Study of dual-directional regulatory effect of Banxia （Pinellia ternata） and Huanglian （Coptis chinensis） drug pair on gastrointestinal movement of mice

Objective： To evaluate the regulatory effects of Banxia （Pinellia ternata, P） and Huanglian （Coptis chinensis, C） drugpair, derived from Banxiaxiexin soup, on the gastrointestinal movement of mice with functional dyspepsia. Methods：Mice were treated with different proportions of the P and C drug pair （1：1, 3：1, and 4：1） for 10 days, and subsequentlyinjected with atropine （ATR） or neostigmine （NEO）. The effects of the different proportions of P and C were evaluatedbased on the alvine advance rate. In addition, we used the same modeling method used in the first experiment andadministered P： C at ratio of 3：1 and at different doses respectively （4.68 g/L, 2.34 g/L, and 1.17 g/L）, and tested levelsof the gastrointestinal hormones, gastrin （GAS）, vasoactive intestinal polypeptide （VIP）, and somatostatin （SS） in thesmall intestinal tissue using an enzyme-linked immunosorbent assay. Results： In the groups of NEO-induced mice, P：Cat ratios of 1：1, 3：1, and 4：1 significantly reduced the alvine advance rate compared with the NEO model group （P =0.003, P = 0.012 and P = 0.021, respectively）. In the groups of ATR-induced mice, only P：1 at ratio of 3：1 significantlyincreased the alvine advance rate compared with the ATR model group （P = 0.007）. After exposure to P： C at ratio of 3：1and at different dose, the GAS level was lower in the low-, medium-, and high-dose NEO groups than that in the NEOmodel group （P = 0.001, P = 0.004, and P = 0.003, respectively）. The VIP levels were higher in the medium-andhigh-dose NEO groups than that in the NEO model group （P = 0.004 and P = 0.002, respectively）. In addition, the SSlevel increased in the NEO medium-dose group compared with that in the NEO model group （P = 0.002）. The GAS levelwas higher in the ATR medium- and high-dose groups than in the ATR model group （P = 0.007 and P = 0.021,respectively）. The VIP level was lower in the ATR low-, medium-, and high-dose than that in the ATR model group （P =0.001, P = 0.001, and P = 0.001, respectively）. Furthermore, the SS level was lower in the ATR medium- and high-dosegroups than that in the ATR model group （P = 0.001 and P = 0.006）. Conclusion： The PC drug pair bidirectionallyadjusted the NEO- and ATR-induced functional dyspepsia in mice by modulating GAS, VIP, and SS levels in theintestine.

Effect of microstructure variation on corrosion properties of as-cast 0Cr23Ni13 stainless steel at high strain rate of hot compression

The optimization of hot compression technique of as-cast 0Cr23Ni13 stainless steel at high strain rate was discussed,and its corrosion resistance was evaluated after hot compression treatment experimentally.By adjusting the dynamic recrys-tallization(DRX)ratio of 0Cr23Nil3 stainless steel during hot pressing,the content of low Σ coincident site lattice(ΣCSL)grain boundaries is increased,and the grain orientation is optimized.The results show that ferrite and austenite are completely recrystallized at 1050 and 1150℃,respectively.The number of grains in the<111>and<101>directions increases significantly,the corrosion potential increases,and the corrosion current density decreases,which will signifi-cantly improve the corrosion resistance of 0Cr23Nil3 stainless steel.After the optimization of grain boundary distribution,corrosion resistance is noticeably improved due to the existence of lowΣCSL boundaries.The interference effect of lowΣCSL grain boundary on random grain boundary network becomes intense with the increase in DRX ratio,which is the fundamental measure to improve the corrosion resistance.