As an emerging type of adult stem cell featuring non-invasive acquisition,urine-derived stem cells(USCs)have shown great potential for applications in tissue engineering and regenerative medicine.With a growing amount...As an emerging type of adult stem cell featuring non-invasive acquisition,urine-derived stem cells(USCs)have shown great potential for applications in tissue engineering and regenerative medicine.With a growing amount of research on the topic,the effectiveness of USCs in various disease models has been shown and the underlying mechanisms have also been explored,though many aspects still remain unclear.In this review,we aim to provide an up-to-date overview of the biological characteristics of USCs and their applications in skin,bone and articular cartilage repair.In addition to the identification procedure of USCs,we also summarize current knowledge of the underlying repair mechanisms and application modes of USCs.Potential concerns and perspectives have also been summarized.展开更多
基金supported by National Natural Science Foundation of China(Grant No.31771065)the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Grant No.ZYJC18002).
文摘As an emerging type of adult stem cell featuring non-invasive acquisition,urine-derived stem cells(USCs)have shown great potential for applications in tissue engineering and regenerative medicine.With a growing amount of research on the topic,the effectiveness of USCs in various disease models has been shown and the underlying mechanisms have also been explored,though many aspects still remain unclear.In this review,we aim to provide an up-to-date overview of the biological characteristics of USCs and their applications in skin,bone and articular cartilage repair.In addition to the identification procedure of USCs,we also summarize current knowledge of the underlying repair mechanisms and application modes of USCs.Potential concerns and perspectives have also been summarized.
