literature,of which four arose from Japan,one from China,and one from Sp-ain.We suppose that ethnicity and geographic associations with this rare disease presentation may be an aspect for future consideration and investigation.
基金supported by the National Natural Science Foundation of ChinaNo.31271055+37 种基金3147094420906088funded by the Chinese National Ministry of Science and Technology 973 ProjectNo.2014CB542201863 ProjectNo.SS2015AA020501the Ministry of Education Innovation Team(IRT1201)the National Natural Science FundNo.31571235313712103127128431171150the Educational Ministry New Century Excellent Talents Support ProjectNo.BMU20110270supported by the National Natural Science Foundation of ChinaNo.31200799 and 81571198the New Century Excellent Talents in UniversityNo.NCET-12-0742the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)supported by the Key Talent Fund Project of "Science Education for Health"Engineering of Health Department of Jiangsu Province of ChinaNo.RC2011101funded by Chinese National Ministry of Science and Technology 973 ProjectNo.2014CB542202Natural Science Foundation of ChinaNo.8137135481571182Natural Science Foundation of Guangdong ProvinceNo.S2013010014697Science and Technology Foundation of Guangdong ProvinceNo.2015A020212024funded by the National Natural Science Foundation of ChinaNo.3117094631300805the People’s Liberation Army 12th Five-Year Plan PeriodNo.BWS11J025the National Basic Research Program of ChinaNo.2012CB5181062014CB542201
文摘Reading guide 1778Repair of long-segment peripheral nerve defects1779Bionic reconstruction of hand function after adult brachial plexus root avulsion1780Optimized design of regeneration material for the treatment of peripheral nerve injury1781Synergism of electroactive polymeric materials and electrical stimulation promotes peripheral nerve repair1783Schwann cell effect on peripheral nerve repair and regeneration .
