Evaluation of the tumor load and adverse reactions of nedaplatin combined with paclitaxel liposome and with paclitaxel treatment of advanced esophageal cancer

Objective:To evaluate the tumor load and adverse reactions of nedaplatin combined with paclitaxel liposome and with paclitaxel treatment of advanced esophageal cancer.Methods:A total of 68 patients with advanced esophageal cancer who were treated in our hospital between August 2013 and March 2016 were collected and divided into the paclitaxel liposome group (n=34) who received nedaplatin combined with paclitaxel liposome therapy and the paclitaxel group (n=34) who received nedaplatin combined with paclitaxel therapy according to the double-blind randomized control method, and both therapies lasted for 8 weeks. Before treatment and after 8 weeks of treatment, RIA method was used to determine serum esophageal cancer-related tumor marker levels, enzyme-linked immunosorbent assay was used to determine serum angiogenesis index levels, and flow cytometry was used to measure cellular immunity indexes.Results: Before treatment, the differences in serum tumor marker and angiogenesis index levels as well as cellular immune function indexes were not statistically significant between the two groups. After 8 weeks of treatment, serum tumor markers CY211, CEA, SCC, CA724 and CA125 levels of observation group were lower than those of control group, angiogenesis indexes HIF-α, VEGF and MMP-9 levels were lower than those of control group, and peripheral blood cellular immunity indexes CD4+ and CD4+/CD8+ levels were higher than those of control group while CD8+ level was lower than that of control group. Conclusion: Nedaplatin combined with paclitaxel liposome can more effectively reduce the tumor load, causes less adverse effects, and has good curative effect and security.

New Constructions of Orbit Codes Based on the Operations of Orbit Codes

An orbit code is a special constant dimension subspace code,which is an orbit of a subgroup of a general linear group acting on the set of all subspaces in the given ambient space.This paper presents some methods of constructing new orbit codes from known orbit codes.Firstly,we introduce the sum operation,intersection operation and union operation of subspace codes,and then we give some methods to obtain new orbit codes from known orbit codes by fully applying the sub-orbits of permutation groups and the direct product operation of the groups.Finally,as a special application,partial spread codes are researched and a condition of orbit codes with constant distance is given.