Pharmacokinetics of Gelsemium elegans in female rats

Background:Gelsemium elegans Benth(G.elegans)is a poisonous perennial evergreen vine plant that has been applied in livestock production and veterinary clinical practice.Early studies found that the toxicity of G.elegans showed significant gender differences in rats,but the underlying reasons for this difference are still not well understood.Methods:In order to explore whether the gender differences in the toxicity of G.elegans are related to pharmacokinetic differences,based on the previous pharmacokinetic study of multiple components of G.elegans in male rats,this study used HPLC-MS/MS method established in the laboratory to conduct a pharmacokinetic study of multiple alkaloids in the plasma of female rats after a single gavage administration of G.elegans(dose of 0.1 g/kg).Results:Through detection,17 alkaloid components in the plasma of female rats were identified,and the pharmacokinetic parameters of 11 of these alkaloids were calculated.We find that in female rats.The T_(max)values were generally less than 0.5 h,and the T_(1/2)values exceeded 3 h,with the longest reaching up to 32.80 h half elimination time.Additionally,the C_(max)and AUC results indicated that female rats had generally higher absorption and exposure levels for most alkaloids.Conclusion:These results suggest that the reason for the differences in the toxicology of G.elegans may be related to the absorption and exposure of gelsemidine-type alkaloids in animals.

Hematopoiesis reconstitution and anti-tumor effectiveness of Pai-Neng-Da capsule in acute leukemia patients with haploidentical hematopoietic stem cell transplantation

BACKGROUND With the rapid development of haploidentical hematopoietic stem cell transplantation(haplo-HSCT),primary poor graft function(PGF)has become a lifethreatening complication.Effective therapies for PGF are inconclusive.New Chinese patent medicine Pai-Neng-Da(PND)Capsule exerts dual effect in promoting hematopoiesis recovery and regulating immunity.Still,the application of PND capsule in hematopoietic stem cell transplantation,especially in the haplo-HSCT setting,has not yet been reported.AIM To evaluate the role of PND capsule in acute leukemia patients with haplo-HSCT.METHODS We retrospectively collected data of acute leukemia patients who underwent haplo-HSCT at the Affiliated People’s Hospital of Ningbo University between April 1,2015 and June 30,2020.Twenty-nine consecutive patients received oral PND capsule from the sixth day to the first month after haplo-HSCT were included in the PND group.In addition,31 patients who did not receive PND capsule during haplo-HSCT were included in the non-PND group.Subsequently,we compared the therapeutic efficacy according to the western medical evaluation indexes and Chinese medical symptom scores,and the survival between the PND group and the non-PND group,using the chi-square test,Fisher’s exact test,and the Kaplan-Meier method.RESULTS The duration of platelet engraftment was shorter in the PND group than in the non-PND group(P=0.039).The PND group received a lower frequency of red blood cells and platelet transfusions than the non-PND group(P=0.033 and P=0.035,respectively).In addition,PND capsule marginally reduced the rate of PGF(P=0.027)and relapse(P=0.043).After 33(range,4-106)months of follow-up,the 3-year relapse-free survival(P=0.046)and progression-free survival(P=0.049)were improved in the PND group than in the non-PND group.Also,the therapeutic efficacy of the PND group according to Chinese medical symptom scores was significantly better than that of the non-PND group(P=0.022).Moreover,the adverse events caused by PND capsule were mild.Nevertheless,there were no significant differences in the duration of neutrophil engraftment,the risk of infection within 100 days after haplo-HSCT,the acute graft-versus-host disease,or the 3-year overall survival between the two groups.CONCLUSION PND capsule could promote hematopoiesis reconstitution,improve the therapeutic efficacy of Chinese medical symptom scores,present anti-tumor effectiveness,and prolong the survival of acute leukemia patients with haplo-HSCT.

Benefits of orchidopexy on the fertility of adult men Nith bilateral cryptorchidism

Dear Editor, The incidence of cryptorchidism is approximately 0.8% at 1 year of age and remains at this level throughout adulthood. One-third of these patients have bilaterally cryptorchid testes.1 Most patients with cryptorchidism have this condition corrected by surgery before puberty. Therefore, adult bilateral cryptorchidism （BC） is not observed frequently in clinical practice. Bilateral undescended testes are commonly associated with azoospermia and male infertility. Orchiopexy is usually considered a cosmetic operation and to reduce cancer risk when performed in adult men, and is generally thought to have no effect on spermatogenic recovery. We conducted a single-center retrospective study to evaluate the efficacy of orchidopexy and its effect on fertility in adult men with BC.

Feature detection of triangular meshes via neighbor supporting

We propose a robust method for detecting features on triangular meshes by combining normal tensor voting with neighbor supporting. Our method contains two stages： feature detection and feature refinement. Firsts the normal tensor voting method is modified to detect the initial features, which may include some pseudo features. Then, at the feature refinement stage, a novel salient measure deriving from the idea of neighbor supporting is developed. Benefiting from the integrated reliable salient measure feature, pseudo features can be effectively discriminated from the initially detected features and removed. Compared to previous methods based on the differential geometric property, the main advantage of our method is that it can detect both sharp and weak features. Numerical experiments show that our algorithm is robust, effective, and can produce more accurate results. We also discuss how detected features are incorporated into applications, such as feature-preserving mesh denoising and hole-filling, and present visually appealing results by integrating feature information.

Smelting recrystallization of CsPbBrI_(2)perovskites for indoor and outdoor photovoltaics

A smelting multiple recrystallization strategy and its effects on the morphology,composition,and defects of CsPbBrI_(2)film were investigated.An optimal number(n=2)of recrystallization cycles improved the crystallinity and phase purity,minimized the grain boundaries,and optimized the crystal structure,yielding a high-quality perovskite film with significantly reduced defects density.The corresponding photovoltaic devices exhibited a champion efficiency of 16.02%under AM 1.5 G illumination and presented an even higher indoor efficiency of 33.50%under an LED(2956 K,P_(in):334.41𝜇W/cm^(2)).This recrystallization method offers a promising strategy for developing high-performance indoor and outdoor photovoltaics.Direct recrystallization in the cells was also explored to achieve enhanced stability and longer lifetime in humid conditions.

High-order numerical method for the derivative nonlinear Schrodinger equation

In this work,a fourth-order numerical scheme in space and two second-order numerical schemes in both time and space are proposed for the derivative nonlinear Schrodinger equation.We verify the mass conservation for the two-level implicit scheme.The influence on the soliton solution by adding a small random perturbation to the initial condition is discussed.The numerical experiments are given to test the accuracy order for different schemes,respectively.We also test the conservative property of mass and Hamiltonian for these schemes from the numerical point of view.

A code-based approach for labeling in complex irregular regions

Labeling information in a complex irregular region is a useful procedure occurring frequently in sheet metal and the furniture industry which will be beneficial in parts management.A fast code-based labeler(FCBL) is proposed to accomplish this objective in this paper.The region is first discretized,and then encoded by the Freeman encoding technique for providing the 2D regional information by 1D codes with redundancies omitted.We enhance the encoding scheme to make it more suitable for our complex problem.Based on the codes,searching algorithms are designed and can be extended with customized constraints.In addition,by introducing a smart optimal direction estimation,the labeling speed and accuracy of FCBL are significantly improved.Experiments with a large range of real data gained from industrial factories demonstrate the stability and millisecond-level speed of FCBL.The proposed method has been integrated into a shipbuilding CAD system,and plays a very important role in ship parts labeling process.