Ovarian cancer is a common cancer for females,and the incidence and mortality rates are on the rise.Many treatment strategies have been developed for ovarian cancer,including chemotherapy and immunotherapy,but they ar...Ovarian cancer is a common cancer for females,and the incidence and mortality rates are on the rise.Many treatment strategies have been developed for ovarian cancer,including chemotherapy and immunotherapy,but they are often ineffective and prone to drug resistance.Protein ubiquitination is an important class of post-translation modifications that have been found to be associated with various human diseases and cancer development.Recent studies have revealed that protein ubiquitination is involved in the progression of ovarian cancer and plays an important role in the tumor immune process.Moreover,the com-bination of ubiquitinase/deubiquitinase inhibitors and cancer immunotherapy approaches can effectively reduce treatment resistance and improve treatment efficacy,which provides new ideas for cancer treatment.Herein,we review the role of protein ubiquitination in relation to ovarian cancer immunotherapy and recent advances in the use of ubiquitinase/deubiquitinase inhibitorsin combil ationwitncaner mmunotherapy.展开更多
基金supported by the National Natural Science Foundation of China (No.82002751)the Medical Science and Technology Project of HenanProvince,China (No.SBGJ202102139)+3 种基金China Postdoctoral Science Foundation (No.2020M682361)Excellent Youth Foundation of Henan Province,China (No.222300420071)Outstanding Young Talents of Health Science and Technology Innovation of Henan Province,China (No.YXKC2022033)the Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University,Henan,China (No.QNCXTD2023005).
文摘Ovarian cancer is a common cancer for females,and the incidence and mortality rates are on the rise.Many treatment strategies have been developed for ovarian cancer,including chemotherapy and immunotherapy,but they are often ineffective and prone to drug resistance.Protein ubiquitination is an important class of post-translation modifications that have been found to be associated with various human diseases and cancer development.Recent studies have revealed that protein ubiquitination is involved in the progression of ovarian cancer and plays an important role in the tumor immune process.Moreover,the com-bination of ubiquitinase/deubiquitinase inhibitors and cancer immunotherapy approaches can effectively reduce treatment resistance and improve treatment efficacy,which provides new ideas for cancer treatment.Herein,we review the role of protein ubiquitination in relation to ovarian cancer immunotherapy and recent advances in the use of ubiquitinase/deubiquitinase inhibitorsin combil ationwitncaner mmunotherapy.
