We investigated phase transitions in a diblock copolymer–homopolymer hybrid system blended with nanorods(NRs)by using the time-dependent Ginzburg–Landau theory.We systematically studied the effects of the number,len...We investigated phase transitions in a diblock copolymer–homopolymer hybrid system blended with nanorods(NRs)by using the time-dependent Ginzburg–Landau theory.We systematically studied the effects of the number,length and infiltration properties of the NRs on the self-assembly of the composites and the phase transitions occurring in the material.An analysis of the phase diagram was carried out to obtain the formation conditions of sea island structure nanorodbased aggregate,sea island structure nanorod-based dispersion,lamellar structure nanorod-based multilayer arrangement and nanowire structure.Further analysis of the evolution of the domain sizes and the distribution of the nanorod angle microphase structure was performed.Our simulation provides theoretical guidance for the preparation of ordered nanowire structures and a reference to improve the function of a polymer nanocomposite material.展开更多
With the emergence and rapid development of nanotechnology,the nanoparticles hybridized with multicomponent lipids are more and more used in gene delivery.These vectors interact with the cell membrane before entering ...With the emergence and rapid development of nanotechnology,the nanoparticles hybridized with multicomponent lipids are more and more used in gene delivery.These vectors interact with the cell membrane before entering into the cell.Therefore,the nature of this interaction is important in investigating multicomponent liposome-nanoparticle(MLP)transport across the cell membrane.In this paper the transport of MLPs across the membranes of giant vesicles(GVs)in solvents is studied by using the self-consistent field theory(SCFT).Based on the analysis of the MLP permeating the GV membranes,a simple transport model is proposed.The effects of the difference in membrane morphology and the size of the nanoparticle on the endocytosis are discussed systematically.The role of energy barriers in quasi-equilibrium is also examined.The results indicate that the interaction between MLP and GV is a spontaneous process and the energy barrier needs overcoming to form metastable intermediates.The results provide theoretical reference for better understanding the transmembrane transport process of nanoparticles,and guidance for relevant experimental studies as well.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant No.21373131)the Provincial Natural Science Foundation of Shanxi,China(Grant No.2015011004)the Research Foundation for Excellent Talents of Shanxi Provincial Department of Human Resources and Social Security,China
文摘We investigated phase transitions in a diblock copolymer–homopolymer hybrid system blended with nanorods(NRs)by using the time-dependent Ginzburg–Landau theory.We systematically studied the effects of the number,length and infiltration properties of the NRs on the self-assembly of the composites and the phase transitions occurring in the material.An analysis of the phase diagram was carried out to obtain the formation conditions of sea island structure nanorodbased aggregate,sea island structure nanorod-based dispersion,lamellar structure nanorod-based multilayer arrangement and nanowire structure.Further analysis of the evolution of the domain sizes and the distribution of the nanorod angle microphase structure was performed.Our simulation provides theoretical guidance for the preparation of ordered nanowire structures and a reference to improve the function of a polymer nanocomposite material.
基金Project supported by the Science and Technology Innovation Project of Higher Education in Shanxi Province,China(Grant No.2020L0752)the Basic Research Foundation Project in Modern College of Humanities and Sciences of Shanxi Normal University,China(Grant No.2020JCYJ25)the Graduate Student Science and Technology Innovation Project of Shanxi Normal University,China(Grant No.01053011)。
文摘With the emergence and rapid development of nanotechnology,the nanoparticles hybridized with multicomponent lipids are more and more used in gene delivery.These vectors interact with the cell membrane before entering into the cell.Therefore,the nature of this interaction is important in investigating multicomponent liposome-nanoparticle(MLP)transport across the cell membrane.In this paper the transport of MLPs across the membranes of giant vesicles(GVs)in solvents is studied by using the self-consistent field theory(SCFT).Based on the analysis of the MLP permeating the GV membranes,a simple transport model is proposed.The effects of the difference in membrane morphology and the size of the nanoparticle on the endocytosis are discussed systematically.The role of energy barriers in quasi-equilibrium is also examined.The results indicate that the interaction between MLP and GV is a spontaneous process and the energy barrier needs overcoming to form metastable intermediates.The results provide theoretical reference for better understanding the transmembrane transport process of nanoparticles,and guidance for relevant experimental studies as well.
